Reactome | TAS2R8 [plasma membrane]

TAS2R8 [plasma membrane]

Stable Identifier

R-HSA-3299620

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Taste receptor type 2 member 8, TA2R8_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R8 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R8 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R8 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R8 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R8 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R8 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class C/3 (Metabotropic glutamate/pheromone receptors) (Homo sapiens)
      - T2Rs bind bitter-tasting compounds (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R8 [plasma membrane] (Homo sapiens)
        
        TAS2Rs:Bitter-tasting compounds [plasma membrane] (Homo sapiens)
        
        TAS2Rs [plasma membrane] (Homo sapiens)
        
        TAS2R8 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NYW2 TAS2R8

Gene Names

TAS2R8

Chain

chain:1-309

Reference Genes

BioGPS Gene:50836 TAS2R8

COSMIC (genes):TAS2R8 TAS2R8

CTD Gene:50836 TAS2R8

dbSNP Gene:50836 TAS2R8

ENSEMBL:ENSG00000121314 TAS2R8

ENSEMBL_homo_sapiens_GENE:ENSG00000121314.3 TAS2R8

ENSEMBL_homo_sapiens_GENE:ENSG00000272712.1 TAS2R8

ENSEMBL_homo_sapiens_GENE:ENSG00000277316.2 TAS2R8

HGNC:14915 TAS2R8

KEGG Gene (Homo sapiens):50836 TAS2R8

Monarch:50836 TAS2R8

NCBI Gene:50836 TAS2R8

OMIM:604794 TAS2R8

UCSC:Q9NYW2 TAS2R8

Reference Transcript

RefSeq:NM_023918.1 TAS2R8

Other Identifiers

11732972_at

16761457

221398_PM_at

221398_at

3444305

3444306

3444308

50836

7961243

ADDON002837.hg

A_23_P48022

GE499570

GO:0001580

GO:0004930

GO:0005515

GO:0005886

GO:0007165

GO:0007186

GO:0008527

GO:0016020

GO:0023052

GO:0033038

GO:0050877

GO:0050896

GO:0050909

GO:0060089

HMNXSV003013417

ILMN_1807159

ILMN_2107040

PH_hs_0014066

TC12001229.hg

TC12002760.hg

g12965173_3p_at

Participates

as a member of

as a component of

TAS2R8:ligand [plasma membrane] (Homo sapiens)

Inferred To

t2r14 [plasma membrane] (Xenopus tropicalis)

t2r2 [plasma membrane] (Xenopus tropicalis)

Homologues of TAS2R20 [plasma membrane] (Danio rerio)

Homologues of TAS2R20 [plasma membrane] (Gallus gallus)

Homologues of TAS2R20 [plasma membrane] (Xenopus tropicalis)

tas2r1a [plasma membrane] (Danio rerio)

TAS2R1b [plasma membrane] (Danio rerio)

t2r3 [plasma membrane] (Xenopus tropicalis)

TAS2R7 [plasma membrane] (Gallus gallus)

tas2r7 [plasma membrane] (Xenopus tropicalis)

TAS2R40 [plasma membrane] (Gallus gallus)

TAS2R8 [plasma membrane] (Bos taurus)

t2r15 [plasma membrane] (Xenopus tropicalis)

tas2r4 [plasma membrane] (Xenopus tropicalis)

LOC101747503 [plasma membrane] (Gallus gallus)

Cross References

RefSeq

NP_076407.1

Guide to Pharmacology - Targets

664

OpenTargets

ENSG00000121314

HPA

ENSG00000121314-TAS2R8

GeneCards

Q9NYW2

Ensembl

ENSG00000121314, ENSP00000240615, ENSP00000484163, ENSG00000272712, ENSP00000461158, ENST00000240615, ENST00000572823, ENST00000610444, ENSG00000277316

PRO

Q9NYW2

Pharos - Targets

Q9NYW2