Reactome | CAPNS1 [cytosol]

CAPNS1 [cytosol]

Stable Identifier

R-HSA-3288229

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Calpain small subunit 1, CPNS1_HUMAN

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to mechanical stimuli (Homo sapiens)
  - Response of endothelial cells to shear stress (Homo sapiens)
    - High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells (Homo sapiens)
      - Ca2+ activates Calpain2 (m-Calpain) (Homo sapiens)
        
        Calpain2 [cytosol] (Homo sapiens)
        
        CAPNS [cytosol] (Homo sapiens)
        
        CAPNS1 [cytosol] (Homo sapiens)
    - Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells (Homo sapiens)
      - Ca2+ activates Calpain2 (m-Calpain) (Homo sapiens)
        
        Calpain2 [cytosol] (Homo sapiens)
        
        CAPNS [cytosol] (Homo sapiens)
        
        CAPNS1 [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Diseases of programmed cell death (Homo sapiens)
  - Defective Intrinsic Pathway for Apoptosis (Homo sapiens)
    - Neurodegenerative Diseases (Homo sapiens)
      - Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models (Homo sapiens)
        
        Calpain activation (Homo sapiens)
        
        Calpain1,Calpain2 [cytosol] (Homo sapiens)
        
        Calpain1 [cytosol] (Homo sapiens)
        
        CAPNS [cytosol] (Homo sapiens)
        
        CAPNS1 [cytosol] (Homo sapiens)
        
        Calpain2 [cytosol] (Homo sapiens)
        
        CAPNS [cytosol] (Homo sapiens)
        
        CAPNS1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P04632 CAPNS1

Gene Names

CAPNS1, CAPN4, CAPNS

Chain

chain:1-268

Reference Genes

BioGPS Gene:826 CAPNS1

COSMIC (genes):CAPNS1 CAPNS1

CTD Gene:826 CAPNS1

dbSNP Gene:826 CAPNS1

ENSEMBL:ENSG00000126247 CAPNS1

HGNC:1481 CAPNS1

KEGG:hsa:826 CAPNS1

Monarch:826 CAPNS1

NCBI Gene:826 CAPNS1

OMIM:114170 CAPNS1

UCSC:P04632 CAPNS1

Reference Transcript

Other Identifiers

11758205_x_at

11758295_at

16652937

16652939

16652941

16652943

16652945

16652947

16652949

16652951

16652953

16652961

16652963

16652965

16652967

16652973

16652975

16652977

16652979

16652985

16861380

18671221

18671222

18671223

18671224

18671225

18671226

18671227

18671228

18671229

200001_PM_at

200001_at

36138_at

3831169

3831170

3831171

3831172

3831173

3831174

3831176

3831177

3831178

3831179

3831181

3831182

3831183

3831184

3831185

3831186

3831187

3831190

3831191

3831192

3831193

3831194

3831195

3831196

3831197

3831199

3831205

3831207

3831209

3831217

3831219

3831221

3831223

3831225

3831227

3831229

7892989

7893100

7893173

7893327

7893539

7893544

7893740

7893764

7893828

7893995

7894512

7894523

7894542

7894696

7894761

7894880

7895041

7895239

7895873

7895903

7895928

7896030

7896258

7896355

7896370

7896533

8028172

826

A_14_P121166

A_23_P67648

GE62015

GO:0003824

GO:0004198

GO:0005509

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0006508

GO:0008284

GO:0016020

GO:0016241

GO:0016787

GO:0043226

GO:0046872

GO:0070062

GO:0110158

GO:0140096

HMNXSV003018689

HMNXSV003044471

ILMN_1655418

ILMN_2393254

PH_hs_0024468

PH_hs_0033087

TC19000496.hg

X04106_at

g4502564_3p_s_at

Participates

as a component of

Calpain1 [cytosol] (Homo sapiens)

as a member of

CAPNS [cytosol] (Homo sapiens)

Other forms of this molecule

CAPNS1 [plasma membrane]

Inferred To

capns1a [cytosol] (Danio rerio)

capns2 [cytosol] (Xenopus tropicalis)

capns1b [cytosol] (Danio rerio)

CAPNS1 [cytosol] (Bos taurus)

CAPNS1 [cytosol] (Canis familiaris)

CAPNS1 [cytosol] (Mus musculus)

CAPNS1 [cytosol] (Rattus norvegicus)

CAPNS1 [cytosol] (Sus scrofa)

Homologues of CAPNS1 [cytosol] (Danio rerio)

Homologues of CAPNS1 [cytosol] (Sus scrofa)

Cross References

ENSEMBL

ENST00000246533, ENST00000588815, ENSP00000464849, ENSP00000246533

OpenTargets

ENSG00000126247

HPA

ENSG00000126247-CAPNS1

PRO

P04632

Pharos - Targets

P04632

GlyGen

P04632

HMDB Protein

HMDBP07628

PDB

4WQ2, 4PHM, 5D69, 4PHK, 6QLB, 4WQ3, 4PHJ, 1KFU, 1KFX

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.643	5
UniProt:P01375 TNF	5	TNF(1-233) [plasma membrane] (R-HSA-66220) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375)	0.527	2
UniProt:P20936 RASA1	1	RASA1 [cytosol] (R-HSA-186833)	0.524	3