Reactome | SUMOylation of transcription factors

SUMOylation of transcription factors

Stable Identifier

R-HSA-3232118

DOI

10.3180/R-HSA-3232118.6

Type

Pathway

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Proteins classified as transcription factors constitute a disproportionate number of SUMOylation targets. In most cases SUMOylation inhibits transcriptional activation, however in some cases such as TP53 (p53) SUMOylation can enhance activation. Inhibition of transcription by SUMOylation may be due to interference with DNA binding, re-localization to inactive nuclear bodies, or recruitment of repressive cofactors such as histone deacetylases (reviewed in Girdwood et al. 2004, Gill 2005).

Literature References

PubMed ID	Title	Journal	Year
18031228	A role for SUMO modification in transcriptional repression and activation Lyst, MJ, Stancheva, I	Biochem. Soc. Trans.	2007
16095902	Something about SUMO inhibits transcription Gill, G	Curr. Opin. Genet. Dev.	2005
19616654	SUMO association with repressor complexes, emerging routes for transcriptional control Garcia-Dominguez, M, Reyes, JC	Biochim. Biophys. Acta	2009
19107415	Regulation of transcription factor activity by SUMO modification Ouyang, J, Valin, A, Gill, G	Methods Mol. Biol.	2009
21892772	Emerging roles of the SUMO pathway in development Lomelí, H, Vázquez, M	Cell. Mol. Life Sci.	2011
15209380	SUMO and transcriptional regulation Girdwood, DW, Tatham, MH, Hay, RT	Semin. Cell Dev. Biol.	2004