Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-S407-STAT6 [cytosol]
Stable Identifier
R-HSA-3249369
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Signal transducer and activator of transcription 6, STAT6_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Cytosolic sensors of pathogen-associated DNA (Homo sapiens)
STING mediated induction of host immune responses (Homo sapiens)
STAT6-mediated induction of chemokines (Homo sapiens)
TBK1 phosphorylates STAT6 at Ser407 (Homo sapiens)
p-S407-STAT6 [cytosol] (Homo sapiens)
p-S407-STAT6 is phosphorylated at Tyr641 (Homo sapiens)
p-S407-STAT6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P42226 STAT6
Gene Names
STAT6
Chain
initiator methionine:1, chain:2-847
Reference Genes
BioGPS Gene:6778 STAT6
COSMIC (genes):STAT6 STAT6
CTD Gene:6778 STAT6
dbSNP Gene:6778 STAT6
ENSEMBL:ENSG00000166888 STAT6
HGNC:11368 STAT6
KEGG Gene (Homo sapiens):6778 STAT6
Monarch:6778 STAT6
NCBI Gene:6778 STAT6
OMIM:601512 STAT6
UCSC:P42226 STAT6
Reference Transcript
RefSeq:NM_003153.4 STAT6
RefSeq:NM_001178079.1 STAT6
RefSeq:XM_006719575.2 STAT6
RefSeq:NM_001178078.1 STAT6
RefSeq:NM_001178080.1 STAT6
Other Identifiers
0006180441
11742723_a_at
11742724_x_at
11746850_a_at
11753889_a_at
16766420
201331_s_at
201332_s_at
3458338
3458339
3458340
3458341
3458342
3458343
3458344
3458345
3458347
3458348
3458350
3458352
3458353
3458354
3458356
3458357
3458360
3458361
3458362
3458363
3458365
3458366
3458367
3458368
3458369
3458370
3458371
3458372
3458375
41222_at
6778
7964360
845_at
A_23_P47879
GE79254
GO:0000122
GO:0000228
GO:0000790
GO:0000977
GO:0000978
GO:0000981
GO:0001228
GO:0002296
GO:0002376
GO:0002829
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006259
GO:0006355
GO:0006357
GO:0006950
GO:0006952
GO:0007165
GO:0007259
GO:0008150
GO:0008283
GO:0009058
GO:0019221
GO:0019899
GO:0019903
GO:0030154
GO:0032481
GO:0033598
GO:0034097
GO:0034641
GO:0035771
GO:0042127
GO:0042592
GO:0042802
GO:0043226
GO:0043434
GO:0043565
GO:0045121
GO:0045944
GO:0048295
GO:0048856
GO:0060397
GO:0060443
GO:0070301
GO:0120162
GO:1902170
ILMN_1763198
PH_hs_0036005
TC12001620.hg
TC12002913.hg
U16031_at
g13436385_3p_s_at
g4507258_3p_s_at
Participant Of
output
TBK1 phosphorylates STAT6 at Ser407
input
p-S407-STAT6 is phosphorylated at Tyr641
Other forms of this molecule
p-S407,Y641-STAT6 [nucleoplasm]
p-S407,Y641-STAT6 [cytosol]
STAT6 [cytosol]
p-Y641-STAT6 [nucleoplasm]
p-Y641-STAT6 [cytosol]
Inferred To
phospho-dstD [cytosol] (Dictyostelium discoideum)
phospho-STAT6 [cytosol] (Bos taurus)
phospho-STAT6 [cytosol] (Canis familiaris)
phospho-STAT6 [cytosol] (Sus scrofa)
phospho-sta-2 [cytosol] (Caenorhabditis elegans)
phospho-sta-1 [cytosol] (Caenorhabditis elegans)
Homologues of p-S407-STAT6 [cytosol] (Caenorhabditis elegans)
Homologues of p-S407-STAT6 [cytosol] (Danio rerio)
Homologues of p-S407-STAT6 [cytosol] (Dictyostelium discoideum)
phospho-stat5b [cytosol] (Danio rerio)
phospho-dstB [cytosol] (Dictyostelium discoideum)
phospho-dstC [cytosol] (Dictyostelium discoideum)
phospho-stat6 [cytosol] (Danio rerio)
phospho-stat5a [cytosol] (Danio rerio)
phospho-Stat92E [cytosol] (Drosophila melanogaster)
phospho-dstA [cytosol] (Dictyostelium discoideum)
phospho-myo19 [cytosol] (Xenopus tropicalis)
phospho-Stat6 [cytosol] (Mus musculus)
phospho-Stat6 [cytosol] (Rattus norvegicus)
Modified Residues
Name
O-phospho-L-serine at 407
Coordinate
407
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001171549.1
,
NP_003144.3
,
NP_001171550.1
,
NP_001171551.1
,
XP_006719638.1
OpenTargets
ENSG00000166888
ZINC - Substances
STAT6_HUMAN
GeneCards
P42226
HPA
ENSG00000166888-STAT6
ZINC target
P42226
Ensembl
ENSP00000451742
,
ENSP00000445409
,
ENST00000300134
,
ENSP00000438451
,
ENST00000543873
,
ENST00000454075
,
ENST00000538913
,
ENSP00000300134
,
ENST00000537215
,
ENSG00000166888
,
ENSP00000444530
,
ENST00000556155
,
ENSP00000401486
PRO
P42226
ZINC - Predictions - Purchasable
STAT6_HUMAN
Orphanet
21864
PDB
4Y5U
,
1OJ5
,
5NWX
,
5NWM
,
4Y5W
,
5D39
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P24394 IL4R
2
IL4R [plasma membrane]
(R-HSA-449670)
p-Y-IL4R [plasma membrane]
(R-HSA-6786087)
0.643
4
UniProt:Q86WV6 STING1
5
TMEM173 [secretory granule membrane]
(R-HSA-6804798)
TMEM173 [plasma membrane]
(R-HSA-6804815)
K63polyUb-STING [endoplasmic reticulum membrane]
(R-HSA-3134805)
K63polyUb-STING [cytoplasmic vesicle membrane]
(R-HSA-3248021)
TMEM173 [endoplasmic reticulum membrane]
(R-HSA-1834940)
0.631
12
UniProt:Q9UHD2 TBK1
5
p-S172-TBK1 [cytosol]
(R-HSA-168379)
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
p-S172-TBK1 [cytosol]
(R-HSA-450290)
p-TBK1 [cytosol]
(R-HSA-9008705)
TBK1 [cytosol]
(R-HSA-166267)
0.577
7
UniProt:P42226 STAT6
6
p-S407,Y641-STAT6 [nucleoplasm]
(R-HSA-3261241)
p-S407-STAT6 [cytosol]
(R-HSA-3249369)
p-S407,Y641-STAT6 [cytosol]
(R-HSA-3249376)
STAT6 [cytosol]
(R-HSA-629625)
p-Y641-STAT6 [nucleoplasm]
(R-HSA-6786279)
p-Y641-STAT6 [cytosol]
(R-HSA-6786109)
0.524
2
UniProt:Q7Z434 MAVS
2
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
0.462
3
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text