Reactome | WNT ligands traffic to the Golgi

WNT ligands traffic to the Golgi

Stable Identifier

R-HSA-3247837

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

Golgi lumen, endoplasmic reticulum lumen

ReviewStatus

5/5

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This black box event represents the non-WNT-specific ER-to-Golgi trafficking step of protein secretion (reviewed in Dancourt and Barlowe, 2010; Lippincott Schwatz et al, 2000; for more details, please refer to the pathway "ER to Golgi transport"). Two recent screens in Drosophila have identified members of the p24 family as WNT-specific regulators of ER-to-Golgi transport, although the details have not been elucidated (Port et al, 2011; Buechling et al, 2011; reviewed in Strating and Martens, 2009). Depletion of the Drosophila p24 protein Opossum causes accumulation of WNT ligand in the ER, suggesting a role for Opm in ER-to-Golgi transport of WNTs. WNT-dependent reporter activity was reduced in HEK293 cells that were depleted for the human p24 homologue TMED5, supporting a conserved role for these proteins in WNT signaling (Buechling et al, 2011; reviewed in Palmer et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
22094269	p24 proteins are required for secretion of Wnt ligands Boutros, M, Weiss, M, Buechling, T, Spirohn, K, Chaudhary, V	EMBO Rep.	2011
20533886	Protein sorting receptors in the early secretory pathway Dancourt, J, Barlowe, C	Annu. Rev. Biochem.	2010
22094272	Wnts need a p(assport)24 to leave the ER Palmer, L, Beckett, K, Vincent, JP	EMBO Rep.	2011
11031247	Secretory protein trafficking and organelle dynamics in living cells Lippincott-Schwartz, J, Roberts, TH, Hirschberg, K	Annu Rev Cell Dev Biol	2000
21886182	A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion Port, F, Hausmann, G, Basler, K	EMBO Rep.	2011
19566487	The p24 family and selective transport processes at the ER-Golgi interface Strating, JR, Martens, GJ	Biol. Cell	2009