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p-T182-MAPKAPK5 [nucleoplasm]
Stable Identifier
R-HSA-3239018
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-T182-PRAK
Icon
Locations in the PathwayBrowser for interactor UniProt:Q15109 AGER
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK6/MAPK4 signaling (Homo sapiens)
p-T182 MAPKAPK5 phosphorylates FOXO1 (Homo sapiens)
p-T182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IW41 MAPKAPK5
Gene Names
MAPKAPK5, PRAK
Chain
chain:1-473
Reference Genes
BioGPS Gene:8550 MAPKAPK5
COSMIC (genes):MAPKAPK5 MAPKAPK5
CTD Gene:8550 MAPKAPK5
dbSNP Gene:8550 MAPKAPK5
ENSEMBL:ENSG00000089022 MAPKAPK5
ENSEMBL_homo_sapiens_GENE:ENSG00000089022.15 MAPKAPK5
HGNC:6889 MAPKAPK5
KEGG Gene (Homo sapiens):8550 MAPKAPK5
Monarch:8550 MAPKAPK5
NCBI Gene:8550 MAPKAPK5
OMIM:606723 MAPKAPK5
UCSC:Q8IW41 MAPKAPK5
Reference Transcript
RefSeq:NM_003668.3 MAPKAPK5
RefSeq:NM_139078.2 MAPKAPK5
Other Identifiers
11723970_at
16757181
16757209
212871_PM_at
212871_at
228925_PM_at
228925_at
3432139
3432140
3432145
3432146
3432147
3432148
3432149
3432150
3432151
3432153
3432156
3432157
3432160
3432161
3432163
3432167
3432168
3432169
3432170
3432171
3432172
3432173
3432174
3432175
3432176
3432179
3432180
3432181
3432182
3432183
3432184
3432185
3432186
3432187
3432188
3432189
3432204
3432206
3432208
3432210
3432212
3432214
41506_at
7958800
8550
86882_at
A_14_P113146
A_14_P200357
A_21_P0000668
A_23_P87810
A_24_P124662
GE54249
GE716401
GE831332
GE87779
GO:0000165
GO:0000166
GO:0002039
GO:0003824
GO:0004672
GO:0004674
GO:0004683
GO:0004708
GO:0005515
GO:0005516
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0006417
GO:0006468
GO:0007165
GO:0007265
GO:0009931
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0032007
GO:0032156
GO:0032200
GO:0032212
GO:0032991
GO:0035556
GO:0036211
GO:0043226
GO:0046777
GO:0048856
GO:0051019
GO:0051973
GO:0060999
GO:0090398
GO:0090400
GO:0106310
GO:0140096
GO:1901796
GO:1904355
HMNXSV003030200
HMNXSV003038961
Hs.207422.0.A1_3p_at
Hs.30327.0.S1_3p_at
ILMN_1699082
ILMN_2322935
PH_hs_0024960
TC12000872.hg
TC12000873.hg
TC12002570.hg
p34641
p3853
Participates
as a component of
p-S MAPK6,4:p-T182 MAKPAPK5 [nucleoplasm] (Homo sapiens)
phospho-p38 MAPK:p-T-182-MAPKAPK5 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-T182 MAPKAPK5 [cytosol]
p-S115 MAPKAPK5 [cytosol]
p-S115 MAPKAPK5 [nucleoplasm]
MAPKAPK5 [nucleoplasm]
Inferred To
phospho-p-T182-MAPKAPK5 [nucleoplasm]
(Gallus gallus)
phospho-p-T182-MAPKAPK5 [nucleoplasm]
(Mus musculus)
phospho-p-T182-MAPKAPK5 [nucleoplasm]
(Plasmodium falciparum)
Homologues of p-T182-MAPKAPK5 [nucleoplasm]
(Plasmodium falciparum)
phospho-Mapkapk5 [nucleoplasm]
(Rattus norvegicus)
phospho-mapkapk5 [nucleoplasm]
(Danio rerio)
phospho-MAPKAPK5 [nucleoplasm]
(Bos taurus)
phospho-MAPKAPK5 [nucleoplasm]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-threonine at 182
Coordinate
182
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_620777.1
,
NP_003659.2
ZINC - World Drugs
MAPK5_HUMAN
Guide to Pharmacology - Targets
2096
OpenTargets
ENSG00000089022
ZINC - Substances
MAPK5_HUMAN
ZINC target
Q8IW41
ZINC - Biogenic
MAPK5_HUMAN
PRO
Q8IW41
ZINC - Investigational
MAPK5_HUMAN
HPA
ENSG00000089022-MAPKAPK5
GeneCards
Q8IW41
Ensembl
ENST00000550735
,
ENST00000551404
,
ENSP00000449667
,
ENSG00000089022
,
ENSP00000449381
Pharos - Targets
Q8IW41
ZINC - Predictions - Purchasable
MAPK5_HUMAN
HMDB Protein
HMDBP01196
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16659 MAPK6 gene
6
ub-MAPK6 [cytosol]
(R-HSA-5687000)
MAPK6 [cytosol]
(R-HSA-5686979)
p-S189 MAPK6 [cytosol]
(R-HSA-5687019)
p-S189 MAPK6 [nucleoplasm]
(R-HSA-5687015)
MAPK6 [nucleoplasm]
(R-HSA-5692686)
p-3S,T MAPK6 [nucleoplasm]
(R-HSA-5692665)
0.917
12
UniProt:Q15109 AGER
1
AGER [plasma membrane]
(R-HSA-197639)
0.655
6
UniProt:P31152 MAPK4
4
MAPK4 [nucleoplasm]
(R-HSA-5686975)
MAPK4 [cytosol]
(R-HSA-5686973)
p-S186 MAPK4 [cytosol]
(R-HSA-5687023)
p-S186 MAPK4 [nucleoplasm]
(R-HSA-5687022)
0.643
5
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