TRPM4,5 transport extracellular Na+ to cytosol

Stable Identifier
R-HSA-3295580
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Most members of the TRP channel family are permeable to Ca2+. Although TRPM4 and 5 can be activated by increased levels of intracellular Ca2+, they are impermeable to it. Instead, they are monovalent-selective with highest affinity for Na+ transport, of which leads to depolarization of the membrane (Launay et al. 2002, Prawitt et al. 2003). They play a central role in cardiomyocytes, neurons, endocrine pancreas cells, kidney epithelial cells and cochlea hair cells.

Literature References
PubMed ID Title Journal Year
14634208 TRPM5 is a transient Ca2+-activated cation channel responding to rapid changes in [Ca2+]i

Prawitt, D, Monteilh-Zoller, MK, Brixel, L, Spangenberg, C, Zabel, B, Fleig, A, Penner, R

Proc. Natl. Acad. Sci. U.S.A. 2003
12015988 TRPM4 is a Ca2+-activated nonselective cation channel mediating cell membrane depolarization

Launay, P, Fleig, A, Perraud, AL, Scharenberg, AM, Penner, R, Kinet, JP

Cell 2002
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
sodium channel activity of TRPM4,5 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed