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MCRS1 [nucleoplasm]
Stable Identifier
R-HSA-3321849
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Microspherule protein 1, MCRS1_HUMAN
Locations in the PathwayBrowser
Expand all
Chromatin organization (Homo sapiens)
Chromatin modifying enzymes (Homo sapiens)
HATs acetylate histones (Homo sapiens)
NSL acetylates histone H4 (Homo sapiens)
NSL (PHF20) [nucleoplasm] (Homo sapiens)
MCRS1 [nucleoplasm] (Homo sapiens)
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
DNA Damage Recognition in GG-NER (Homo sapiens)
XPC:RAD23:CETN2 and UV-DDB bind distorted dsDNA site (Homo sapiens)
INO80 complex [nucleoplasm] (Homo sapiens)
MCRS1 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
Formation of WDR5-containing histone-modifying complexes (Homo sapiens)
Formation of the NSL complex (Homo sapiens)
MCRS1 [nucleoplasm] (Homo sapiens)
NSL [nucleoplasm] (Homo sapiens)
NSL (PHF20) [nucleoplasm] (Homo sapiens)
MCRS1 [nucleoplasm] (Homo sapiens)
NSL (PHF20L1) [nucleoplasm] (Homo sapiens)
MCRS1 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
UCH proteinases (Homo sapiens)
UCHL5 binds INO80 complex (Homo sapiens)
INO80 complex [nucleoplasm] (Homo sapiens)
MCRS1 [nucleoplasm] (Homo sapiens)
UCHL5:INO80 complex [nucleoplasm] (Homo sapiens)
INO80 complex [nucleoplasm] (Homo sapiens)
MCRS1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96EZ8 MCRS1
Gene Names
MCRS1, INO80Q, MSP58
Chain
chain:1-462
Reference Genes
BioGPS Gene:10445 MCRS1
COSMIC (genes):MCRS1 MCRS1
CTD Gene:10445 MCRS1
dbSNP Gene:10445 MCRS1
ENSEMBL:ENSG00000187778 MCRS1
ENSEMBL_homo_sapiens_GENE:ENSG00000187778.14 MCRS1
HGNC:6960 MCRS1
KEGG Gene (Homo sapiens):10445 MCRS1
Monarch:10445 MCRS1
NCBI Gene:10445 MCRS1
OMIM:609504 MCRS1
UCSC:Q96EZ8 MCRS1
Reference Transcript
RefSeq:NM_006337.4 MCRS1
RefSeq:NM_001278341.1 MCRS1
RefSeq:XM_017018689.1 MCRS1
RefSeq:XM_005268572.3 MCRS1
RefSeq:NM_001012300.1 MCRS1
RefSeq:XM_017018690.1 MCRS1
Other Identifiers
10445
11718162_a_at
16764348
202556_PM_s_at
202556_s_at
33898_at
3453905
3453906
3453908
3453910
3453912
3453914
3453916
3453917
3453920
3453921
3453922
3453923
3453925
3453926
3453928
3453929
3453930
3453933
3453934
3453937
7963064
A_23_P48237
GE81623
GO:0000123
GO:0000228
GO:0000723
GO:0002151
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005844
GO:0006260
GO:0006275
GO:0006281
GO:0006282
GO:0006310
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006974
GO:0008266
GO:0010521
GO:0030425
GO:0031011
GO:0032200
GO:0033044
GO:0034046
GO:0036211
GO:0043204
GO:0043226
GO:0044545
GO:0045739
GO:0045893
GO:0045944
GO:0045995
GO:0048856
GO:0051571
GO:0051726
GO:0051974
GO:0060382
GO:0071339
GO:0098772
GO:1904357
GO:1904507
GO:1904751
HMNXSV003025875
ILMN_1713147
ILMN_1784227
PH_hs_0002226
TC12001478.hg
TC12002870.hg
g5453693_3p_a_at
Participates
as a component of
NSL (PHF20L1) [nucleoplasm] (Homo sapiens)
NSL (PHF20) [nucleoplasm] (Homo sapiens)
INO80 complex [nucleoplasm] (Homo sapiens)
as an input of
Formation of the NSL complex (Homo sapiens)
Inferred To
Mcrs1 [nucleoplasm]
(Mus musculus)
Mcrs1 [nucleoplasm]
(Rattus norvegicus)
MCRS1 [nucleoplasm]
(Bos taurus)
MCRS1 [nucleoplasm]
(Canis familiaris)
MCRS1 [nucleoplasm]
(Gallus gallus)
MCRS1 [nucleoplasm]
(Sus scrofa)
mcrs1 [nucleoplasm]
(Xenopus tropicalis)
Rcd5 [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
XP_005268629.1
,
XP_016874178.1
,
NP_001265270.1
,
NP_001012300.1
,
XP_016874179.1
,
NP_006328.2
OpenTargets
ENSG00000187778
GeneCards
Q96EZ8
HPA
ENSG00000187778-MCRS1
Ensembl
ENSP00000349640
,
ENST00000343810
,
ENSP00000345358
,
ENSP00000444982
,
ENST00000357123
,
ENST00000550165
,
ENSG00000187778
,
ENSP00000448056
,
ENST00000546244
PRO
Q96EZ8
Pharos - Targets
Q96EZ8
Interactors (126)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y3C0 WASC3
0.879
13
UniProt:Q8NBZ0 INO80E
1
INO80E [nucleoplasm]
(R-HSA-5689552)
0.845
11
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.793
11
UniProt:O15209 ZBT22
0.718
6
UniProt:Q8N6Y0 USBP1
0.718
6
UniProt:Q9Y2W2 WBP11
1
WBP11 [nucleoplasm]
(R-HSA-8867887)
0.696
5
UniProt:Q86WP2 GPBP1
0.696
5
UniProt:P25490 YY1
1
YY1 [nucleoplasm]
(R-HSA-4086091)
0.671
4
UniProt:Q8TBK6 ZCH10
0.666
4
UniProt:Q9C0F1 CEP44
0.666
6
UniProt:Q13422 IKZF1
0.666
4
UniProt:Q2T9L4 INSY1
0.666
4
UniProt:P51116 FXR2
0.666
4
UniProt:P57055 DSCR6
0.666
4
UniProt:O94972 TRIM37
1
TRIM37 [cytosol]
(R-HSA-976049)
0.666
4
UniProt:Q9NPJ6 MED4
1
MED4 [nucleoplasm]
(R-HSA-350263)
0.666
4
UniProt:Q96S65 CSRN1
0.666
4
UniProt:Q9BQD3 KXDL1
0.666
4
UniProt:P61964 WDR5
1
WDR5 [nucleoplasm]
(R-HSA-1629838)
0.643
3
UniProt:Q96CN9 GCC1
1
GCC1 [cytosol]
(R-HSA-6813877)
0.621
3
UniProt:Q9D1P2
1
KAT8 [nucleoplasm]
(R-MMU-3321802)
0.564
2
UniProt:Q6NT76 HMBX1
0.556
8
UniProt:O60759 CYTIP
0.556
3
UniProt:Q92764 KRT35
1
KRT35 [cytosol]
(R-HSA-6809595)
0.556
3
UniProt:P38432 COIL
0.556
3
UniProt:Q86TJ2-3 Q86TJ23
0.556
3
UniProt:P19237 TNNI1
1
TNNI1 [cytosol]
(R-HSA-390539)
0.556
3
UniProt:Q8TD31-3 CCHCR1
0.556
3
UniProt:P51114-2 FXR1
0.556
3
UniProt:Q8NHQ1 CEP70
1
CEP70 [cytosol]
(R-HSA-380257)
0.556
3
UniProt:Q8N137 CNTRB
0.556
3
UniProt:A7MD48 SRRM4
0.556
3
UniProt:Q9BYR9 KRTAP2-4
1
KRTAP2-4 [cytosol]
(R-HSA-6809951)
0.556
3
UniProt:P60409 KRTAP10-7
1
KRTAP10-7 [cytosol]
(R-HSA-6810279)
0.556
3
UniProt:Q53TS8 CTSRT
0.556
3
UniProt:Q96KB5 TOPK
0.556
3
UniProt:Q9HCU9 BRMS1
1
BRMS1 [nucleoplasm]
(R-HSA-4650034)
0.556
3
UniProt:O60861-1 GAS7
0.556
3
UniProt:Q14919 DRAP1
1
DRAP1 [nucleoplasm]
(R-HSA-1226029)
0.556
3
UniProt:Q8IZU1 FAM9A
0.556
3
UniProt:O43586 PSTPIP1
1
PSTPIP1 [cytosol]
(R-HSA-879220)
0.556
3
UniProt:Q86VR2 RETR3
0.556
3
UniProt:Q08117-2 TLE5
0.556
3
UniProt:Q8N302 AGGF1
2
AGGF(1-290)-RAF1(279-648) fusion [cytosol]
(R-HSA-6802255)
AGGF(1-290)-p-RAF1(279-648) fusion [cytosol]
(R-HSA-6802507)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q9H0E9-2 BRD8
0.556
3
UniProt:Q5PSV4 BRM1L
0.556
5
UniProt:Q8NA61-2 CBY2
0.556
3
UniProt:P45984 MAPK9
3
MAPK9 [cytosol]
(R-HSA-450355)
p-T183,Y185-MAPK9 [cytosol]
(R-HSA-450293)
p-T183,Y185-MAPK9 [nucleoplasm]
(R-HSA-450319)
0.556
3
UniProt:Q6PEW1 ZCH12
0.556
3
UniProt:Q9UKT9 IKZF3
0.556
3
UniProt:P55040 GEM
1
GEM [plasma membrane]
(R-HSA-9769962)
0.556
3
UniProt:O75971-2 SNAPC5
0.556
3
UniProt:Q15276 RABEP1
1
RABEP1 [early endosome membrane]
(R-HSA-2029004)
0.556
3
IntAct:EBI-16435328 CCSB ORF ID
0.556
3
UniProt:Q96KQ4 PPP1R13B
1
PPP1R13B [nucleoplasm]
(R-HSA-6799775)
0.556
3
UniProt:Q01664 TFAP4
0.556
3
UniProt:Q9H2S9 IKZF4
0.556
3
UniProt:Q9H3D4 TP63
1
TP63 [nucleoplasm]
(R-HSA-2997585)
0.556
3
UniProt:Q13422-7 IKZF1
0.556
3
UniProt:Q15025 TNIP1
1
TNIP1 [cytosol]
(R-HSA-5690853)
0.556
3
UniProt:Q8IYE1 CCD13
0.556
6
UniProt:Q9Y250 LZTS1
0.556
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
0.556
3
IntAct:EBI-23710320 CCSB ORF ID
0.556
3
UniProt:Q96KN3 PKNX2
0.556
3
UniProt:Q02446 SP4
0.556
3
UniProt:Q96GN5 CDA7L
0.556
6
UniProt:Q9Y649 Q9Y649
0.556
3
UniProt:Q8TC99 FNDC8
0.556
3
UniProt:Q9BYV9 BACH2
0.556
3
UniProt:Q9H257-2 CARD9
0.556
3
UniProt:Q4G0R1 Q4G0R1
0.556
3
UniProt:O95251 KAT7
1
KAT7 [nucleoplasm]
(R-HSA-3321823)
0.556
3
UniProt:Q5T5X7 BEND3
0.556
3
UniProt:Q8N344 MIER2
0.556
5
UniProt:O95810 CAVN2
0.556
3
UniProt:O75420 GGYF1
0.556
3
UniProt:P01112 HRAS
20
HRAS Q61R [plasma membrane]
(R-HSA-6802458)
HRAS Q61L [plasma membrane]
(R-HSA-6802452)
HRAS Q61K [plasma membrane]
(R-HSA-6802442)
HRAS G13R [plasma membrane]
(R-HSA-6802368)
HRAS G12V [plasma membrane]
(R-HSA-6802350)
HRAS G12S [plasma membrane]
(R-HSA-6802343)
HRAS T58I [plasma membrane]
(R-HSA-9656014)
HRAS G13C [plasma membrane]
(R-HSA-9656008)
HRAS K117R [plasma membrane]
(R-HSA-9656010)
HRAS G13V [plasma membrane]
(R-HSA-9656579)
HRAS G13D [plasma membrane]
(R-HSA-9656572)
HRAS G13S [plasma membrane]
(R-HSA-9656574)
HRAS K117N [plasma membrane]
(R-HSA-9656603)
HRAS G12D [plasma membrane]
(R-HSA-9656564)
HRAS G12C [plasma membrane]
(R-HSA-9656561)
HRAS [plasma membrane]
(R-HSA-62717)
S-Farn-Me HRAS [plasma membrane]
(R-HSA-9665052)
S-Farn-Me PalmS HRAS [Golgi membrane]
(R-HSA-9647896)
S-Farn-Me HRAS [endoplasmic reticulum membrane]
(R-HSA-9647796)
S-Farn-HRAS [endoplasmic reticulum membrane]
(R-HSA-9647788)
0.556
3
UniProt:Q9H4L5 OSBPL3
1
OSBPL3 [cytosol]
(R-HSA-8867532)
0.556
3
UniProt:Q96ED9-2 HOOK2
0.556
3
IntAct:EBI-22395812 CCSB ORF ID
0.556
3
UniProt:P17098 ZNF8
0.556
3
UniProt:P41227 NAA10
0.556
3
IntAct:EBI-23624784 CCSB ORF ID
0.556
3
UniProt:Q96N16 JKIP1
0.556
3
UniProt:Q9UID6 ZN639
0.556
3
UniProt:Q8N8K9 K1958
0.556
3
UniProt:P51946 CCNH
1
CCNH [nucleoplasm]
(R-HSA-69220)
0.556
3
UniProt:P43360 MAGA6
0.556
3
UniProt:Q6ZUT1 NKAP1
0.556
6
UniProt:Q96B23 ARK2N
0.556
5
UniProt:A1L4K1 FSD2
0.556
3
UniProt:Q8WWF3 SSMM1
0.556
3
UniProt:Q15154-3 PCM1
0.556
3
UniProt:P17027 ZNF23
1
ZNF23 [nucleoplasm]
(R-HSA-1027395)
0.556
3
UniProt:O60447 EVI5
0.556
3
UniProt:Q8WV44 TRIM41
1
TRIM41 [cytosol]
(R-HSA-5688975)
0.556
3
UniProt:Q63ZY3 KANK2
0.556
3
UniProt:O14492-2 O144922
0.556
3
UniProt:P50221 MEOX1
0.556
3
UniProt:Q7RTU4 BHA09
0.556
3
UniProt:Q7Z3K6-2 MIER3
0.556
3
UniProt:O14503 BHLHE40
1
BHLHE40 [nucleoplasm]
(R-HSA-879741)
0.556
3
UniProt:Q86TI0 TBC1D1
2
TBC1D1 [cytoplasmic vesicle membrane]
(R-HSA-1454718)
p-S237-TBC1D1 [cytosol]
(R-HSA-1454673)
0.556
3
UniProt:Q9Y2T1 AXIN2
4
AXIN2 [cytosol]
(R-HSA-3640821)
RibC-AXIN2 [cytosol]
(R-HSA-3640842)
Ub-RibC-AXIN2 [cytosol]
(R-HSA-3640859)
ub-AXIN2 [cytosol]
(R-HSA-4641131)
0.556
3
UniProt:Q68CJ9 CREB3L3
10
CREB3L3(1-?) [nucleoplasm]
(R-HSA-6784629)
CREB3L3(1-?) [cytosol]
(R-HSA-6784654)
CREB3L3 [endoplasmic reticulum membrane]
(R-HSA-6784669)
CREB3L3(?-461) [endoplasmic reticulum membrane]
(R-HSA-6784710)
CREB3L3 [Golgi membrane]
(R-HSA-8874144)
CREB3L3(365-461) [Golgi membrane]
(R-HSA-8874130)
CREB3L3(1-364) [Golgi membrane]
(R-HSA-8874158)
CREB3L3(1-323) [cytosol]
(R-HSA-8874214)
CREB3L3(1-323) [nucleoplasm]
(R-HSA-8874217)
CREB3L3(324-364) [Golgi membrane]
(R-HSA-8874183)
0.556
3
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:Q9H2G4 TSPYL2
1
TSPYL2 [nucleoplasm]
(R-HSA-535540)
0.556
5
UniProt:P55081 MFAP1
1
MFAP1 [nucleoplasm]
(R-HSA-2396419)
0.556
3
UniProt:P50548 ERF
3
p-T526-ERF [nucleoplasm]
(R-HSA-3209166)
p-T526-ERF [cytosol]
(R-HSA-3209167)
ERF [nucleoplasm]
(R-HSA-2534321)
0.556
3
UniProt:Q9UGI0 ZRANB1
1
ZRANB1 [cytosol]
(R-HSA-6781939)
0.556
3
UniProt:Q99683 MAP3K5
1
MAP3K5 [cytosol]
(R-HSA-167709)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.556
3
UniProt:Q15742 NAB2
1
NAB2 [nucleoplasm]
(R-HSA-9612177)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:P10276 RARA
3
SUMO2-K166,177,399-p-S219,269-RARA [nucleoplasm]
(R-HSA-5334830)
polySUMO2-K166,K171,K399-RARA [nucleoplasm]
(R-HSA-4341042)
RARA [nucleoplasm]
(R-HSA-446164)
0.556
3
UniProt:P0C1Z6 TFPT
1
TFPT [nucleoplasm]
(R-HSA-5689542)
0.527
2
UniProt:Q9Y265 RUVBL1
1
RUVBL1 [nucleoplasm]
(R-HSA-418323)
0.527
4
UniProt:Q9ULG1 INO80
1
INO80 [nucleoplasm]
(R-HSA-5688910)
0.527
2
UniProt:Q6PI98 INO80C
1
INO80C [nucleoplasm]
(R-HSA-5689605)
0.527
2
UniProt:Q9Y230 RUVBL2
1
RUVBL2 [nucleoplasm]
(R-HSA-418321)
0.527
3
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.527
2
UniProt:Q8IXK0 PHC2
1
PHC2 [nucleoplasm]
(R-HSA-389112)
0.508
2
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