Reactome | K63polyUb-STING [cytoplasmic vesicle membrane]

K63polyUb-STING [cytoplasmic vesicle membrane]

Stable Identifier

R-HSA-3248021

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytoplasmic vesicle membrane

Synonyms

MITA, TMEM173, ERIS

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q86WV6 STING1

Gene Names

STING1, ERIS, MITA, TMEM173

Chain

chain:1-379

Reference Genes

BioGPS Gene:340061 STING1

CTD Gene:340061 STING1

dbSNP Gene:340061 STING1

ENSEMBL:ENSG00000184584 TMEM173

ENSEMBL:ENSG00000288243 STING1

HGNC:27962 STING1

KEGG Gene (Homo sapiens):340061 STING1

Monarch:340061 STING1

NCBI Gene:340061 STING1

OMIM:612374 STING1

UCSC:Q86WV6 STING1

Reference Transcript

RefSeq:NM_198282.3 STING1

Other Identifiers

0001410398

11727044_a_at

17000650

224916_at

224929_at

2877991

2877992

2877993

2877994

2877995

2877998

2878000

2878002

2878003

2878004

2878005

2878006

2878007

2878008

2878009

340061

65817_at

8114536

A_23_P61371

GE88570

GO:0000045

GO:0000166

GO:0000421

GO:0002218

GO:0002230

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005741

GO:0005768

GO:0005773

GO:0005776

GO:0005777

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0005886

GO:0006810

GO:0006914

GO:0006950

GO:0008134

GO:0008150

GO:0009056

GO:0009058

GO:0010468

GO:0016020

GO:0016021

GO:0016032

GO:0016192

GO:0016239

GO:0019899

GO:0019901

GO:0022607

GO:0030176

GO:0030659

GO:0030667

GO:0031323

GO:0031410

GO:0031625

GO:0032092

GO:0032479

GO:0032481

GO:0032608

GO:0033116

GO:0034641

GO:0035438

GO:0035458

GO:0042802

GO:0042803

GO:0043167

GO:0043226

GO:0043312

GO:0044403

GO:0045087

GO:0045944

GO:0048471

GO:0050727

GO:0051091

GO:0051259

GO:0051607

GO:0061507

GO:0061709

GO:0065003

GO:0071360

GO:0071407

GO:1990701

Hs.86347.1.A1_3p_at

Hs.86347.1.A2_3p_at

ILMN_1761447

ILMN_2145116

PH_hs_0033001

TC05001845.hg

Participant Of

hasComponent

STING:STING [cytoplasmic vesicle membrane]

Other forms of this molecule

TMEM173 [plasma membrane]

TMEM173 [secretory granule membrane]

K63polyUb-STING [endoplasmic reticulum membrane]

TMEM173 [endoplasmic reticulum membrane]

Inferred To

Sting1 [cytoplasmic vesicle membrane] (Mus musculus)

Sting1 [cytoplasmic vesicle membrane] (Rattus norvegicus)

STING1 [cytoplasmic vesicle membrane] (Bos taurus)

STING1 [cytoplasmic vesicle membrane] (Canis familiaris)

sting1 [cytoplasmic vesicle membrane] (Danio rerio)

sting1 [cytoplasmic vesicle membrane] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at 150

Coordinate

150

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_938023.1

OpenTargets

ENSG00000184584

GeneCards

Q86WV6

HPA

ENSG00000184584-TMEM173

Ensembl

ENST00000672102, ENSP00000500823, ENST00000672865, ENSG00000184584, ENSP00000499166, ENSP00000498596, ENST00000652271, ENST00000330794, ENSP00000500793, ENST00000651699, ENST00000672096, ENSP00000331288, ENSG00000288243, ENSP00000500685

PRO

Q86WV6

Orphanet

23359

PDB

5JEJ, 6DNK, 6DXG, 6MX0, 6MX3, 6DXL, 4LOI, 4F5Y, 4EMU, 4KSY, 6O8B, 4QXQ, 4EMT, 4EF5, 4F5W, 4F9G, 4LOH, 6RM0, 6O8C, 4QXP, 6NT5, 4EF4, 4F9E, 6S26, 6MXE, 4QXO, 4QXR, 6S27, 5BQX, 6S86, 4F5E, 6CFF, 4F5D, 6CY7

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q86WV6 STING1	5	TMEM173 [secretory granule membrane] (R-HSA-6804798) TMEM173 [plasma membrane] (R-HSA-6804815) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) TMEM173 [endoplasmic reticulum membrane] (R-HSA-1834940)	0.961	14
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-S172-TBK1 [cytosol] (R-HSA-450290) p-TBK1 [cytosol] (R-HSA-9008705) TBK1 [cytosol] (R-HSA-166267)	0.899	9
UniProt:Q7Z434 MAVS	2	K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463) MAVS [mitochondrial outer membrane] (R-HSA-913730)	0.839	9
UniProt:Q7Z434-1 MAVS			0.78	7
UniProt:P42226 STAT6	6	p-S407,Y641-STAT6 [nucleoplasm] (R-HSA-3261241) p-S407-STAT6 [cytosol] (R-HSA-3249369) p-S407,Y641-STAT6 [cytosol] (R-HSA-3249376) STAT6 [cytosol] (R-HSA-629625) p-Y641-STAT6 [nucleoplasm] (R-HSA-6786279) p-Y641-STAT6 [cytosol] (R-HSA-6786109)	0.631	12
UniProt:O15260 SURF4	5	SURF4 [transport vesicle] (R-HSA-6813919) SURF4 [Golgi membrane] (R-HSA-6813912) SURF4 [endoplasmic reticulum membrane] (R-HSA-6813914) SURF4 [plasma membrane] (R-HSA-6806264) SURF4 [azurophil granule membrane] (R-HSA-6799361)	0.623	3
ChEBI:75947 CG(2'5')			0.558	2
UniProt:P09914 IFIT1	1	IFIT1 [cytosol] (R-HSA-937341)	0.558	3
ChEBI:75948 CG(2'5')			0.558	2
UniProt:P09913 IFIT2	1	IFIT2 [cytosol] (R-HSA-1015674)	0.558	3
UniProt:Q9NZ01 TECR	1	TECR [endoplasmic reticulum membrane] (R-HSA-548663)	0.556	3
UniProt:Q9NV29 TM100			0.556	3
UniProt:B2RUZ4 SMIM1			0.556	3
UniProt:Q96HR9-2 REEP6			0.556	3
UniProt:Q9Y342 PLLP			0.556	3
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:Q13190 STX5	5	STX5 [endoplasmic reticulum membrane] (R-HSA-5689474) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [cytosol] (R-HSA-9613991)	0.556	3
UniProt:O95214 LERL1			0.556	3
UniProt:Q9BWQ6 YIPF2			0.556	3
UniProt:P27958-PRO_0000037575			0.543	5
UniProt:Q16666 IFI16	1	IFI16 [cytosol] (R-HSA-1834934)	0.524	2
UniProt:O95786-1 DDX58			0.524	2
UniProt:P46977 STT3A	1	STT3A [endoplasmic reticulum membrane] (R-HSA-265023)	0.499	2
UniProt:P39656 DDOST	3	DDOST [plasma membrane] (R-HSA-879386) DDOST [azurophil granule membrane] (R-HSA-6799145) DDOST [endoplasmic reticulum membrane] (R-HSA-264963)	0.499	2
UniProt:O94822 LTN1	1	LTN1 [cytosol] (R-HSA-5688967)	0.499	2
UniProt:Q96A33 CCD47			0.499	2
UniProt:O95470 SGPL1	1	PXLP-SGPL1 [endoplasmic reticulum membrane] (R-HSA-428661)	0.499	2
UniProt:Q96N66 MBOAT7	1	MBOAT7 [endoplasmic reticulum membrane] (R-HSA-1498778)	0.499	2
UniProt:P51617 IRAK1	14	p-T209-IRAK1 [endosome membrane] (R-HSA-975189) K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) IRAK1 [endosome membrane] (R-HSA-975127) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) p-S,T-IRAK1 [cytosol] (R-HSA-3149574) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) IRAK1 [plasma membrane] (R-HSA-937045) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) IRAK1 [cytosol] (R-HSA-446639) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682)	0.499	2
UniProt:P43308 SSR2	1	SSR2 [endoplasmic reticulum membrane] (R-HSA-265061)	0.482	4
UniProt:P0C6X5-PRO_0000283876 REP			0.463	4
UniProt:Q99IB8-PRO_0000045601			0.463	5
UniProt:P0DTD2 9b	1	9b [cytosol] (R-COV-9694649)	0.463	2

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