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CBX6 [nucleoplasm]
Stable Identifier
R-HSA-3229071
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Chromobox protein homolog 6
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Demethylation of H3K27Me3 by KDM6B stimulates p16INK4A transcription, while binding of PRC1.4 complex to H3K27Me3 represses p16INK4A transcription (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX6 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX6 [nucleoplasm] (Homo sapiens)
PRC1.4 complex binds H3K27Me3 nucleosomes on CDKN2A promoter (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX6 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX6 [nucleoplasm] (Homo sapiens)
p-MAPKAPK3 phosphorylates BMI1 (Homo sapiens)
CDKN2A Gene:H3K27Me3-Nucleosome:PRC1.4 [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX6 [nucleoplasm] (Homo sapiens)
p-PRC1.4 complex [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX6 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
RUNX1 binds PRC1 complexes (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX6 [nucleoplasm] (Homo sapiens)
RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX6 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
PIP3 activates AKT signaling (Homo sapiens)
PTEN Regulation (Homo sapiens)
Regulation of PTEN gene transcription (Homo sapiens)
MECOM (EVI1) recruits polycomb repressor complexes (PRCs) to the PTEN gene promoter (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX6 [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX6 [nucleoplasm] (Homo sapiens)
PTEN gene transcription is stimulated by TP53, EGR1, PPARG, ATF2, MAF1, and inhibited by NR2E1, SALL4, MECOM, SNAI1, SNAI2, JUN (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX6 [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core):PTEN gene [nucleoplasm] (Homo sapiens)
MECOM:(PRC1.4,PRC2 (EZH2) core) [nucleoplasm] (Homo sapiens)
PRC1.4,PRC2 (EZH2) core [nucleoplasm] (Homo sapiens)
PRC1.4 [nucleoplasm] (Homo sapiens)
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
CBX6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95503 CBX6
Gene Names
CBX6
Chain
chain:1-412
Reference Genes
BioGPS Gene:23466 CBX6
COSMIC (genes):CBX6 CBX6
CTD Gene:23466 CBX6
dbSNP Gene:23466 CBX6
ENSEMBL:ENSG00000183741 CBX6
HGNC:1556 CBX6
KEGG:hsa:23466 CBX6
Monarch:23466 CBX6
NCBI Gene:23466 CBX6
OMIM:617438 CBX6
UCSC:O95503 CBX6
Reference Transcript
RefSeq:NM_014292.4 CBX6
RefSeq:NM_001303494.1 CBX6
Other Identifiers
11720081_a_at
11720082_at
16935195
202047_PM_s_at
202047_s_at
202048_PM_s_at
202048_s_at
23466
39561_at
3960931
3960932
3960933
3960934
3960935
3960936
3960937
3960938
3960939
3960940
3960941
3960942
3960943
3960944
3960945
3960946
3960947
3960948
3960949
3960950
3960951
3960952
3960953
8076176
A_24_P254437
A_24_P370372
A_33_P3270485
GE81906
GO:0000122
GO:0000785
GO:0000792
GO:0003682
GO:0003723
GO:0003727
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006325
GO:0006355
GO:0016604
GO:0031519
GO:0035064
GO:0035102
GO:0042393
GO:0043226
HMNXSV003005540
HMNXSV003022144
HMNXSV003051214
Hs.107374.0.A1_3p_a_at
ILMN_1691930
PH_hs_0026686
TC22000799.hg
g10140848_3p_a_at
Participates
as a member of
CBX2,CBX4,CBX6,CBX8 [nucleoplasm] (Homo sapiens)
Inferred To
Cbx6 [nucleoplasm]
(Mus musculus)
Cbx6 [nucleoplasm]
(Rattus norvegicus)
Pc [nucleoplasm]
(Drosophila melanogaster)
CBX6 [nucleoplasm]
(Bos taurus)
CBX6 [nucleoplasm]
(Canis familiaris)
CBX6 [nucleoplasm]
(Gallus gallus)
CBX6 [nucleoplasm]
(Sus scrofa)
cbx6 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001290423.1
,
NP_055107.3
ENSEMBL
ENSP00000384490
,
ENST00000407418
OpenTargets
ENSG00000183741
HPA
ENSG00000183741-CBX6
PRO
O95503
Pharos - Targets
O95503
PDB
3GV6
,
3I90
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35227 PCGF2
1
PCGF2 [nucleoplasm]
(R-HSA-389115)
0.759
5
UniProt:O00425 IGF2BP3
1
IGF2BP3 [cytosol]
(R-HSA-428313)
0.527
2
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.527
2
UniProt:Q9Y4W2 LAS1L
1
LAS1L [nucleoplasm]
(R-HSA-6791521)
0.527
2
UniProt:Q9Y6M1 IGF2BP2
1
IGF2BP2 [cytosol]
(R-HSA-428302)
0.527
2
UniProt:P11940 PABPC1
1
PABPC1 [cytosol]
(R-HSA-156803)
0.527
2
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