G6PC2 hydrolyzes G6P to form Glc and Pi (islet)

Stable Identifier
R-HSA-3266566
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
alpha-D-Glucose 6-phosphate + H2O => alpha-D-Glucose + Orthophosphate (G6PC2 - islet)
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
G6PC2 (Glucose-6-phosphatase 2), associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of glucose-6-phosphate (G6P) to glucose (Glc) and orthophosphate (Pi). This reaction is essentially irreversible. This enzyme is expressed in islet cells of the pancreas (Petrolonis et al. 2004).
Literature References
PubMed ID Title Journal Year
14722102 Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP)

Jain, S, Prack, AE, An, WF, Fish, SM, Tartaglia, LA, Tummino, PJ, Ge, L, Schuller, AG, Langston, SP, Petrolonis, AJ, Yang, Q, Dales, NA, Hong, SB, Parsons, TF, Li, P, Chen, H

J Biol Chem 2004
Participants
Participates
Catalyst Activity

glucose-6-phosphatase activity of G6PC2 [endoplasmic reticulum membrane]

Orthologous Events
Cross References
Rhea
Reviewed
Created
Cite Us!