SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)

Stable Identifier
R-HSA-3299691
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Cu-Zn superoxide dismutase (SOD1), originally known as erythrocuprein, catalyzes the reaction of two molecules of superoxide (O2.-) to yield one molecule of hydrogen peroxide (H2O2) and one molecule of oxygen (O2) (McCord and Fridovich 1969 assayed both bovine and human Cu-Zn superoxide dismutase, the human sample provided by Carrico and Deutsch). Diffusion of hydrogen peroxide, the product of SOD1, across the cytosol is limited (Mishina et al. 2011)

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
superoxide dismutase activity of 2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Cross References
Rhea