SUMOylation of TFAP2C with SUMO1

Stable Identifier
R-HSA-3234094
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SUMOylation of TFAP2C with SUMO1
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UBE2I (UBC9) interacts with the C-terminal region of TFAP2C (Eloranta and Hurst 2002). SUMOylation of TFAP2C occurs at lysine-10 and causes a reduction in its transcriptional activation activity. A dominant negative mutant of UBC9 led to increased activity of TFAP2C therefore UBC9 is assumed to catalyze the ligation of SUMO1 to TFAP2C.
Literature References
PubMed ID Title Journal Year
12072434 Transcription factor AP-2 interacts with the SUMO-conjugating enzyme UBC9 and is sumolated in vivo

Eloranta, JJ, Hurst, HC

J. Biol. Chem. 2002
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Catalyst Activity

SUMO transferase activity of SUMO1:C93-UBE2I [nucleoplasm]

Physical Entity
SUMO1:C93-UBE2I [nucleoplasm] (Homo sapiens)
Activity
SUMO transferase activity (GO:0019789)
Orthologous Events
SUMOylation of TFAP2A with SUMO1 (Homo sapiens)
SUMOylation of TFAP2B with SUMO1 (Homo sapiens)
SUMOylation of TFAP2C with SUMO1 (Bos taurus)
SUMOylation of TFAP2C with SUMO1 (Caenorhabditis elegans)
SUMOylation of TFAP2C with SUMO1 (Danio rerio)
SUMOylation of TFAP2C with SUMO1 (Gallus gallus)
SUMOylation of TFAP2C with SUMO1 (Mus musculus)
SUMOylation of TFAP2C with SUMO1 (Rattus norvegicus)
SUMOylation of TFAP2C with SUMO1 (Sus scrofa)
SUMOylation of TFAP2C with SUMO1 (Xenopus tropicalis)
Authored
May, B  (2013-03-27)
Reviewed
Zarelli, VE  (2016-05-04)
Bogachek, MV  (2016-05-17)
Dawid, IB  (2016-05-04)
Weigel, RJ  (2016-05-17)
Created
May, B  (2013-03-27)
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