MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription

Stable Identifier
R-HSA-3229138
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
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MAPKAPK2/3-mediated removal of PRC1.4 complex stimulates p14ARF transcription
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Transcription of p14ARF in response to oxidative stress induced p38 signaling is positively regulated by MAPKAPK3-mediated phosphorylation of BMI1 and the subsequent dissociation of the PRC1.4 complex from the CDKN2A locus (Voncken et al. 2005).

Literature References
PubMed ID Title Journal Year
15563468 MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1

Voncken, JW, Niessen, H, Neufeld, B, Rennefahrt, U, Dahlmans, V, Kubben, N, Holzer, B, Ludwig, S, Rapp, UR

J. Biol. Chem. 2005
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Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-26)