Reactome | WLS [early endosome membrane]

WLS [early endosome membrane]

Stable Identifier

R-HSA-3247745

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

early endosome membrane

Synonyms

GPR177, EVI

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Locations in the PathwayBrowser for interactor UniProt:P35372 OPRM1

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External Reference Information

External Reference

UniProt:Q5T9L3 WLS

Gene Names

WLS, C1orf139, GPR177, UNQ85/PRO18667

Chain

chain:1-541

Reference Genes

COSMIC (genes):WLS WLS

dbSNP Gene:79971 WLS

ENSEMBL:ENSG00000116729 WLS

Participates

as a component of

WLS:retromer [early endosome membrane] (Homo sapiens)

as an input of

Retromer associates with WLS (Homo sapiens)

as an output of

WLS is endocytosed to the early endosome (Homo sapiens)

Other forms of this molecule

WLS [extracellular exosome]

WLS [endocytic vesicle membrane]

WLS [Golgi membrane]

WLS [plasma membrane]

Inferred To

mig-14 [early endosome membrane] (Caenorhabditis elegans)

WLS [early endosome membrane] (Bos taurus)

WLS [early endosome membrane] (Canis familiaris)

WLS [early endosome membrane] (Gallus gallus)

WLS [early endosome membrane] (Sus scrofa)

wls [early endosome membrane] (Drosophila melanogaster)

wls [early endosome membrane] (Xenopus tropicalis)

Ghost homologue of WLS [early endosome membrane] (Dictyostelium discoideum)

Ghost homologue of WLS [early endosome membrane] (Saccharomyces cerevisiae)

Ghost homologue of WLS [early endosome membrane] (Schizosaccharomyces pombe)

Wls [early endosome membrane] (Mus musculus)

Wls [early endosome membrane] (Rattus norvegicus)

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.819	11
UniProt:P56704 WNT3A	10	N4GlycoAsn-PalmS WNT3A [plasma membrane] (R-HSA-3247807) N4GlycoAsn-PalmS WNT3A [extracellular region] (R-HSA-3247784) N4GlycoAsn-PalmS WNT3A [Golgi lumen] (R-HSA-3247832) N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen] (R-HSA-3238344) N4GlycoAsn-WNT3A [endoplasmic reticulum lumen] (R-HSA-3238231) WNT3A [endoplasmic reticulum lumen] (R-HSA-3238292) N4GlycoAsn-PalmS WNT3A [early endosome membrane] (R-HSA-5368483) N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane] (R-HSA-3781944) N4GlycoAsn-PalmS WNT3A [extracellular exosome] (R-HSA-3781968) WNT3A [extracellular region] (R-HSA-201710)	0.721	5
UniProt:P41221 WNT5A	10	N4GlycoAsn-PalmS WNT5A(36-380) [extracellular region] (R-HSA-3247777) N4GlycoAsn-PalmS WNT5A(36-380) [plasma membrane] (R-HSA-3247799) N4GlycoAsn-PalmS WNT5A(36-380) [Golgi lumen] (R-HSA-3247788) N4GlycoAsn-PalmS WNT5A(36-380) [endoplasmic reticulum lumen] (R-HSA-3238371) N4GlycoAsn-WNT5A(36-380) [endoplasmic reticulum lumen] (R-HSA-3238239) WNT5A(36-380) [endoplasmic reticulum lumen] (R-HSA-3238300) N4GlycoAsn-PalmS WNT5A(36-380) [extracellular exosome] (R-HSA-3781973) N4GlycoAsn-PalmS WNT5A(36-380) [clathrin-coated endocytic vesicle membrane] (R-HSA-5138454) N4GlycoAsn-PalmS WNT5A(36-380) [endocytic vesicle membrane] (R-HSA-3781982) WNT5A [extracellular region] (R-HSA-517396)	0.564	3
UniProt:O00755 WNT7A	9	WNT7A [extracellular region] (R-HSA-517404) N4GlycoAsn-PalmS WNT7A [extracellular exosome] (R-HSA-3781951) N4GlycoAsn-PalmS WNT7A [endocytic vesicle membrane] (R-HSA-3781961) WNT7A [endoplasmic reticulum lumen] (R-HSA-3238312) N4GlycoAsn-WNT7A [endoplasmic reticulum lumen] (R-HSA-3238249) N4GlycoAsn-PalmS WNT7A [endoplasmic reticulum lumen] (R-HSA-3238354) N4GlycoAsn-PalmS WNT7A [Golgi lumen] (R-HSA-3247778) N4GlycoAsn-PalmS WNT7A [extracellular region] (R-HSA-3247774) N4GlycoAsn-PalmS WNT7A [plasma membrane] (R-HSA-3247833)	0.564	3
UniProt:Q01959 SLC6A3	5	SLC6A3 [plasma membrane] (R-HSA-379482) SLC6A3 L368Q [plasma membrane] (R-HSA-5660710) SLC6A3 L224P [plasma membrane] (R-HSA-5660718) SLC6A3 P395L [plasma membrane] (R-HSA-5660716) SLC6A3 R521W [plasma membrane] (R-HSA-5660729)	0.524	2