G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet)

Stable Identifier
R-HSA-3266566
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC2 - islet)
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Glucose-6-phosphatase 2 (G6PC2), associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of glucose-6-phosphate to glucose and orthophosphate. This reaction is essentially irreversible. In the body, this enzyme is islet cells of the pancreas (Petrolonis et al. 2004).

Literature References
PubMed ID Title Journal Year
14722102 Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP)

Petrolonis, AJ, Yang, Q, Tummino, PJ, Fish, SM, Prack, AE, Jain, S, Parsons, TF, Li, P, Dales, NA, Ge, L, Langston, SP, Schuller, AG, An, WF, Tartaglia, LA, Chen, H, Hong, SB

J Biol Chem 2004
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
glucose-6-phosphatase activity of G6PC2 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Reviewed
Created