E2F1/2/3:DP1/2 binds EZH2 gene promoter

Stable Identifier
R-HSA-3240777
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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E2F1/2/3:DP1/2 binds EZH2 gene promoter
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EZH2 gene contains several E2F binding sites in its promoter, and these E2F-binding sites are needed for the responsiveness of EZH2 promoter to E2F1, E2F2 and E2F3. Only E2F1 with intact DNA-binding domain stimulates EZH2 transcription. Binding of E2F3 to EZH2 promoter was directly demonstrated by ChIP (Bracken et al. 2003).
Literature References
PubMed ID Title Journal Year
14532106 EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer

Helin, K, Bracken, AP, Prosperini, E, Capra, M, Colli, E, Pasini, D

EMBO J. 2003
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Authored
Orlic-Milacic, M  (2013-07-15)
Reviewed
Samarajiwa, S  (2013-09-03)
Created
Orlic-Milacic, M  (2013-03-28)
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