NSL acetylates histone H4

Stable Identifier
R-HSA-3321805
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
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NSL acetylates histone H4
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KAT8 (MOF, MYST1) is a member of the MYST (Moz-Ybf2/Sas3-Sas2-Tip60) family of histone acetyltransferases (HATs). KAT8 is the catalytic component of the nine-subunit non-specific lethal (NSL) complex (Mendjan et al. 2006, Cai et al. 2010).

NSL acetylates histone H4 on lysines 17 (H4K16), 6 (H4K5) and 9 (H4K8) (Cai et al. 2010).

KAT8 is also the catalytic subunit of the male-specific lethal (MSL) complex, which acetylates almost exclusively H4K16 and is responsible for a large fraction of H4K16 acetylation in human cells (Smith et al. 2005).

N.B. Coordinates of post-translational modifications described here follow UniProt standard practice whereby coordinates refer to the translated protein before any further processing. Histone literature typically refers to coordinates of the protein after the initiating methionine has been removed. Therefore the coordinates of post-translated residues in the Reactome database and described here are frequently +1 when compared with the literature.

Literature References
PubMed ID Title Journal Year
20018852 Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex

Cai, Y, Jin, J, Swanson, SK, Cole, MD, Choi, SH, Florens, LA, Washburn, MP, Conaway, JW, Conaway, RC

J. Biol. Chem. 2010
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
histone acetyltransferase activity of NSL [nucleoplasm]
Physical Entity
NSL [nucleoplasm]
Activity
histone acetyltransferase activity (0004402)
Orthologous Events
NSL acetylates histone H4 (Bos taurus)
NSL acetylates histone H4 (Canis familiaris)
NSL acetylates histone H4 (Danio rerio)
NSL acetylates histone H4 (Drosophila melanogaster)
NSL acetylates histone H4 (Gallus gallus)
NSL acetylates histone H4 (Mus musculus)
NSL acetylates histone H4 (Rattus norvegicus)
NSL acetylates histone H4 (Sus scrofa)
NSL acetylates histone H4 (Taeniopygia guttata)
NSL acetylates histone H4 (Xenopus tropicalis)
Authored
Jupe, S  (2013-03-12)
Reviewed
Karagiannis, T  (2013-11-18)
Created
Jupe, S  (2013-05-02)