Reactome: A Curated Pathway Database

GSTK1 dimer transfers GS from GSH to CDNB

Stable Identifier
R-HSA-3301943
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Glutathione S-transferase Kappa isozyme (GSTK1) is widely expressed in human tissues and exists as a dimer in mitochondria and peroxisomes. It has high activity towards aryl halides such as the model substrate 1-chloro-2,4-dinitrobenzene (CDNB) to which it can conjugate with glutathionate (GS-) from glutathione (GSH) (Morel et al. 2004). Mouse, rat and human possess only one GST Kappa isozyme.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
glutathione transferase activity of GSTK1 dimer [mitochondrial matrix] GSTK1 dimer [mitochondrial matrix] glutathione transferase activity (0004364)
Orthologous Events
Cross References
Rhea