Reactome | WLS [early endosome membrane]

WLS [early endosome membrane]

Stable Identifier

R-HSA-3247745

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome membrane

Synonyms

GPR177, EVI

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External Reference Information

External Reference

UniProt:Q5T9L3 WLS

Gene Names

WLS, C1orf139, GPR177, UNQ85/PRO18667

Chain

chain:1-541

Reference Genes

BioGPS Gene:79971 WLS

COSMIC (genes):WLS WLS

CTD Gene:79971 WLS

dbSNP Gene:79971 WLS

ENSEMBL:ENSG00000116729 WLS

HGNC:30238 WLS

KEGG:hsa:79971 WLS

Monarch:79971 WLS

NCBI Gene:79971 WLS

OMIM:611514 WLS

UCSC:Q5T9L3 WLS

Reference Transcript

Participates

as a component of

WLS:retromer [early endosome membrane] (Homo sapiens)

as an input of

Retromer associates with WLS (Homo sapiens)

as an output of

WLS is endocytosed to the early endosome (Homo sapiens)

Other forms of this molecule

WLS [plasma membrane]

WLS [Golgi membrane]

WLS [endocytic vesicle membrane]

WLS [extracellular exosome]

Inferred To

mig-14 [early endosome membrane] (Caenorhabditis elegans)

WLS [early endosome membrane] (Bos taurus)

WLS [early endosome membrane] (Canis familiaris)

WLS [early endosome membrane] (Gallus gallus)

WLS [early endosome membrane] (Sus scrofa)

wls [early endosome membrane] (Drosophila melanogaster)

wls [early endosome membrane] (Xenopus tropicalis)

Ghost homologue of WLS [early endosome membrane] (Dictyostelium discoideum)

Ghost homologue of WLS [early endosome membrane] (Saccharomyces cerevisiae)

Ghost homologue of WLS [early endosome membrane] (Schizosaccharomyces pombe)

Wls [early endosome membrane] (Mus musculus)

Wls [early endosome membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_079187.3, NP_001002292.3, NP_001180263.1

OpenTargets

ENSG00000116729

ENSEMBL

ENSP00000262348, ENST00000262348, ENST00000370976, ENSP00000360015, ENSG00000116729, ENST00000354777, ENSP00000346829

HPA

ENSG00000116729-WLS

GeneCards

WLS

PRO

Q5T9L3

Pharos - Targets

Q5T9L3

PDB

8TZP, 8TZR, 7DRT, 7KC4, 8TZS, 8TZO

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.819	11
UniProt:P56704 WNT3A	10	N4GlycoAsn-PalmS WNT3A [plasma membrane] (R-HSA-3247807) N4GlycoAsn-PalmS WNT3A [extracellular region] (R-HSA-3247784) N4GlycoAsn-PalmS WNT3A [Golgi lumen] (R-HSA-3247832) N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen] (R-HSA-3238344) N4GlycoAsn-WNT3A [endoplasmic reticulum lumen] (R-HSA-3238231) WNT3A [endoplasmic reticulum lumen] (R-HSA-3238292) N4GlycoAsn-PalmS WNT3A [early endosome membrane] (R-HSA-5368483) N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane] (R-HSA-3781944) N4GlycoAsn-PalmS WNT3A [extracellular exosome] (R-HSA-3781968) WNT3A [extracellular region] (R-HSA-201710)	0.784	6
UniProt:P41221 WNT5A	10	N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] (R-HSA-3247777) N4GlycoAsn-PalmS WNT5A(36-380) [plasma membrane] (R-HSA-3247799) N4GlycoAsn-PalmS WNT5A(36-380) [Golgi lumen] (R-HSA-3247788) N4GlycoAsn-PalmS WNT5A(36-380) [endoplasmic reticulum lumen] (R-HSA-3238371) N4GlycoAsn-WNT5A(36-380) [endoplasmic reticulum lumen] (R-HSA-3238239) WNT5A(36-380) [endoplasmic reticulum lumen] (R-HSA-3238300) N4GlycoAsn-PalmS WNT5A(36-380) [endocytic vesicle membrane] (R-HSA-3781982) N4GlycoAsn-PalmS WNT5A(36-380) [extracellular exosome] (R-HSA-3781973) N4GlycoAsn-PalmS WNT5A(36-380) [clathrin-coated endocytic vesicle membrane] (R-HSA-5138454) WNT5A [extracellular region] (R-HSA-517396)	0.564	3
UniProt:O00755 WNT7A	9	WNT7A [extracellular region] (R-HSA-517404) N4GlycoAsn-PalmS WNT7A [extracellular exosome] (R-HSA-3781951) N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane] (R-HSA-3781961) WNT7A [endoplasmic reticulum lumen] (R-HSA-3238312) N4GlycoAsn-WNT7A [endoplasmic reticulum lumen] (R-HSA-3238249) N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen] (R-HSA-3238354) N4GlycoAsn-PalmS WNT7A [Golgi lumen] (R-HSA-3247778) N4GlycoAsn-PalmS WNT7A [extracellular region] (R-HSA-3247774) N4GlycoAsn-PalmS WNT7A [plasma membrane] (R-HSA-3247833)	0.564	3
UniProt:Q1HG44 DOXA2			0.527	2
UniProt:P11230 ACHB			0.527	2
UniProt:Q8IVM8 S22A9			0.527	2
UniProt:P43681 CHRNA4	1	CHRNA4 [plasma membrane] (R-HSA-507836)	0.527	2
UniProt:P56705 WNT4	9	WNT4 [extracellular region] (R-HSA-517385) N4GlycoAsn-PalmS WNT4 [extracellular exosome] (R-HSA-3781964) N4GlycoAsn-PalmS WNT4 [endocytic vesicle membrane] (R-HSA-3781978) WNT4 [endoplasmic reticulum lumen] (R-HSA-3238297) N4GlycoAsn-WNT4 [endoplasmic reticulum lumen] (R-HSA-3238235) N4GlycoAsn-PalmS WNT4 [endoplasmic reticulum lumen] (R-HSA-3238347) N4GlycoAsn-PalmS WNT4 [Golgi lumen] (R-HSA-3247779) N4GlycoAsn-PalmS WNT4 [extracellular region] (R-HSA-3247794) N4GlycoAsn-PalmS WNT4 [plasma membrane] (R-HSA-3247809)	0.527	3
UniProt:Q01959 SLC6A3	5	SLC6A3 [plasma membrane] (R-HSA-379482) SLC6A3 L368Q [plasma membrane] (R-HSA-5660710) SLC6A3 L224P [plasma membrane] (R-HSA-5660718) SLC6A3 P395L [plasma membrane] (R-HSA-5660716) SLC6A3 R521W [plasma membrane] (R-HSA-5660729)	0.524	2