Reactome | SETD1A [nucleoplasm]

SETD1A [nucleoplasm]

Stable Identifier

R-HSA-3239027

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone-lysine N-methyltransferase SETD1A, SET1A_HUMAN, KMT2F

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Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- Epigenetic regulation of gene expression (Homo sapiens)
  - Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
    - Formation of WDR5-containing histone-modifying complexes (Homo sapiens)
      - BOD1L1 binds SET1A complex (Homo sapiens)
        
        BOD1L1:SET1A complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
        
        SET1A complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        SET1A complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
      - CXXC1 and WDR82 bind SET1A complex (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        SET1A complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
      - Formation of the SET1A complex (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
      - HCFC1 binds SET1A complex (Homo sapiens)
        
        SET1A complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        SET1A complex:WDR82:CXXC1:HCFC1 [nucleoplasm] (Homo sapiens)
        
        SET1A complex:WDR82:CXXC1 [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function (Homo sapiens)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter (Homo sapiens)
        
        H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        GP1BA gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
        
        H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        ITGA2B gene transcription is stimulated by the complex of RUNX1, GATA1 and PRMT1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
        
        H3K4me3-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        MIR27A gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
        
        H3K4me3-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        RUNX1 and GATA1 bind the promoter of the GP1BA gene (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        RUNX1 and GATA1 bind the promoter of the ITGA2B gene (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        H3K4me2-Nucleosome:ITGA2B gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        RUNX1 and GATA1 bind the promoter of the MIR27A gene (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        H3K4me2-Nucleosome:MIR27A gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        RUNX1 and GATA1 bind the promoter of the THBS1 gene (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        H3K4me2-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        THBS1 gene transcription is stimulated by the complex containing RUNX1, PRMT1 and GATA1 and inhibited by the complex of RUNX1, SIN3A and PRMT6 (Homo sapiens)
        
        H3K4me3-Nucleosome:THBS1 gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)
        
        RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm] (Homo sapiens)
        
        Core MLL complex [nucleoplasm] (Homo sapiens)
        
        SET1A complex [nucleoplasm] (Homo sapiens)
        
        SETD1A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O15047 SETD1A

Gene Names

SETD1A, KIAA0339, KMT2F, SET1, SET1A

Chain

chain:1-1707

Reference Genes

BioGPS Gene:9739 SETD1A

COSMIC (genes):SETD1A SETD1A

CTD Gene:9739 SETD1A

dbSNP Gene:9739 SETD1A

ENSEMBL:ENSG00000099381 SETD1A

ENSEMBL_homo_sapiens_GENE:ENSG00000099381.20 SETD1A

HGNC:29010 SETD1A

KEGG Gene (Homo sapiens):9739 SETD1A

Monarch:9739 SETD1A

NCBI Gene:9739 SETD1A

OMIM:611052 SETD1A

UCSC:O15047 SETD1A

Reference Transcript

Other Identifiers

11720128_at

16818090

213202_PM_at

213202_at

3656684

3656685

3656686

3656687

3656688

3656689

3656690

3656691

3656693

3656694

3656695

3656696

3656697

3656698

3656699

3656700

3656701

3656702

3656703

3656704

3656705

3656706

3656707

3656708

3656709

3656710

3656712

3656713

3656714

3656717

3656718

3656719

3656720

3656721

3656722

3656723

3656724

3656725

3656726

3656727

3656729

3656730

3656731

3656732

3656733

3656734

3656735

3656736

3656738

41464_at

7994985

9739

A_33_P3234103

GE53066

GO:0000785

GO:0003676

GO:0003723

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006325

GO:0006338

GO:0006974

GO:0007420

GO:0008013

GO:0008168

GO:0016607

GO:0016740

GO:0030154

GO:0032259

GO:0035097

GO:0036211

GO:0042800

GO:0043226

GO:0048188

GO:0048856

GO:0051568

GO:0061629

GO:0140096

GO:0140945

GO:0140999

GO:1902036

GO:1902275

HMNXSV003010447

Hs.112078.0.S1_3p_at

ILMN_1714327

PH_hs_0023573

TC16000364.hg

Participates

as an input of

Formation of the SET1A complex (Homo sapiens)

as a component of

SET1A complex [nucleoplasm] (Homo sapiens)

Inferred To

SETD1A [nucleoplasm] (Bos taurus)

SETD1A [nucleoplasm] (Caenorhabditis elegans)

SETD1A [nucleoplasm] (Canis familiaris)

SETD1A [nucleoplasm] (Dictyostelium discoideum)

SETD1A [nucleoplasm] (Drosophila melanogaster)

SETD1A [nucleoplasm] (Mus musculus)

SETD1A [nucleoplasm] (Saccharomyces cerevisiae)

SETD1A [nucleoplasm] (Schizosaccharomyces pombe)

SETD1A [nucleoplasm] (Sus scrofa)

Setd1a [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

XP_006721169.1, XP_016879398.1, NP_055527.1, XP_005255780.1

Guide to Pharmacology - Targets

2700

OpenTargets

ENSG00000099381

IntEnz

2.1.1.364

HPA

ENSG00000099381-SETD1A

GeneCards

O15047

Ensembl

ENSG00000099381, ENSP00000262519, ENSP00000507683, ENST00000262519, ENST00000684162

PRO

O15047

Pharos - Targets

O15047

Orphanet

25730

HMDB Protein

HMDBP01734

PDB

3UVN, 4EWR, 3S8S, 8ILY

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61964 WDR5	1	WDR5 [nucleoplasm] (R-HSA-1629838)	0.837	7
UniProt:Q9UBL3 ASH2L	1	ASH2L [nucleoplasm] (R-HSA-1629834)	0.69	4
UniProt:Q9P0U4 CXXC1	1	CXXC1 [nucleoplasm] (R-HSA-535610)	0.69	6
UniProt:Q15291 RBBP5	1	RBBP5 [nucleoplasm] (R-HSA-1629836)	0.662	5
UniProt:Q02248 Ctnnb1	14	phospho-Ctnnb1 [cytosol] (R-MMU-3134933) phospho-Ctnnb1 [nucleoplasm] (R-MMU-3134926) Ctnnb1 [plasma membrane] (R-MMU-9761458) Ctnnb1 [plasma membrane] (R-MMU-9038440) Ctnnb1 [nucleoplasm] (R-MMU-3451168) Ctnnb1 [cytosol] (R-MMU-448839) Ctnnb1 [cytosol] (R-MMU-202930) Ctnnb1 [cytosol] (R-MMU-202950) Ctnnb1 [nucleoplasm] (R-MMU-9735212) phospho-Ctnnb1 [cytosol] (R-MMU-8942374) beta-catenin [cytosol] (R-MMU-206225) phospho-Ctnnb1 [cytosol] (R-MMU-8942369) phospho-Ctnnb1 [cytosol] (R-MMU-8942367) phospho-Ctnnb1 [cytosol] (R-MMU-8942363)	0.544	2
UniProt:P10242 MYB	1	MYB [nucleoplasm] (R-HSA-992697)	0.536	2
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.532	4
UniProt:Q5VWQ0 RSBN1			0.527	2
UniProt:O00541 PES1	1	PES1 [nucleoplasm] (R-HSA-6791207)	0.527	2
UniProt:Q9C005 DPY30	1	DPY30 [nucleoplasm] (R-HSA-5669104)	0.527	2
UniProt:Q9Y2J2 EPB41L3	1	EPB41L3 [cytosol] (R-HSA-6797563)	0.527	2
UniProt:P55345 ANM2			0.527	3
UniProt:Q9Y5Z7 HCFC2	1	HCFC2 [nucleoplasm] (R-HSA-9821232)	0.527	4
UniProt:O43491 EPB41L2	1	EPB41L2 [cytosol] (R-HSA-6797548)	0.527	2
UniProt:P21741 MDK	1	MDK [extracellular region] (R-HSA-2160953)	0.527	2
UniProt:Q6UXN9 WDR82	1	WDR82 [nucleoplasm] (R-HSA-9821474)	0.527	3
UniProt:O15294 OGT	2	OGT [nucleoplasm] (R-HSA-3321845) OGT [cytosol] (R-HSA-9687814)	0.527	2
UniProt:Q9UBL3-3 ASH2L			0.499	2
UniProt:P51610 HCFC1	2	HCFC1 [nucleoplasm] (R-HSA-1592209) K48polyUb,K63polyUb-HCFC1 [nucleoplasm] (R-HSA-5690821)	0.499	2

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