Reactome: A Curated Pathway Database

SLC37A1, SLC37A2 exchange G6P for Pi across the endoplasmic reticulum membrane

Stable Identifier
R-HSA-3257122
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
alpha-D-glucose 6-phosphate (cytosol) + orthophosphate (ER lumen) => alpha-D-glucose 6-phosphate (ER lumen) + orthophosphate (cytosol) (SLC37A1 or SLC37A2)
Locations in the PathwayBrowser
Summation

The SLC37A1 and SLC37A2 transport proteins mediate the exchange of glucose-6-phosphate and orthophosphate across lipid bilayer membranes in vitro, and both proteins are located in the endoplasmic reticulum membrane. Their physiological function, however, is unknown (Pan et al. 2011; Chou et al. 2013).

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
glucose 6-phosphate:inorganic phosphate antiporter activity of SLC37A1,2 [endoplasmic reticulum membrane] SLC37A1,2 [endoplasmic reticulum membrane] glucose 6-phosphate:inorganic phosphate antiporter activity (0061513)
Orthologous Events