Beta-catenin recruits CBP/p300

Stable Identifier
R-HSA-3322427
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

CBP (CREB-binding protein) and the closely related p300 are histone acetyltransferases that are recruited to WNT-responsive promoters through interactions with the C-terminal half of beta-catenin (Hecht et al, 2000; Takemura and Moon, 2000; Sun et al, 2000). Although recruitment is WNT-signaling dependent and results in activation of several WNT target genes, the precise role of CBP and p300 is not yet clear. In Drosophila, recruitment of CBP can affect the acetylation of histones H3 and H4 up to 30kb away from WREs, possibly aided by the DNA bending induced by TCFs (Parker et al, 2008); in other instances, the intrinsic HAT activity has been shown to acetylate beta-catenin (Levy et al, 2004; Wolf et al, 2002), or to be dispensable for the transcriptional activation activity of CBP/p300 at WREs (Hecht et al, 2000).

Literature References
PubMed ID Title Journal Year
18160704 Wingless signaling induces widespread chromatin remodeling of target loci

Parker, DS, Ni, YY, Chang, JL, Li, J, Cadigan, KM

Mol. Cell. Biol. 2008
10775268 The p300/CBP acetyltransferases function as transcriptional coactivators of beta-catenin in vertebrates

Hecht, A, Vleminckx, K, Stemmler, MP, van Roy, F, Kemler, R

EMBO J. 2000
11973335 Acetylation of beta-catenin by CREB-binding protein (CBP)

Wolf, D, Rodova, M, Miska, EA, Calvet, JP, Kouzarides, T

J. Biol. Chem. 2002
15060161 Acetylation of beta-catenin by p300 regulates beta-catenin-Tcf4 interaction

Lévy, L, Wei, Y, Labalette, C, Wu, Y, Renard, CA, Buendia, MA, Neuveut, C

Mol. Cell. Biol. 2004
10769018 The transcriptional coactivator CBP interacts with beta-catenin to activate gene expression

Takemaru, KI, Moon, RT

J. Cell Biol. 2000
11050151 Regulation of beta -catenin transformation by the p300 transcriptional coactivator

Sun, Y, Kolligs, FT, Hottiger, MO, Mosavin, R, Fearon, ER, Nabel, GJ

Proc. Natl. Acad. Sci. U.S.A. 2000
Participants
Participant Of
Orthologous Events
Authored
Reviewed
Created