G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)

Stable Identifier
R-HSA-3262512
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC3 - ubiquitous)
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Glucose-6-phosphatase 3 (G6PC3) associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of glucose-6-phosphate to glucose and orthophosphate. This reaction is essentially irreversible (Guionie et al. 2003; Ghosh et al. 2004). In the body, this enzyme is ubiquitously expressed; mutations that inactivate it are associated with severe congenital neutropenia (but not with fasting hypoglycemia or lactic acidemia) (Boztug et al. 2009).

Literature References
PubMed ID Title Journal Year
12965222 Identification and characterisation of a new human glucose-6-phosphatase isoform

Guionie, O, Clottes, E, Stafford, K, Burchell, A

FEBS Lett 2003
19118303 A syndrome with congenital neutropenia and mutations in G6PC3

Boztug, K, Appaswamy, G, Ashikov, A, Schäffer, AA, Salzer, U, Diestelhorst, J, Germeshausen, M, Brandes, G, Lee-Gossler, J, Noyan, F, Gatzke, AK, Minkov, M, Greil, J, Kratz, C, Petropoulou, T, Pellier, I, Bellanné-Chantelot, C, Rezaei, N, Mönkemöller, K, Irani-Hakimeh, N, Bakker, H, Gerardy-Schahn, R, Zeidler, C, Grimbacher, B, Welte, K, Klein, C

N. Engl. J. Med. 2009
14718531 Histidine 167 is the phosphate acceptor in glucose-6-phosphatase-beta forming a phosphohistidine enzyme intermediate during catalysis

Ghosh, A, Shieh, JJ, Pan, CJ, Chou, JY

J. Biol. Chem. 2004
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
glucose-6-phosphatase activity of G6PC3 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Reviewed
Created