Beta-catenin recruits SMARCA4

Stable Identifier
R-HSA-3322422
Type
Reaction [binding]
Species
Homo sapiens
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SMARCA4, one of two ATPase components of SWI/SNF chromatin remodelling complexes, was identified in a two-hybrid screen for beta-catenin interactors that activate TCF/LEF-dependent transcription (Barker et al, 2001; Wilson and Roberts, 2011). SMARCA4 co-immunoprecipitates with beta-catenin when both tagged proteins are expressed in HEK293 cells; likewise, tagged SMARCA4 co-precipitates endogenous beta-catenin from a colon carcinoma cell line. Expression of SMARCA4 enhances the expression of a TCF reporter in a manner that depends on a functional ATPase domain, indicating a probable role for chromatin remodelling at WNT-responsive promoters (Barker et al, 2001). By ChIP, SMARCA4 and beta-catenin are associated with WNT-responsive promoters upon WNT pathway stimulation; this study also identified TERT, a telomerase reverse transcriptase, as SMARCA4-interacting protein that is present at WNT promoters (Park et al, 2009).

Literature References
PubMed ID Title Journal Year
19571879 Telomerase modulates Wnt signalling by association with target gene chromatin

Park, JI, Venteicher, AS, Hong, JY, Choi, J, Jun, S, Shkreli, M, Chang, W, Meng, Z, Cheung, P, Ji, H, McLaughlin, M, Veenstra, TD, Nusse, R, McCrea, PD, Artandi, SE

Nature 2009
11532957 The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation

Barker, N, Hurlstone, A, Musisi, H, Miles, A, Bienz, M, Clevers, HC

EMBO J. 2001
21654818 SWI/SNF nucleosome remodellers and cancer

Wilson, BG, Roberts, CW

Nat. Rev. Cancer 2011
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