Reactome | PIAS1 SUMOylates SP3 with SUMO1

PIAS1 SUMOylates SP3 with SUMO1

Stable Identifier

R-HSA-3247493

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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PIAS1 SUMOylates SP3 with SUMO1 at lysine-551 (Ross et al. 2002, Sapetschnig et al. 2002, Sapetschnig et al. 2004, Spengler et al. 2005, Ellis et al. 2006, Impens et al. 2014). A minor amount of SUMOylation is also observed at lysine-120 (Ross et al. 2002). The effects of SUMOylation on the activities of isoforms of SP3 are promoter-dependent (Sapetschnig et al. 2004). Generally SUMOylation reduces the transcription activation capacity of the long and the short isoforms of Sp3 (Ross et al. 2002, Sapetschnig et al 2004, Ellis et al 2006). Mechanistically, SUMO attachment to Sp3 serves as a molecular beacon for the recruitment of chromatin-modifying machineries that impose epigenetic silencing (inferred from Drosophila homologs in Stielow et al. 2008a, inferred from mouse homologs in Stielow et al. 2008b).

Literature References

PubMed ID	Title	Journal	Year
12356736	Transcription factor Sp3 is silenced through SUMO modification by PIAS1 Sapetschnig, A, Rischitor, G, Braun, H, Doll, A, Schergaut, M, Melchior, F, Suske, G	EMBO J.	2002
18617891	SUMO-modified Sp3 represses transcription by provoking local heterochromatic gene silencing Stielow, B, Sapetschnig, A, Wink, C, Krüger, I, Suske, G	EMBO Rep.	2008
18374648	Identification of SUMO-dependent chromatin-associated transcriptional repression components by a genome-wide RNAi screen Stielow, B, Sapetschnig, A, Krüger, I, Kunert, N, Brehm, A, Boutros, M, Suske, G	Mol. Cell	2008
15247228	Complexity of translationally controlled transcription factor Sp3 isoform expression Sapetschnig, A, Koch, F, Rischitor, G, Mennenga, T, Suske, G	J. Biol. Chem.	2004
12419227	SUMO-1 modification represses Sp3 transcriptional activation and modulates its subnuclear localization Ross, S, Best, JL, Zon, LI, Gill, G	Mol. Cell	2002
16781829	The modification of Sp3 isoforms by SUMOylation has differential effects on the SRC1A promoter Ellis, DJ, Dehm, SM, Bonham, K	Gene	2006
25114211	Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli Impens, F, Radoshevich, L, Cossart, P, Ribet, D	Proc. Natl. Acad. Sci. U.S.A.	2014
15494207	Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism Spengler, ML, Kennett, SB, Moorefield, KS, Simmons, SO, Brattain, MG, Horowitz, JM	Cell. Signal.	2005