Reactome | p-S407-STAT6 [cytosol]

p-S407-STAT6 [cytosol]

Stable Identifier

R-HSA-3249369

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Signal transducer and activator of transcription 6, STAT6_HUMAN

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External Reference Information

External Reference

UniProt:P42226 STAT6

Gene Names

STAT6

Chain

initiator methionine:1, chain:2-847

Reference Genes

BioGPS Gene:6778 STAT6

COSMIC (genes):STAT6 STAT6

CTD Gene:6778 STAT6

dbSNP Gene:6778 STAT6

ENSEMBL:ENSG00000166888 STAT6

HGNC:11368 STAT6

KEGG Gene (Homo sapiens):6778 STAT6

Monarch:6778 STAT6

NCBI Gene:6778 STAT6

OMIM:601512 STAT6

UCSC:P42226 STAT6

Reference Transcript

Other Identifiers

0006180441

11742723_a_at

11742724_x_at

11746850_a_at

11753889_a_at

16766420

201331_s_at

201332_s_at

3458338

3458339

3458340

3458341

3458342

3458343

3458344

3458345

3458347

3458348

3458350

3458352

3458353

3458354

3458356

3458357

3458360

3458361

3458362

3458363

3458365

3458366

3458367

3458368

3458369

3458370

3458371

3458372

3458375

41222_at

6778

7964360

845_at

A_23_P47879

GE79254

GO:0000122

GO:0000228

GO:0000790

GO:0000977

GO:0000978

GO:0000981

GO:0001228

GO:0002296

GO:0002376

GO:0002829

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006259

GO:0006355

GO:0006357

GO:0006950

GO:0006952

GO:0007165

GO:0007259

GO:0008150

GO:0008283

GO:0009058

GO:0019221

GO:0019899

GO:0019903

GO:0030154

GO:0032481

GO:0033598

GO:0034097

GO:0034641

GO:0035771

GO:0042127

GO:0042592

GO:0042802

GO:0043226

GO:0043434

GO:0043565

GO:0045121

GO:0045944

GO:0048295

GO:0048856

GO:0060397

GO:0060443

GO:0070301

GO:0120162

GO:1902170

ILMN_1763198

PH_hs_0036005

TC12001620.hg

TC12002913.hg

U16031_at

g13436385_3p_s_at

g4507258_3p_s_at

Participant Of

output

TBK1 phosphorylates STAT6 at Ser407

input

p-S407-STAT6 is phosphorylated at Tyr641

Other forms of this molecule

p-S407,Y641-STAT6 [nucleoplasm]

p-S407,Y641-STAT6 [cytosol]

STAT6 [cytosol]

p-Y641-STAT6 [nucleoplasm]

p-Y641-STAT6 [cytosol]

Inferred To

phospho-dstD [cytosol] (Dictyostelium discoideum)

phospho-STAT6 [cytosol] (Bos taurus)

phospho-STAT6 [cytosol] (Canis familiaris)

phospho-STAT6 [cytosol] (Sus scrofa)

phospho-sta-2 [cytosol] (Caenorhabditis elegans)

phospho-sta-1 [cytosol] (Caenorhabditis elegans)

Homologues of p-S407-STAT6 [cytosol] (Caenorhabditis elegans)

Homologues of p-S407-STAT6 [cytosol] (Danio rerio)

Homologues of p-S407-STAT6 [cytosol] (Dictyostelium discoideum)

phospho-stat5b [cytosol] (Danio rerio)

phospho-dstB [cytosol] (Dictyostelium discoideum)

phospho-dstC [cytosol] (Dictyostelium discoideum)

phospho-stat6 [cytosol] (Danio rerio)

phospho-stat5a [cytosol] (Danio rerio)

phospho-Stat92E [cytosol] (Drosophila melanogaster)

phospho-dstA [cytosol] (Dictyostelium discoideum)

phospho-myo19 [cytosol] (Xenopus tropicalis)

phospho-Stat6 [cytosol] (Mus musculus)

phospho-Stat6 [cytosol] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-serine at 407

Coordinate

407

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001171550.1, NP_003144.3, NP_001171549.1, XP_006719638.1, NP_001171551.1

OpenTargets

ENSG00000166888

GeneCards

P42226

HPA

ENSG00000166888-STAT6

ZINC - Substances

STAT6_HUMAN

Ensembl

ENSG00000166888, ENSP00000300134, ENSP00000444530, ENSP00000451742, ENST00000543873, ENSP00000445409, ENST00000454075, ENSP00000438451, ENST00000300134, ENST00000537215, ENST00000538913, ENST00000556155, ENSP00000401486

ZINC target

P42226

PRO

P42226

ZINC - Predictions - Purchasable

STAT6_HUMAN

Orphanet

21864

PDB

5NWX, 1OJ5, 4Y5U, 4Y5W, 5D39, 5NWM

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24394 IL4R	2	IL4R [plasma membrane] (R-HSA-449670) p-Y-IL4R [plasma membrane] (R-HSA-6786087)	0.643	4
UniProt:Q86WV6 STING1	5	K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) TMEM173 [endoplasmic reticulum membrane] (R-HSA-1834940) TMEM173 [plasma membrane] (R-HSA-6804815) TMEM173 [secretory granule membrane] (R-HSA-6804798)	0.631	12
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-S172-TBK1 [endosome membrane] (R-HSA-450290) p-TBK1 [cytosol] (R-HSA-9008705) TBK1 [cytosol] (R-HSA-166267)	0.577	7
UniProt:P42226 STAT6	6	p-S407,Y641-STAT6 [cytosol] (R-HSA-3249376) p-S407,Y641-STAT6 [nucleoplasm] (R-HSA-3261241) p-S407-STAT6 [cytosol] (R-HSA-3249369) STAT6 [cytosol] (R-HSA-629625) p-Y641-STAT6 [nucleoplasm] (R-HSA-6786279) p-Y641-STAT6 [cytosol] (R-HSA-6786109)	0.524	2
UniProt:Q7Z434 MAVS	2	K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463) MAVS [mitochondrial outer membrane] (R-HSA-913730)	0.462	3

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