Reactome | BRPF3 [nucleoplasm]

BRPF3 [nucleoplasm]

Stable Identifier

R-HSA-3318471

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Bromodomain and PHD finger-containing protein 3

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Acetylation (Homo sapiens)
        
        AKT phosphorylates KAT6A (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF3 [nucleoplasm] (Homo sapiens)
        
        p-T369-KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF3 [nucleoplasm] (Homo sapiens)
        
        KAT6A acetylates TP53 (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF3 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF3 [nucleoplasm] (Homo sapiens)
        
        KAT6A and PML bind TP53 (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF3 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF3 [nucleoplasm] (Homo sapiens)
        
        MTA2-NuRD complex deacetylates TP53 (Homo sapiens)
        
        BRD7:Ac-K382,p-S15,S20-TP53:EP300, KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,K382,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF3 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53, BRD7:p-S15,S20-TP53:EP300 [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3):PML:Ac-K120,p-S15,S20-TP53 Tetramer [nucleoplasm] (Homo sapiens)
        
        KAT6A:ING5:MEAF6:BRPF1,(2,3) [nucleoplasm] (Homo sapiens)
        
        BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)
        
        BRPF3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9ULD4 BRPF3

Gene Names

BRPF3, KIAA1286

Chain

chain:1-1205

Reference Genes

BioGPS Gene:27154 Q9ULD42

COSMIC (genes):BRPF3 BRPF3

CTD Gene:27154 Q9ULD42

dbSNP Gene:27154 Q9ULD42

ENSEMBL:ENSG00000096070 BRPF3

HGNC:14256 Q9ULD42

KEGG:hsa:27154 Q9ULD42

Monarch:27154 Q9ULD42

NCBI Gene:27154 Q9ULD42

UCSC:Q9ULD4 Q9ULD42

Reference Transcript

Participates

as a candidate of

BRPF1, (BRPF2, 3) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

BRPF3 [extracellular region]

BRPF3 [cytosol]

Inferred To

lin-49 [nucleoplasm] (Caenorhabditis elegans)

nto1 [nucleoplasm] (Schizosaccharomyces pombe)

BRPF3 [nucleoplasm] (Bos taurus)

BRPF3 [nucleoplasm] (Canis familiaris)

BRPF3 [nucleoplasm] (Dictyostelium discoideum)

BRPF3 [nucleoplasm] (Drosophila melanogaster)

BRPF3 [nucleoplasm] (Gallus gallus)

BRPF3 [nucleoplasm] (Sus scrofa)

brpf3 [nucleoplasm] (Xenopus tropicalis)

Brpf3 [nucleoplasm] (Mus musculus)

Brpf3 [nucleoplasm] (Rattus norvegicus)

Cross References

Guide to Pharmacology - Targets

2731

ENSEMBL

ENST00000357641, ENST00000534694, ENSP00000350267, ENSG00000096070, ENST00000339717, ENSP00000434501, ENSP00000345419

OpenTargets

ENSG00000096070

GeneCards

BRPF3

HPA

ENSG00000096070-BRPF3

ZINC - Substances

BRPF3_HUMAN

ZINC target

Q9ULD4

PRO

Q9ULD4

Pharos - Targets

Q9ULD4

PDB

3PFS

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16236 NFE2L2	13	p-S40-NFE2L2 [nucleoplasm] (R-HSA-9715109) p-S,T-NFE2L2 [nucleoplasm] (R-HSA-9715110) p-S40-NFE2L2 [cytosol] (R-HSA-8932290) p-S,T-NFE2L2 [cytosol] (R-HSA-8932311) NFE2L2 [cytosol] (R-HSA-201566) p-S,T-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760033) p-S40-18 AcK-NFE2L2 [nucleoplasm] (R-HSA-9760018) ub-NFE2L2 [cytosol] (R-HSA-9758077) ub-p-S335, S338,T-NFE2L2 [nucleoplasm] (R-HSA-9762055) ub-p-S40, S335, S338- NFE2L2 [nucleoplasm] (R-HSA-9762058) p-S344, S347,T-NFE2L2 [nucleoplasm] (R-HSA-9762048) p-S40, S344, S347- NFE2L2 [nucleoplasm] (R-HSA-9762050) p-S,T,S558-NFE2L2 [nucleoplasm] (R-HSA-9795736)	0.508	3