Reactome | TAS2R60 [plasma membrane]

TAS2R60 [plasma membrane]

Stable Identifier

R-HSA-3299617

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Taste receptor type 2 member 60, T2R60_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R60 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R60 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R60 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R60 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R60 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R60 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - T2Rs bind bitter-tasting compounds (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R60 [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R60 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P59551 TAS2R60

Gene Names

TAS2R60

Chain

chain:1-318

Reference Genes

BioGPS Gene:338398 TAS2R60

COSMIC (genes):TAS2R60 TAS2R60

CTD Gene:338398 TAS2R60

dbSNP Gene:338398 TAS2R60

ENSEMBL:ENSG00000185899 TAS2R60

ENSEMBL_homo_sapiens_GENE:ENSG00000185899.1 TAS2R60

ENSEMBL_homo_sapiens_GENE:ENSG00000285341.1 TAS2R60

HGNC:20639 TAS2R60

KEGG Gene (Homo sapiens):338398 TAS2R60

Monarch:338398 TAS2R60

NCBI Gene:338398 TAS2R60

OMIM:613968 TAS2R60

UCSC:P59551 TAS2R60

Reference Transcript

RefSeq:NM_177437.1 TAS2R60

Other Identifiers

11734637_at

17052848

3029202

3029203

3029204

3029205

3029206

3029207

3029208

338398

8136930

A_14_P118907

A_23_P367013

GO:0004930

GO:0005886

GO:0007165

GO:0007186

GO:0016020

GO:0023052

GO:0050877

GO:0050896

GO:0050909

GO:0050913

GO:0060089

HMNXSV003026350

ILMN_1715923

PH_hs_0026262

TC07000937.hg

Participates

as a member of

TAS2Rs [plasma membrane] (Homo sapiens)

Inferred To

t2r14 [plasma membrane] (Xenopus tropicalis)

t2r2 [plasma membrane] (Xenopus tropicalis)

tas2r1a [plasma membrane] (Danio rerio)

TAS2R1b [plasma membrane] (Danio rerio)

t2r3 [plasma membrane] (Xenopus tropicalis)

TAS2R7 [plasma membrane] (Gallus gallus)

Homologues of TAS2R60 [plasma membrane] (Danio rerio)

Homologues of TAS2R60 [plasma membrane] (Gallus gallus)

Homologues of TAS2R60 [plasma membrane] (Xenopus tropicalis)

Tas2r135 [plasma membrane] (Mus musculus)

Tas2r135 [plasma membrane] (Rattus norvegicus)

TAS2R60 [plasma membrane] (Bos taurus)

TAS2R60 [plasma membrane] (Sus scrofa)

tas2r7 [plasma membrane] (Xenopus tropicalis)

TAS2R40 [plasma membrane] (Gallus gallus)

t2r15 [plasma membrane] (Xenopus tropicalis)

tas2r4 [plasma membrane] (Xenopus tropicalis)

LOC101747503 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_803186.1

Guide to Pharmacology - Targets

681

OpenTargets

ENSG00000185899

GeneCards

P59551

HPA

ENSG00000185899-TAS2R60

ZINC target

P59551

Ensembl

ENSG00000185899, ENSG00000285341, ENST00000642941, ENSP00000494922, ENSP00000327724, ENST00000332690

PRO

P59551

Pharos - Targets

P59551