SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)

Stable Identifier
R-HSA-3299691
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cu-Zn superoxide dismutase (SOD1), originally known as erythrocuprein, catalyzes the reaction of two molecules of superoxide (O2.-) to yield one molecule of hydrogen peroxide (H2O2) and one molecule of oxygen (O2) (McCord and Fridovich 1969 assayed both bovine and human Cu-Zn superoxide dismutase, the human sample provided by Carrico and Deutsch). Diffusion of hydrogen peroxide, the product of SOD1, across the cytosol is limited (Mishina et al. 2011)

Literature References
PubMed ID Title Journal Year
5389100 Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)

McCord, JM, Fridovich, I

J. Biol. Chem. 1969
20690882 Does cellular hydrogen peroxide diffuse or act locally?

Mishina, NM, Tyurin-Kuzmin, PA, Markvicheva, KN, Vorotnikov, AV, Tkachuk, VA, Laketa, V, Schultz, C, Lukyanov, S, Belousov, VV

Antioxid. Redox Signal. 2011
7021796 Purification of superoxide dismutases from human placenta using immunoadsorbent columns

Sugiura, M, Adachi, T, Inoue, H, Ito, Y, Hirano, K

J. Pharmacobio-dyn. 1981
3532102 High-level expression of enzymatically active human Cu/Zn superoxide dismutase in Escherichia coli

Hartman, JR, Geller, T, Yavin, Z, Bartfeld, D, Kanner, D, Aviv, H, Gorecki, M

Proc. Natl. Acad. Sci. U.S.A. 1986
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
superoxide dismutase activity of 2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed