SUMOylation of transcription factors

Stable Identifier
R-HSA-3232118
Type
Pathway
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Proteins classified as transcription factors constitute a disproportionate number of SUMOylation targets. In most cases SUMOylation inhibits transcriptional activation, however in some cases such as TP53 (p53) SUMOylation can enhance activation. Inhibition of transcription by SUMOylation may be due to interference with DNA binding, re-localization to inactive nuclear bodies, or recruitment of repressive cofactors such as histone deacetylases (reviewed in Girdwood et al. 2004, Gill 2005).

Literature References
PubMed ID Title Journal Year
16095902 Something about SUMO inhibits transcription

Gill, G

Curr. Opin. Genet. Dev. 2005
18031228 A role for SUMO modification in transcriptional repression and activation

Lyst, MJ, Stancheva, I

Biochem. Soc. Trans. 2007
19616654 SUMO association with repressor complexes, emerging routes for transcriptional control

Garcia-Dominguez, M, Reyes, JC

Biochim. Biophys. Acta 2009
19107415 Regulation of transcription factor activity by SUMO modification

Ouyang, J, Valin, A, Gill, G

Methods Mol. Biol. 2009
21892772 Emerging roles of the SUMO pathway in development

Lomelí, H, Vázquez, M

Cell. Mol. Life Sci. 2011
15209380 SUMO and transcriptional regulation

Girdwood, DW, Tatham, MH, Hay, RT

Semin. Cell Dev. Biol. 2004
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