Reactome | Factor I cleaves iC3b

Factor I cleaves iC3b

Stable Identifier

R-HSA-3266557

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, extracellular region

ReviewStatus

5/5

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Factor I (CFI) cleaves iC3b into two molecules, C3c, which is released into solution, and C3dg, which remains attached to the membrane. This cleavage requires Complement receptor type 1 (CR1), which serves a cofactor for CFI (Medof et al. 1982). iC3b and C3dg can bind CR2 (CD21) to enhance B-cell immunity (Tuveson et al.1991, Sarrias et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
2971659	Identification of the C3b receptor-binding domain in third component of complement Lambris, JD, Becherer, JD	J. Biol. Chem.	1988
6607952	Physiologic inactivation of fluid phase C3b: isolation and structural analysis of C3c, C3d,g (alpha 2D), and C3g Harrison, RA, Davis, AE, Lachmann, PJ	J. Immunol.	1984
21788512	Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy de Córdoba, SR, Fernández, FJ, Round, A, Alcorlo, M, Martínez-Barricarte, R, Llorca, O, Harris, CL, Vega, MC, Rodríguez-Gallego, C	Proc. Natl. Acad. Sci. U.S.A.	2011