Reactome | p-S407-STAT6 [cytosol]

p-S407-STAT6 [cytosol]

Stable Identifier

R-HSA-3249369

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Signal transducer and activator of transcription 6, STAT6_HUMAN

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External Reference Information

External Reference

UniProt:P42226 STAT6

Gene Names

STAT6

Chain

initiator methionine:1, chain:2-847

Reference Genes

BioGPS Gene:6778 STAT6

COSMIC (genes):STAT6 STAT6

CTD Gene:6778 STAT6

dbSNP Gene:6778 STAT6

ENSEMBL:ENSG00000166888 STAT6

HGNC:11368 STAT6

KEGG Gene (Homo sapiens):6778 STAT6

Monarch:6778 STAT6

NCBI Gene:6778 STAT6

OMIM:601512 STAT6

UCSC:P42226 STAT6

Reference Transcript

Other Identifiers

0006180441

11742723_a_at

11742724_x_at

11746850_a_at

11753889_a_at

16766420

1861

1OJ5

201331_s_at

201332_s_at

3458338

3458339

3458340

3458341

3458342

3458343

3458344

3458345

3458347

3458348

3458350

3458352

3458353

3458354

3458356

3458357

3458360

3458361

3458362

3458363

3458365

3458366

3458367

3458368

3458369

3458370

3458371

3458372

3458375

41222_at

4Y5U

4Y5W

5D39

5NWM

5NWX

6778

7964360

845_at

A0A1W2PNW1

A0A494C0T4

A_23_P47879

AAA57193

AAC67525

AAH75852

AAL06595

AB103089

AC023237

AF067572

AF067573

AF067575

AF417842

AK290431

AK316142

BAD89432

BAF83120

BAH14513

BC075852

CCDS53804

CCDS8931

ENSG00000166888

ENSP00000300134

ENSP00000401486

ENSP00000438451

ENSP00000444530

ENSP00000445409

ENSP00000451742

ENSP00000451909

ENST00000300134

ENST00000300134.7

ENST00000454075

ENST00000454075.7

ENST00000537215

ENST00000537215.6

ENST00000538913

ENST00000538913.6

ENST00000543873

ENST00000543873.6

ENST00000554764

ENST00000556155

ENST00000556155.5

EntrezGene:6778

EntrezGene:STAT6

g13436385_3p_s_at

G3V2H4

G3V2L2

G3V2M3

G3V370

G3V568

G3V5I8

G3V5K5

g4507258_3p_s_at

GE79254

GO:0000122

GO:0000228

GO:0000790

GO:0000977

GO:0000978

GO:0000981

GO:0001228

GO:0002296

GO:0002376

GO:0002829

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006259

GO:0006355

GO:0006357

GO:0006950

GO:0006952

GO:0007165

GO:0007259

GO:0008150

GO:0008283

GO:0009058

GO:0019221

GO:0019899

GO:0019903

GO:0030154

GO:0031965

GO:0032481

GO:0033598

GO:0034097

GO:0034641

GO:0035771

GO:0042127

GO:0042592

GO:0042802

GO:0043226

GO:0043434

GO:0043565

GO:0045121

GO:0045944

GO:0048295

GO:0048856

GO:0060397

GO:0060443

GO:0070301

GO:0120162

GO:1902170

H0YIY2

H0YJH6

HGNC:11368

HPA001861

ILMN_1763198

IPR000980

IPR001217

IPR008967

IPR012345

IPR013799

IPR013800

IPR013801

IPR015988

IPR028187

IPR035857

IPR036535

IPR036860

LRG_1369

LRG_1369t1

MIM:601512

NM_001178078

NM_001178079

NM_001178080

NM_001178081

NM_003153

NP_001171549

NP_001171550

NP_001171551

NP_001171552

NP_003144

PF00017

PF01017

PF02864

PF02865

PF14596

PH_hs_0036005

Q5FBW6

SM00252

SM00964

STAT6

STAT6-201

STAT6-202

STAT6-203

STAT6-204

STAT6-205

STAT6-219

TC12001620.hg

TC12002913.hg

U16031

U16031_at

UPI00000473FE

UPI0000153B81

XM_011538708

XP_011537010

Participant Of

output

TBK1 phosphorylates STAT6 at Ser407

input

p-S407-STAT6 is phosphorylated at Tyr641

Other forms of this molecule

STAT6 [cytosol]

p-Y641-STAT6 [cytosol]

p-Y641-STAT6 [nucleoplasm]

p-S407,Y641-STAT6 [cytosol]

p-S407,Y641-STAT6 [nucleoplasm]

Inferred To

Homologues of p-S407-STAT6 [cytosol] (Caenorhabditis elegans)

Homologues of p-S407-STAT6 [cytosol] (Danio rerio)

Homologues of p-S407-STAT6 [cytosol] (Dictyostelium discoideum)

phospho-p-S407-STAT6 [cytosol] (Bos taurus)

phospho-p-S407-STAT6 [cytosol] (Caenorhabditis elegans)

phospho-p-S407-STAT6 [cytosol] (Canis familiaris)

phospho-p-S407-STAT6 [cytosol] (Danio rerio)

phospho-p-S407-STAT6 [cytosol] (Dictyostelium discoideum)

phospho-p-S407-STAT6 [cytosol] (Drosophila melanogaster)

phospho-p-S407-STAT6 [cytosol] (Gallus gallus)

phospho-p-S407-STAT6 [cytosol] (Mus musculus)

phospho-p-S407-STAT6 [cytosol] (Rattus norvegicus)

phospho-p-S407-STAT6 [cytosol] (Sus scrofa)

phospho-p-S407-STAT6 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 407

Coordinate

407

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_003144.3, NP_001171549.1, NP_001171550.1, NP_001171551.1, XP_006719638.1

OpenTargets

ENSG00000166888

GeneCards

P42226

ZINC - Substances

STAT6_HUMAN

ZINC target

P42226

PRO

P42226

ZINC - Predictions - Purchasable

STAT6_HUMAN

Orphanet

21864

PDB

5D39, 4Y5W, 4Y5U, 5NWX, 1OJ5, 5NWM

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P24394 IL4R	2	p-Y-IL4R [plasma membrane] (R-HSA-6786087) IL4R [plasma membrane] (R-HSA-449670)	0.643	4
UniProt:Q86WV6 TMEM173	5	TMEM173 [secretory granule membrane] (R-HSA-6804798) TMEM173 [plasma membrane] (R-HSA-6804815) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) TMEM173 [endoplasmic reticulum membrane] (R-HSA-1834940)	0.631	12
UniProt:Q9UHD2 TBK1	6	p-S172-TBK1 [endosome membrane] (R-HSA-450290) p-S172-TBK1 [plasma membrane] (R-HSA-936983) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) TBK1 [cytosol] (R-HSA-166267) p-S172-TBK1 [cytosol] (R-HSA-168379)	0.577	7
UniProt:P42226 STAT6	6	p-Y641-STAT6 [cytosol] (R-HSA-6786109) STAT6 [cytosol] (R-HSA-629625) p-Y641-STAT6 [nucleoplasm] (R-HSA-6786279) p-S407,Y641-STAT6 [cytosol] (R-HSA-3249376) p-S407,Y641-STAT6 [nucleoplasm] (R-HSA-3261241) p-S407-STAT6 [cytosol] (R-HSA-3249369)	0.524	2
UniProt:Q7Z434 MAVS	2	K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463) MAVS [mitochondrial outer membrane] (R-HSA-913730)	0.462	3