Reactome | KAT5 [nucleoplasm]

KAT5 [nucleoplasm]

Stable Identifier

R-HSA-3321979

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone acetyltransferase KAT5, KAT5_HUMAN, Tip60

Locations in the PathwayBrowser for interactor IntAct:EBI-10171679

Expand all

External Reference Information

External Reference

UniProt:Q92993 KAT5

Gene Names

KAT5, HTATIP, TIP60

Chain

chain:1-513

Reference Genes

BioGPS Gene:10524 KAT5

COSMIC (genes):KAT5 KAT5

CTD Gene:10524 KAT5

dbSNP Gene:10524 KAT5

ENSEMBL:ENSG00000172977 KAT5

HGNC:5275 KAT5

KEGG Gene (Homo sapiens):10524 KAT5

Monarch:10524 KAT5

NCBI Gene:10524 KAT5

OMIM:601409 KAT5

UCSC:Q92993 KAT5

Reference Transcript

Other Identifiers

0006840167

0007000601

10524

11722613_a_at

16727045

206689_x_at

209192_x_at

214258_x_at

3335520

3335521

3335522

3335523

3335524

3335526

3335527

3335530

3335533

3335534

3335535

3335536

3335538

3335541

3335542

3335546

3335549

3335551

3335552

3335553

465_at

7941382

A_14_P100655

A_14_P136045

A_23_P138849

GE59393

GO:0000122

GO:0000228

GO:0000729

GO:0000785

GO:0000812

GO:0003674

GO:0003712

GO:0003713

GO:0004402

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005730

GO:0005737

GO:0006259

GO:0006260

GO:0006302

GO:0006303

GO:0006325

GO:0006355

GO:0006357

GO:0006464

GO:0006914

GO:0006950

GO:0006978

GO:0007165

GO:0008134

GO:0008150

GO:0009056

GO:0009058

GO:0010212

GO:0010508

GO:0016032

GO:0016407

GO:0016573

GO:0016740

GO:0016746

GO:0018215

GO:0018394

GO:0022607

GO:0032703

GO:0032777

GO:0032991

GO:0034641

GO:0035267

GO:0040007

GO:0040008

GO:0042393

GO:0043161

GO:0043167

GO:0043226

GO:0044403

GO:0045892

GO:0045893

GO:0045944

GO:0046872

GO:0048471

GO:0051276

GO:0061733

GO:0065003

GO:0070491

GO:0071392

GO:1901796

GO:1901985

GO:1904837

HMNXSV003046853

Hs.6364.4.A1_3p_a_at

ILMN_1724138

ILMN_1759789

ILMN_2414366

PH_hs_0030021

TC11000640.hg

U74667_at

Participates

as a member of

histone acetyltransferases [nucleoplasm] (Homo sapiens)

as a component of

as an output of

as an input of

Beta-catenin recruits TRRAP/KAT5 HAT components (Homo sapiens)

Inferred To

ESA1 [nucleoplasm] (Saccharomyces cerevisiae)

kat5b [nucleoplasm] (Danio rerio)

KAT5 [nucleoplasm] (Bos taurus)

KAT5 [nucleoplasm] (Canis familiaris)

KAT5 [nucleoplasm] (Dictyostelium discoideum)

KAT5 [nucleoplasm] (Gallus gallus)

KAT5 [nucleoplasm] (Plasmodium falciparum)

KAT5 [nucleoplasm] (Sus scrofa)

Tip60 [nucleoplasm] (Drosophila melanogaster)

mys-1 [nucleoplasm] (Caenorhabditis elegans)

Kat5 [nucleoplasm] (Mus musculus)

Kat5 [nucleoplasm] (Rattus norvegicus)

mst1 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_006379.2, NP_001193762.1, NP_874368.1, NP_874369.1

OpenTargets

ENSG00000172977

ZINC - Substances

KAT5_HUMAN

ZINC target

Q92993

ZINC - Biogenic

KAT5_HUMAN

PRO

Q92993

PDB

2OU2, 2EKO, 4QQG

IntEnz

2.3.1.48

HPA

ENSG00000172977-KAT5

GeneCards

Q92993

Ensembl

ENSP00000366245, ENST00000377046, ENST00000352980, ENSP00000340330, ENSP00000344955, ENSG00000172977, ENST00000341318, ENST00000530446, ENSP00000434765

ZINC - Predictions - Purchasable

KAT5_HUMAN

HMDB Protein

HMDBP00036

Interactors (229)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.758	5
UniProt:Q9NV56 MRGBP	1	MRGBP [nucleoplasm] (R-HSA-3322953)	0.737	6
UniProt:Q53FD0-2 ZC2HC1C			0.718	6
UniProt:Q9UKT9 IKZF3			0.718	6
UniProt:Q9BRK4 LZTS2			0.718	6
UniProt:Q6NT76 HMBX1			0.718	6
UniProt:O75558 STX11			0.718	6
UniProt:Q9NQM4 DAAF6			0.718	6
UniProt:P11926 ODC1	1	PXLP-K69-ODC1 [cytosol] (R-HSA-70689)	0.718	6
UniProt:P54253 ATX1			0.709	9
UniProt:Q96IK5 GMCL1			0.696	5
UniProt:P62805 H4C1	19	SUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) HIST1H4A [extracellular region] (R-HSA-977569) SUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-4568749) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK-HIST1H4A [nucleoplasm] (R-HSA-2172676) HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652)	0.683	4
UniProt:Q96BR9 ZBT8A			0.666	4
UniProt:Q5JR59-3 MTUS2			0.666	4
UniProt:Q99986 VRK1	2	VRK1 [nucleoplasm] (R-HSA-2528998) VRK1 [cytosol] (R-HSA-2995381)	0.645	6
UniProt:Q96GD4 AURKB	3	AURKB [nucleoplasm] (R-HSA-4655360) SUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [cytosol] (R-HSA-174231)	0.602	4
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.573	2
UniProt:P10085 Myod1	2	Myod1 [nucleoplasm] (R-MMU-445441) MYOD1_MOUSE [nucleoplasm] (R-MMU-448840)	0.571	5
IntAct:EBI-15634422 H3K9-2			0.558	3
UniProt:Q15906 VPS72	1	VPS72 [nucleoplasm] (R-HSA-3321992)	0.558	3
UniProt:Q5JUW0-3 KRBOX4			0.556	3
UniProt:Q6ZSJ9 SHSA6			0.556	3
UniProt:Q02363 ID2	1	ID2 [nucleoplasm] (R-HSA-452391)	0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
IntAct:EBI-25901731 CCSB			0.556	3
UniProt:Q9BU19 ZNF692	1	ZNF692 [nucleoplasm] (R-HSA-2454144)	0.556	3
UniProt:Q9UJD0 RIMS3			0.556	3
IntAct:EBI-25884997 CCSB			0.556	3
UniProt:Q96NE9-2 FRMD6			0.556	3
UniProt:P62913-2 RPL11			0.556	3
UniProt:P41218 MNDA	3	MNDA [extracellular region] (R-HSA-6806244) MNDA [ficolin-1-rich granule lumen] (R-HSA-6800897) MNDA [azurophil granule lumen] (R-HSA-6799237)	0.556	3
UniProt:O00165 HAX1			0.556	3
UniProt:Q86WR7-2 PROSER2			0.556	3
UniProt:P26951 IL3RA	1	IL3RA [plasma membrane] (R-HSA-879938)	0.556	3
UniProt:Q96FT9-2 IFT43			0.556	3
UniProt:Q9H8H3 METTL7A	2	METTL7A [tertiary granule lumen] (R-HSA-6800170) METTL7A [extracellular region] (R-HSA-6800468)	0.556	3
UniProt:O15535 ZSC9			0.556	3
UniProt:Q8N983-3 MRPL43			0.556	3
UniProt:Q9NQX0 PRDM6			0.556	3
UniProt:Q2M1J6 Q2M1J6			0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:Q8N5Z5 KCD17			0.556	3
UniProt:Q9UM82 SPAT2			0.556	3
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:Q14202 ZMYM3			0.556	3
UniProt:Q15776 ZKSCAN8	1	ZKSCAN8 [nucleoplasm] (R-HSA-974985)	0.556	3
UniProt:P21728 DRD1	1	DRD1 [plasma membrane] (R-HSA-390853)	0.556	3
UniProt:Q13033-2 STRN3			0.556	3
UniProt:P15169 CPN1	1	CPN1 [extracellular region] (R-HSA-8852824)	0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q9NZ72 STMN3			0.556	3
IntAct:EBI-16435328 CCSB ORF ID			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q01105-2 SET			0.556	3
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q99828 CIB1			0.556	3
UniProt:Q7Z699 SPRED1	2	SPRED1 [cytosol] (R-HSA-5654207) SPRED1 [plasma membrane] (R-HSA-5658225)	0.556	3
UniProt:Q9NWS8-3 RMND1			0.556	3
UniProt:Q8N7T0 Q8N7T0			0.556	3
UniProt:Q8N8E2 ZN513			0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:O95424 DEXI			0.556	3
UniProt:Q15759 MAPK11	4	p-T180,Y182-MAPK11 [cytosol] (R-HSA-171009) MAPK11 [cytosol] (R-HSA-170989) MAPK11 [nucleoplasm] (R-HSA-203790) p-T180,Y182-MAPK11 [nucleoplasm] (R-HSA-198741)	0.556	3
UniProt:Q9H2F5-2 EPC1			0.556	3
UniProt:Q99643 SDHC	1	SDHC [mitochondrial inner membrane] (R-HSA-70988)	0.556	3
UniProt:Q9UNA4 POLI	1	POLI [nucleoplasm] (R-HSA-5656133)	0.556	3
UniProt:Q9NPJ3 ACOT13	1	ACOT13 [cytosol] (R-HSA-5690048)	0.556	3
UniProt:Q96I34 PP16A			0.556	3
UniProt:O43307 ARHGEF9	1	ARHGEF9 [cytosol] (R-HSA-195067)	0.556	3
UniProt:Q03933-2 HSF2			0.556	3
UniProt:Q13586 STIM1	1	STIM1 [endoplasmic reticulum membrane] (R-HSA-434675)	0.556	3
UniProt:Q96A33 CCD47			0.556	3
UniProt:O14926 FSCN2	1	FSCN2 [cytosol] (R-HSA-9662384)	0.556	3
UniProt:Q9NWQ4-1 GPATCH2L			0.556	3
UniProt:Q96J88-3 Q96J883			0.556	3
UniProt:Q9BW85 YJU2			0.556	3
UniProt:Q9Y508 RNF114	1	RNF114 [cytosol] (R-HSA-8850894)	0.556	3
UniProt:Q9Y2K1 ZBTB1			0.556	3
UniProt:Q6PH81 CP087			0.556	3
UniProt:Q5VSY0 GKAP1			0.556	3
IntAct:EBI-25902328 CCSB			0.556	3
UniProt:Q92673 SORL1	2	SORL1 [Golgi membrane] (R-HSA-8871510) SORL1 [endosome membrane] (R-HSA-8871475)	0.556	3
UniProt:Cerebral CLONE			0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:Q8WV41 SNX33			0.556	3
IntAct:EBI-25857950 CCSB			0.556	3
UniProt:Q6P1J6-2 PLB1			0.556	3
UniProt:O00505 KPNA3	2	KPNA3 [cytosol] (R-HSA-1176070) KPNA3 [nucleoplasm] (R-HSA-1176061)	0.556	3
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.556	3
UniProt:Q7Z7K6 CENPV			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:A0JLT2-2 MED19			0.556	3
UniProt:Q16718 NDUFA5	2	NDUFA5 [mitochondrial inner membrane] (R-HSA-60599) NDUFA5 [endoplasmic reticulum membrane] (R-HSA-9714749)	0.556	3
UniProt:P62837 UBE2D2	4	Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214) Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153) UBE2D2 [nucleoplasm] (R-HSA-8852067) UBE2D2 [cytosol] (R-HSA-934628)	0.556	3
UniProt:Q8IWZ3-3 ANKHD1			0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	3
UniProt:O60684 IMA7			0.556	3
UniProt:Q8IVH2-2 Q8IVH22			0.556	3
UniProt:Q16254 E2F4	1	E2F4 [nucleoplasm] (R-HSA-68664)	0.556	3
UniProt:Q9Y5X0 SNX10			0.556	3
UniProt:P50570-2 DNM2			0.556	3
UniProt:Q92481 TFAP2B	2	TFAP2B [nucleoplasm] (R-HSA-3234060) SUMO1-K21-TFAP2B [nucleoplasm] (R-HSA-3234107)	0.556	3
UniProt:Q9BQ24 ZFY21			0.556	3
UniProt:Q86Z20 CC125			0.556	3
UniProt:P01023 A2M	2	A2M [extracellular region] (R-HSA-49291) A2M [platelet alpha granule lumen] (R-HSA-139834)	0.556	3
UniProt:Q9H2C1 LHX5			0.556	3
UniProt:Q96MP8-2 KCTD7			0.556	3
UniProt:O00213-2 APBB1			0.556	3
UniProt:Q9BYR8 KRTAP3-1	1	KRTAP3-1 [cytosol] (R-HSA-6809868)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q17RB8 LONRF1	1	LONRF1 [cytosol] (R-HSA-8850905)	0.556	3
UniProt:Q02535 ID3	1	ID3 [nucleoplasm] (R-HSA-9613379)	0.556	3
UniProt:P78318 IGBP1			0.556	3
UniProt:A0A0C3SFZ9 A0A0C3SFZ9			0.556	3
UniProt:Q8TF42 UBS3B			0.556	3
UniProt:P43234 CTSO	1	CTSO [lysosomal lumen] (R-HSA-1181227)	0.556	3
UniProt:Q9Y576 ASB1	1	ASB1 [cytosol] (R-HSA-975428)	0.556	3
UniProt:Q9H213 MAGH1			0.556	3
UniProt:Q96HJ3-2 Q96HJ32			0.556	3
UniProt:Q8NEA9 GMCL2			0.556	3
UniProt:Q8NDD1-6 Q8NDD16			0.556	3
UniProt:P60228 EIF3E	1	EIF3E [cytosol] (R-HSA-72552)	0.556	3
UniProt:Q96BW1 UPP			0.556	3
UniProt:Q66PJ3-4 ARL6IP4			0.556	3
IntAct:EBI-25876377 CCSB			0.556	3
UniProt:Q96JN2-2 CCDC136			0.556	3
UniProt:Q06547-2 GABPB1	1	NRF2 beta-2 subunit [nucleoplasm] (R-HSA-1592200)	0.556	3
UniProt:P35711 SOX5			0.556	3
UniProt:Q9GZT6 CC90B			0.556	3
UniProt:O95837 GNA14	1	GNA14 [plasma membrane] (R-HSA-167453)	0.556	3
UniProt:Q96I51 RCC1L			0.556	3
UniProt:Q15027 ACAP1			0.556	3
UniProt:Q9NNX1 TUFT1			0.556	3
UniProt:P23508 CRCM			0.556	3
UniProt:O43761 SNG3			0.556	3
UniProt:Q9Y250 LZTS1			0.556	3
UniProt:O14656-2 TOR1A			0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q9UL40 ZN346			0.556	3
UniProt:Q99598 TSNAX	1	TSNAX [cytosol] (R-HSA-5216130)	0.556	3
UniProt:Q53SE7 Q53SE7			0.556	3
UniProt:P29084 GTF2E2	1	GTF2E2 [nucleoplasm] (R-HSA-65563)	0.556	3
UniProt:O94972 TRIM37	1	TRIM37 [cytosol] (R-HSA-976049)	0.556	3
UniProt:Q9H2G9 BLZF1	1	BLZF1 [Golgi membrane] (R-HSA-2422372)	0.556	3
UniProt:P18077 RPL35A	1	RPL35A [cytosol] (R-HSA-72462)	0.556	3
UniProt:D3DTS7 D3DTS7			0.556	3
UniProt:Q969K7 TMM54			0.556	3
UniProt:Q9BYV9 BACH2			0.556	3
UniProt:P56693 SOX10	1	SOX10 [nucleoplasm] (R-HSA-9613639)	0.556	3
UniProt:Q05CR2 Q05CR2			0.556	3
UniProt:Q9ULK6-3 Q9ULK63			0.556	3
UniProt:Q13072 BAGE1			0.556	3
UniProt:Q16342 PDCD2			0.556	3
UniProt:Q9HBH6 Q9HBH6			0.556	3
UniProt:Q8NB14 UBP38			0.556	3
UniProt:O95498 VNN2	3	GPI-VNN2 [plasma membrane] (R-HSA-8940753) cleaved GPI-VNN2 [extracellular region] (R-HSA-8941027) VNN2 [plasma membrane] (R-HSA-2980905)	0.556	3
UniProt:Q8NB15 ZN511			0.556	3
UniProt:O75420 GGYF1			0.556	3
UniProt:O43829 ZBT14			0.556	3
UniProt:Q9UJA5 TRMT6	1	TRMT6 [nucleoplasm] (R-HSA-6783485)	0.556	3
IntAct:EBI-22370853 CCSB ORF ID			0.556	3
UniProt:Q96FV2 SCRN2			0.556	3
UniProt:Q8N0Y2-2 ZNF444			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P80192 M3K9			0.556	3
UniProt:Q9NZC7-5 WWOX			0.556	3
UniProt:Q8NAM6 ZSCA4			0.556	3
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P20042 EIF2S2	1	EIF2S2 [cytosol] (R-HSA-72512)	0.556	3
IntAct:EBI-25902722 CCSB			0.556	3
UniProt:Q3YBM2 T176B			0.556	3
UniProt:Q8TF50 ZN526			0.556	3
UniProt:Q3YEC7-3 Q3YEC73			0.556	3
UniProt:Q92826 HXB13			0.556	3
UniProt:Q15699 ALX1			0.556	3
UniProt:Q8N680 ZBTB2			0.556	3
UniProt:Q9Y2D8 ADIP			0.556	3
UniProt:Q14141 SEPT6			0.556	3
UniProt:Q9BRX2 PELO			0.556	3
UniProt:Q14140 SRTD2			0.556	3
UniProt:Q8IY31-3 IFT20			0.556	3
UniProt:Q96GV9 MACIR			0.556	3
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.556	3
UniProt:O43292-2 O432922			0.556	3
UniProt:P50222 MEOX2			0.556	3
UniProt:P19440-3 P194403			0.556	3
UniProt:Q96F32 Q96F32			0.556	3
UniProt:Q8IXK0 PHC2	1	PHC2 [nucleoplasm] (R-HSA-389112)	0.556	3
UniProt:Q9Y4X4 KLF12			0.556	3
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.556	3
UniProt:P17936 IGFBP3	15	IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956748) IGFBP3 [extracellular region] (R-HSA-381512) p-IGFBP3 [endoplasmic reticulum lumen] (R-HSA-8956963) IGFBP3(125-233) [extracellular region] (R-HSA-381465) IGFBP3(28-124) [extracellular region] (R-HSA-381547) IGFBP3(234-291) [extracellular region] (R-HSA-381546) IGFBP3(125-187) [extracellular region] (R-HSA-381507) IGFBP3(188-291) [extracellular region] (R-HSA-381471) IGFBP3(28-168) [extracellular region] (R-HSA-381489) IGFBP3(227-291) [extracellular region] (R-HSA-538718) IGFBP3(169-226) [extracellular region] (R-HSA-381499) IGFBP3(127-291) [extracellular region] (R-HSA-381455) IGFBP3(28-126) [extracellular region] (R-HSA-381534) IGFBP3(291-187) [extracellular region] (R-HSA-381410) IGFBP3(28-186) [extracellular region] (R-HSA-381454)	0.556	3
UniProt:Q9NX63 CHCHD3	3	CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874907) CHCHD3 (MIC19) [mitochondrial inner membrane] (R-HSA-8949583) 4xHC-CHCHD3 [mitochondrial intermembrane space] (R-HSA-8874910)	0.556	3
UniProt:Q9Y2I6 NINL	2	NINL [cytosol] (R-HSA-380706) p-NINL [cytosol] (R-HSA-380716)	0.556	3
UniProt:Q9Y6X2 PIAS3	1	PIAS3 [nucleoplasm] (R-HSA-2993764)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [endocytic vesicle membrane] (R-HSA-417017) PICK1 [plasma membrane] (R-HSA-416989)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	15
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:O94844 RHOBTB1	1	RHOBTB1 [endosome membrane] (R-HSA-194899)	0.556	3
UniProt:Q06547-3 GABPB1	1	NRF2 gamma-1 subunit [nucleoplasm] (R-HSA-1592216)	0.556	3
UniProt:P49821 NDUFV1	1	NDUFV1 [mitochondrial inner membrane] (R-HSA-163926)	0.556	3
UniProt:Q6NZI2 CAVIN1	2	PTRF [nucleoplasm] (R-HSA-74981) CAVIN1 [plasma membrane] (R-HSA-9714278)	0.556	3
UniProt:Q9Y234 LIPT1	1	LIPT1 [mitochondrial matrix] (R-HSA-6792623)	0.556	3
UniProt:O43598 DNPH1	1	DNPH1 [cytosol] (R-HSA-8953358)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:Q14032 BAAT	2	BAAT [peroxisomal matrix] (R-HSA-193517) BAAT [cytosol] (R-HSA-159392)	0.556	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.556	3
UniProt:P51884 LUM	12	KS(2)-LUM [extracellular region] (R-HSA-2046202) LUM [extracellular region] (R-HSA-2466189) KS(2)-LUM [lysosomal lumen] (R-HSA-2046283) LUM [lysosomal lumen] (R-HSA-2104998) KS(1)-LUM [Golgi lumen] (R-HSA-2046161) KS(2)-LUM [Golgi lumen] (R-HSA-2046249) Keratan(4)-LUM [Golgi lumen] (R-HSA-2046205) Keratan(3)-LUM [Golgi lumen] (R-HSA-2046198) Keratan(2)-LUM [Golgi lumen] (R-HSA-2046233) Gal-glycan LUM [Golgi lumen] (R-HSA-2046248) Keratan(1)-LUM [Golgi lumen] (R-HSA-2046316) N-glycan LUM [Golgi lumen] (R-HSA-2046297)	0.556	3
UniProt:Q15836 VAMP3	6	VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.556	3
UniProt:P52597 HNRNPF	2	HNRNPF [plasma membrane] (R-HSA-8950714) HNRNPF [nucleoplasm] (R-HSA-71937)	0.556	3
UniProt:P04183 TK1	1	TK1 [cytosol] (R-HSA-73500)	0.556	3
UniProt:P07225 PROS1	8	11xCbxE-PROS1 [plasma membrane] (R-HSA-141004) 11xCbxE-PROS1 [extracellular region] (R-HSA-202772) PROS1(25-676) [endoplasmic reticulum membrane] (R-HSA-159758) 11xCbxE-PROS1(25-676) [endoplasmic reticulum membrane] (R-HSA-159770) 11xCbxE-PROS1(25-676) [Golgi membrane] (R-HSA-159850) PROS1(25-41) [Golgi lumen] (R-HSA-159792) 11xCbxE-PROS1 [Golgi membrane] (R-HSA-159865) 11xCbxE-PROS1 [platelet alpha granule lumen] (R-HSA-349762)	0.556	3
UniProt:Q86T03 PIP4P1	2	TMEM55B [nucleoplasm] (R-HSA-6810405) TMEM55B [late endosome membrane] (R-HSA-6810395)	0.556	3
UniProt:Q01130 SRSF2	1	SRSF2 [nucleoplasm] (R-HSA-72033)	0.544	3
UniProt:O96019 ACTL6A	1	ACTL6A [nucleoplasm] (R-HSA-2980912)	0.527	3
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.527	2
UniProt:Q01844 EWS			0.524	2
UniProt:P03372-1 ESR1			0.524	3
UniProt:Q92804 TAF15	1	TAF15 [nucleoplasm] (R-HSA-9020680)	0.524	2
UniProt:P35637 FUS	1	FUS [nucleoplasm] (R-HSA-72040)	0.524	2
UniProt:Q9P2H0 CE126			0.508	2
UniProt:O95257 GA45G			0.508	2
UniProt:O43261 LEU1			0.508	2
UniProt:P10275 AR	4	SUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984) AR [nucleoplasm] (R-HSA-446174) AR [cytosol] (R-HSA-5618082)	0.508	2
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.508	2
UniProt:P29074 PTPN4	2	PTPN4 [nucleoplasm] (R-HSA-9008925) PTPN4 [cytosol] (R-HSA-8877173)	0.508	2
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.499	3

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