Reactome | PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O

PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O

Stable Identifier

R-HSA-3322995

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Peroxiredoxin 3 (PRDX3) and PRDX5 in the mitochondrial matrix reduce hydrogen peroxide (H2O2) with thioredoxin to yield oxidized thioredoxin and water (Yamashita et al. 1999, Knoops et al. 1999, Cao et al. 2007, Nagy et al. 2011). Reduced PRDX5 is a monomer (Declercq et al. 2001) and oxidized PRDX5 is a dimer (Evrard et al. 2004) therefore the enzyme may cycle between states.

Literature References

PubMed ID	Title	Journal	Year
11518528	Crystal structure of human peroxiredoxin 5, a novel type of mammalian peroxiredoxin at 1.5 A resolution Declercq, JP, Evrard, C, Clippe, A, Stricht, DV, Bernard, A, Knoops, B	J. Mol. Biol.	2001
15046979	Crystal structure of a dimeric oxidized form of human peroxiredoxin 5 Evrard, C, Capron, A, Marchand, C, Clippe, A, Wattiez, R, Soumillion, P, Knoops, B, Declercq, JP	J. Mol. Biol.	2004
17707404	Reconstitution of the mitochondrial PrxIII antioxidant defence pathway: general properties and factors affecting PrxIII activity and oligomeric state Cao, Z, Bhella, D, Lindsay, JG	J. Mol. Biol.	2007
10521424	Cloning and characterization of AOEB166, a novel mammalian antioxidant enzyme of the peroxiredoxin family Knoops, B, Clippe, A, Bogard, C, Arsalane, K, Wattiez, R, Hermans, C, Duconseille, E, Falmagne, P, Bernard, A	J. Biol. Chem.	1999
21385867	Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study Nagy, P, Karton, A, Betz, A, Peskin, AV, Pace, P, O'Reilly, RJ, Hampton, MB, Radom, L, Winterbourn, CC	J. Biol. Chem.	2011
10514471	Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro Yamashita, H, Avraham, S, Jiang, S, London, R, Van Veldhoven, PP, Subramani, S, Rogers, RA, Avraham, H	J. Biol. Chem.	1999