Reactome: A Curated Pathway Database

G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)

Stable Identifier
R-HSA-3262512
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC3 - ubiquitous)
Locations in the PathwayBrowser
Summation

Glucose-6-phosphatase 3 (G6PC3) associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of glucose-6-phosphate to glucose and orthophosphate. This reaction is essentially irreversible (Guionie et al. 2003; Ghosh et al. 2004). In the body, this enzyme is ubiquitously expressed; mutations that inactivate it are associated with severe congenital neutropenia (but not with fasting hypoglycemia or lactic acidemia) (Boztug et al. 2009).

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
glucose-6-phosphatase activity of G6PC3 [endoplasmic reticulum membrane] G6PC3 [endoplasmic reticulum membrane] glucose-6-phosphatase activity (0004346)
Orthologous Events