Reactome | K63polyUb-STING [cytoplasmic vesicle membrane]

K63polyUb-STING [cytoplasmic vesicle membrane]

Stable Identifier

R-HSA-3248021

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytoplasmic vesicle membrane

Synonyms

MITA, TMEM173, ERIS

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External Reference Information

External Reference

UniProt:Q86WV6 TMEM173

Gene Names

TMEM173, ERIS, MITA, STING

Chain

chain:1-379

Reference Genes

BioGPS Gene:340061 TMEM173

COSMIC (genes):TMEM173 TMEM173

CTD Gene:340061 TMEM173

dbSNP Gene:340061 TMEM173

ENSEMBL:ENSG00000184584 TMEM173

HGNC:27962 TMEM173

KEGG Gene (Homo sapiens):340061 TMEM173

Monarch:340061 TMEM173

NCBI Gene:340061 TMEM173

OMIM:612374 TMEM173

UCSC:Q86WV6 TMEM173

Reference Transcript

RefSeq:NM_198282.3 TMEM173

Other Identifiers

0001410398

11727044_a_at

17000650

224916_at

224929_at

2877991

2877992

2877993

2877994

2877995

2877998

2878000

2878002

2878003

2878004

2878005

2878006

2878007

2878008

2878009

340061

38116

38534

4EF4

4EF5

4EMT

4EMU

4F5D

4F5E

4F5W

4F5Y

4F9E

4F9G

4KSY

4LOH

4LOI

4QXO

4QXP

4QXQ

4QXR

5BQX

5JEJ

65817_at

6CFF

6CY7

6DNK

6MX0

6MX3

6MXE

6NT5

8114536

A0A494C0T1

A0A494C0W5

A0A494C1N5

A_23_P61371

AAH47779

AC138517

ACI46648

AK290661

BAF83350

BC047779

CCDS4215

ENSG00000184584

ENSP00000331288

ENSP00000498596

ENSP00000498768

ENSP00000499166

ENST00000330794

ENST00000330794.8

ENST00000651565

ENST00000651699

ENST00000652271

EntrezGene:340061

EntrezGene:TMEM173

FJ222241

GE88570

GO:0000045

GO:0000166

GO:0000421

GO:0002218

GO:0002230

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005739

GO:0005741

GO:0005768

GO:0005773

GO:0005776

GO:0005783

GO:0005789

GO:0005886

GO:0006810

GO:0006914

GO:0006950

GO:0007165

GO:0008134

GO:0008150

GO:0009056

GO:0009058

GO:0016020

GO:0016021

GO:0016032

GO:0016192

GO:0016239

GO:0019899

GO:0019901

GO:0022607

GO:0030176

GO:0030659

GO:0030667

GO:0031410

GO:0032092

GO:0032479

GO:0032481

GO:0032608

GO:0033116

GO:0034641

GO:0035438

GO:0039528

GO:0042802

GO:0042803

GO:0043167

GO:0043226

GO:0043312

GO:0044403

GO:0045087

GO:0045944

GO:0048471

GO:0051091

GO:0051259

GO:0051607

GO:0061507

GO:0061709

GO:0065003

GO:0071360

GO:0071407

GO:1990701

HGNC:27962

HPA038116

HPA038534

Hs.86347.1.A1_3p_at

Hs.86347.1.A2_3p_at

ILMN_1761447

ILMN_2145116

IPR029158

IPR033952

IPR038623

J3QTB1

LRG_1308

LRG_1308t1

MIM:612374

MIM:615934

NM_198282

NP_938023

PF15009

PH_hs_0033001

TC05001845.hg

TMEM173

TMEM173-201

TMEM173-218

TMEM173-220

UPI000000DC5E

Participant Of

hasComponent

STING:STING [cytoplasmic vesicle membrane]

Other forms of this molecule

TMEM173 [plasma membrane]

TMEM173 [secretory granule membrane]

K63polyUb-STING [endoplasmic reticulum membrane]

TMEM173 [endoplasmic reticulum membrane]

Inferred To

K63polyUb-STING [cytoplasmic vesicle membrane] (Bos taurus)

K63polyUb-STING [cytoplasmic vesicle membrane] (Canis familiaris)

K63polyUb-STING [cytoplasmic vesicle membrane] (Danio rerio)

K63polyUb-STING [cytoplasmic vesicle membrane] (Gallus gallus)

K63polyUb-STING [cytoplasmic vesicle membrane] (Mus musculus)

K63polyUb-STING [cytoplasmic vesicle membrane] (Rattus norvegicus)

K63polyUb-STING [cytoplasmic vesicle membrane] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at 150

Coordinate

150

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_938023.1

OpenTargets

ENSG00000184584

GeneCards

Q86WV6

PRO

Q86WV6

Orphanet

23359

PDB

6CY7, 6CFF, 6DXG, 6MX0, 5JEJ, 4EMU, 5BQX, 4EF5, 4F5Y, 6DNK, 6MX3, 4QXR, 4LOI, 6DXL, 6O8B, 4LOH, 4EMT, 4KSY, 4QXQ, 4F9G, 4EF4, 4F5W, 6O8C, 4QXP, 4F9E, 4QXO, 6MXE, 6NT5, 4F5E, 4F5D

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q86WV6 TMEM173	5	TMEM173 [secretory granule membrane] (R-HSA-6804798) TMEM173 [plasma membrane] (R-HSA-6804815) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) TMEM173 [endoplasmic reticulum membrane] (R-HSA-1834940)	0.933	12
UniProt:Q9UHD2 TBK1	6	p-S172-TBK1 [endosome membrane] (R-HSA-450290) p-S172-TBK1 [plasma membrane] (R-HSA-936983) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) TBK1 [cytosol] (R-HSA-166267) p-S172-TBK1 [cytosol] (R-HSA-168379)	0.862	8
UniProt:Q7Z434-1 MAVS			0.78	7
UniProt:Q7Z434 MAVS	2	K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463) MAVS [mitochondrial outer membrane] (R-HSA-913730)	0.71	7
UniProt:P42226 STAT6	6	p-Y641-STAT6 [cytosol] (R-HSA-6786109) STAT6 [cytosol] (R-HSA-629625) p-Y641-STAT6 [nucleoplasm] (R-HSA-6786279) p-S407,Y641-STAT6 [cytosol] (R-HSA-3249376) p-S407,Y641-STAT6 [nucleoplasm] (R-HSA-3261241) p-S407-STAT6 [cytosol] (R-HSA-3249369)	0.631	12
UniProt:O15260 SURF4	5	SURF4 [transport vesicle] (R-HSA-6813919) SURF4 [Golgi membrane] (R-HSA-6813912) SURF4 [endoplasmic reticulum membrane] (R-HSA-6813914) SURF4 [plasma membrane] (R-HSA-6806264) SURF4 [azurophil granule membrane] (R-HSA-6799361)	0.623	3
ChEBI:75947 CG(2'5')			0.558	2
UniProt:P09914 IFIT1	1	IFIT1 [cytosol] (R-HSA-937341)	0.558	3
ChEBI:75948 CG(2'5')			0.558	2
UniProt:P09913 IFIT2	1	IFIT2 [cytosol] (R-HSA-1015674)	0.558	3
UniProt:P27958-PRO_0000037575			0.543	5
UniProt:O95786-1 DDX58			0.524	2
UniProt:Q16666 IFI16	1	IFI16 [cytosol] (R-HSA-1834934)	0.524	2
UniProt:P46977 STT3A	1	STT3A [endoplasmic reticulum membrane] (R-HSA-265023)	0.499	2
UniProt:P39656 DDOST	3	DDOST [azurophil granule membrane] (R-HSA-6799145) DDOST [plasma membrane] (R-HSA-879386) DDOST [endoplasmic reticulum membrane] (R-HSA-264963)	0.499	2
UniProt:O95470 SGPL1	1	PXLP-SGPL1 [endoplasmic reticulum membrane] (R-HSA-428661)	0.499	2
UniProt:P51617 IRAK1	14	p-S,T-IRAK1 [cytosol] (R-HSA-3149574) K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) IRAK1 [cytosol] (R-HSA-446639) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) IRAK1 [plasma membrane] (R-HSA-937045) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) IRAK1 [endosome membrane] (R-HSA-975127)	0.499	2
UniProt:O94822 LTN1	1	LTN1 [cytosol] (R-HSA-5688967)	0.499	2
UniProt:Q96A33 CCD47			0.499	2
UniProt:Q96N66 MBOAT7	1	MBOAT7 [endoplasmic reticulum membrane] (R-HSA-1498778)	0.499	2
UniProt:Q96HR9-2 REEP6			0.488	2
UniProt:Q9Y342 PLLP			0.488	2
UniProt:O95214 LERL1			0.488	2
UniProt:Q13190 STX5	5	STX5 [endoplasmic reticulum membrane] (R-HSA-5689474) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [cytosol] (R-HSA-9613991)	0.488	2
UniProt:P43308 SSR2	1	SSR2 [endoplasmic reticulum membrane] (R-HSA-265061)	0.482	4
UniProt:Q99IB8-PRO_0000045601			0.463	5