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GSTK1 dimer transfers GS from GSH to CDNB

Stable Identifier
R-HSA-3301943
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Glutathione S-transferase Kappa isozyme (GSTK1) is widely expressed in human tissues and exists as a dimer in mitochondria and peroxisomes. It has high activity towards aryl halides such as the model substrate 1-chloro-2,4-dinitrobenzene (CDNB) to which it can conjugate with glutathionate (GS-) from glutathione (GSH) (Morel et al. 2004). Mouse, rat and human possess only one GST Kappa isozyme.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutathione transferase activity of GSTK1 dimer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea