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K63polyUb-STING [cytoplasmic vesicle membrane]
Stable Identifier
R-HSA-3248021
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytoplasmic vesicle membrane
Synonyms
MITA, TMEM173, ERIS
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
Regulation of innate immune responses to cytosolic DNA (Homo sapiens)
DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3 (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172,K48polyUb-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
NLRP4 and DTX4 associate with p-S172-TBK1 within STING:TBK1:IRF3 (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
IRF3-mediated induction of type I IFN (Homo sapiens)
IRF3 is phosphorylated by TBK1 (Homo sapiens)
NLRP4:DTX4:STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING recruits TBK1 and IRF3 (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
TBK1 is phosphorylated within STING:TBK1:IRF3 complex (Homo sapiens)
STING:TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:IRF3 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
STAT6-mediated induction of chemokines (Homo sapiens)
STING recruits TBK1 and STAT6 (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:TBK1:STAT6 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
TBK1 is phosphorylated within STING:TBK1:STAT6 complex (Homo sapiens)
STING:TBK1:STAT6 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
TBK1 phosphorylates STAT6 at Ser407 (Homo sapiens)
STING:p-S172-TBK1 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING:p-S172-TBK1:STAT6 [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING binds c-di-GMP (Homo sapiens)
STING:c-di-GMP [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
STING binds cyclic GMP-AMP (Homo sapiens)
STING:cGAMP [cytoplasmic vesicle membrane] (Homo sapiens)
STING:STING [cytoplasmic vesicle membrane] (Homo sapiens)
K63polyUb-STING [cytoplasmic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86WV6 TMEM173
Gene Names
TMEM173, ERIS, MITA, STING
Chain
chain:1-379
Reference Genes
BioGPS Gene:340061 TMEM173
COSMIC (genes):TMEM173 TMEM173
CTD Gene:340061 TMEM173
dbSNP Gene:340061 TMEM173
ENSEMBL:ENSG00000184584 TMEM173
HGNC:27962 TMEM173
KEGG Gene (Homo sapiens):340061 TMEM173
Monarch:340061 TMEM173
NCBI Gene:340061 TMEM173
OMIM:612374 TMEM173
UCSC:Q86WV6 TMEM173
Reference Transcript
RefSeq:NM_198282.3 TMEM173
Other Identifiers
0001410398
11727044_a_at
17000650
224916_at
224929_at
2877991
2877992
2877993
2877994
2877995
2877998
2878000
2878002
2878003
2878005
2878007
2878008
2878009
340061
38116
38534
4EF4
4EF5
4EMT
4EMU
4F5D
4F5E
4F5W
4F5Y
4F9E
4F9G
4KSY
4LOH
4LOI
4QXO
4QXP
4QXQ
4QXR
5BQX
5JEJ
65817_at
6MX0
6MX3
6MXE
8114536
A_23_P61371
AAH47779
AC138517
ACI46648
AK290661
BAF83350
BC047779
CCDS4215
ENSG00000184584
ENSP00000331288
ENST00000330794
ENST00000330794.8
EntrezGene:340061
EntrezGene:TMEM173
FJ222241
GE88570
GO:0000045
GO:0000166
GO:0000421
GO:0002218
GO:0002230
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005739
GO:0005741
GO:0005768
GO:0005773
GO:0005776
GO:0005783
GO:0005789
GO:0005886
GO:0006810
GO:0006914
GO:0006950
GO:0007165
GO:0008134
GO:0008150
GO:0009056
GO:0009058
GO:0016020
GO:0016021
GO:0016032
GO:0016192
GO:0016239
GO:0019899
GO:0019901
GO:0022607
GO:0030659
GO:0030667
GO:0031410
GO:0032092
GO:0032479
GO:0032481
GO:0032608
GO:0033116
GO:0034641
GO:0035438
GO:0039528
GO:0042802
GO:0042803
GO:0043167
GO:0043226
GO:0043312
GO:0044403
GO:0045087
GO:0045944
GO:0048471
GO:0051091
GO:0051259
GO:0051607
GO:0061507
GO:0061709
GO:0065003
GO:0071360
GO:0071407
GO:1990701
HGNC:27962
HPA038116
HPA038534
Hs.86347.1.A1_3p_at
Hs.86347.1.A2_3p_at
ILMN_1761447
ILMN_2145116
IPR029158
IPR033952
IPR038623
LRG_1308
MIM:612374
MIM:615934
NM_198282
NP_938023
PF15009
PH_hs_0033001
TC05001845.hg
TMEM173
TMEM173-201
UPI000000DC5E
Participant Of
hasComponent
STING:STING [cytoplasmic vesicle membrane]
Other forms of this molecule
TMEM173 [plasma membrane]
TMEM173 [secretory granule membrane]
K63polyUb-STING [endoplasmic reticulum membrane]
TMEM173 [endoplasmic reticulum membrane]
Inferred To
K63polyUb-STING [cytoplasmic vesicle membrane] (Bos taurus)
K63polyUb-STING [cytoplasmic vesicle membrane] (Canis familiaris)
K63polyUb-STING [cytoplasmic vesicle membrane] (Danio rerio)
K63polyUb-STING [cytoplasmic vesicle membrane] (Gallus gallus)
K63polyUb-STING [cytoplasmic vesicle membrane] (Mus musculus)
K63polyUb-STING [cytoplasmic vesicle membrane] (Rattus norvegicus)
K63polyUb-STING [cytoplasmic vesicle membrane] (Xenopus tropicalis)
Modified Residues
Name
ubiquitinylated lysine (K63polyUb [cytosol]) at 150
Coordinate
150
Modification
K63polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_938023.1
OpenTargets
ENSG00000184584
GeneCards
Q86WV6
PRO
Q86WV6
Orphanet
23359
PDB
4QXP
,
4QXQ
,
4F9G
,
4LOH
,
6MXE
,
4EF5
,
4F5W
,
4EF4
,
4KSY
,
4LOI
,
4EMT
,
4QXR
,
5BQX
,
4F5Y
,
6CFF
,
4F5D
,
6MX0
,
6CY7
,
6DXG
,
5JEJ
,
6DNK
,
6DXL
,
6MX3
,
4EMU
,
6O8C
,
4F5E
,
4QXO
,
6O8B
,
6NT5
,
4F9E
Interactors (26)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86WV6 TMEM173
5
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
TMEM173 [plasma membrane]
(R-HSA-6804815)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
TMEM173 [endoplasmic reticulum membrane]
(R-HSA-1834940)
0.933
12
UniProt:Q9UHD2 TBK1
6
p-S172-TBK1 [cytosol]
(R-HSA-168379)
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
p-TBK1 [cytosol]
(R-HSA-9008705)
TBK1 [cytosol]
(R-HSA-166267)
p-S172-TBK1 [endosome membrane]
(R-HSA-450290)
p-S172-TBK1 [plasma membrane]
(R-HSA-936983)
0.862
8
UniProt:Q7Z434-1 MAVS
0.78
7
UniProt:Q7Z434 MAVS
2
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
0.71
7
UniProt:P42226 STAT6
6
p-Y641-STAT6 [nucleoplasm]
(R-HSA-6786279)
p-Y641-STAT6 [cytosol]
(R-HSA-6786109)
STAT6 [cytosol]
(R-HSA-629625)
p-S407-STAT6 [cytosol]
(R-HSA-3249369)
p-S407,Y641-STAT6 [cytosol]
(R-HSA-3249376)
p-S407,Y641-STAT6 [nucleoplasm]
(R-HSA-3261241)
0.631
12
UniProt:O15260 SURF4
5
SURF4 [transport vesicle]
(R-HSA-6813919)
SURF4 [Golgi membrane]
(R-HSA-6813912)
SURF4 [endoplasmic reticulum membrane]
(R-HSA-6813914)
SURF4 [plasma membrane]
(R-HSA-6806264)
SURF4 [azurophil granule membrane]
(R-HSA-6799361)
0.623
3
ChEBI:75947 CG(2'5')
0.558
2
ChEBI:75948 CG(2'5')
0.558
2
UniProt:P09913 IFIT2
1
IFIT2 [cytosol]
(R-HSA-1015674)
0.558
3
UniProt:P09914 IFIT1
1
IFIT1 [cytosol]
(R-HSA-937341)
0.558
3
UniProt:P27958-PRO_0000037575
0.543
5
UniProt:Q16666 IFI16
1
IFI16 [cytosol]
(R-HSA-1834934)
0.524
2
UniProt:O95786-1 DDX58
0.524
2
UniProt:P46977 STT3A
1
STT3A [endoplasmic reticulum membrane]
(R-HSA-265023)
0.499
2
UniProt:P39656 DDOST
3
DDOST [plasma membrane]
(R-HSA-879386)
DDOST [endoplasmic reticulum membrane]
(R-HSA-264963)
DDOST [azurophil granule membrane]
(R-HSA-6799145)
0.499
2
UniProt:O95470 SGPL1
1
PXLP-SGPL1 [endoplasmic reticulum membrane]
(R-HSA-428661)
0.499
2
UniProt:P51617 IRAK1
14
p-S376,T387-IRAK1 [cytosol]
(R-HSA-446687)
K63polyUb-hp-IRAK1 [endosome membrane]
(R-HSA-975112)
K63polyUb-hp-IRAK1 [cytosol]
(R-HSA-451565)
IRAK1 [cytosol]
(R-HSA-446639)
p-2S,S376,T,T209,T387-IRAK1 [cytosol]
(R-HSA-446682)
p-2S,S376,T,T209,T387-IRAK1 [plasma membrane]
(R-HSA-937011)
p-T209,T387-IRAK1 [plasma membrane]
(R-HSA-166279)
p-T209-IRAK1 [plasma membrane]
(R-HSA-937031)
IRAK1 [plasma membrane]
(R-HSA-937045)
p-2S,S376,T,T209,T387-IRAK1 [endosome membrane]
(R-HSA-975157)
p-T209,T387-IRAK1 [endosome membrane]
(R-HSA-975117)
p-T209-IRAK1 [endosome membrane]
(R-HSA-975189)
IRAK1 [endosome membrane]
(R-HSA-975127)
p-S,T-IRAK1 [cytosol]
(R-HSA-3149574)
0.499
2
UniProt:O94822 LTN1
1
LTN1 [cytosol]
(R-HSA-5688967)
0.499
2
UniProt:Q96A33 CCD47
0.499
2
UniProt:Q96N66 MBOAT7
1
MBOAT7 [endoplasmic reticulum membrane]
(R-HSA-1498778)
0.499
2
UniProt:Q96HR9-2 REEP6
0.488
2
UniProt:Q9Y342 PLLP
0.488
2
UniProt:O95214 LERL1
0.488
2
UniProt:Q13190 STX5
5
STX5 [endoplasmic reticulum membrane]
(R-HSA-5689474)
STX5 [Golgi membrane]
(R-HSA-6807771)
STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5688157)
STX5 [ER to Golgi transport vesicle membrane]
(R-HSA-5689838)
STX5 [cytosol]
(R-HSA-9613991)
0.488
2
UniProt:P43308 SSR2
1
SSR2 [endoplasmic reticulum membrane]
(R-HSA-265061)
0.482
4
UniProt:Q99IB8-PRO_0000045601
0.463
5
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