GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier
R-HSA-3323013
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Glutathione peroxidase 1 (GPX1) located in the mitochondrial matrix uses glutathione to reduce hydrogen peroxide (H2O2) to yield oxidized glutathione and water (Legault et al. 2000, Li et al. 2000, Faucher et al. 2003). As inferred from rat mitochondria, GPX1 is the major determinant of steady-state hydrogen peroxide levels (Antunes et al. 2002).

Literature References
PubMed ID Title Journal Year
12398934 Relative contributions of heart mitochondria glutathione peroxidase and catalase to H(2)O(2) detoxification in in vivo conditions

Antunes, F, Han, D, Cadenas, E

Free Radic. Biol. Med. 2002
10833429 Mitochondrial GPx1 decreases induced but not basal oxidative damage to mtDNA in T47D cells

Legault, J, Carrier, C, Petrov, P, Renard, P, Remacle, J, Mirault, ME

Biochem. Biophys. Res. Commun. 2000
10919671 The role of cellular glutathione peroxidase redox regulation in the suppression of tumor cell growth by manganese superoxide dismutase

Li, S, Yan, T, Yang, JQ, Oberley, TD, Oberley, LW

Cancer Res. 2000
12829378 Overexpression of cytosolic glutathione peroxidase (GPX1) delays endothelial cell growth and increases resistance to toxic challenges

Faucher, K, Rabinovitch-Chable, H, Barrière, G, Cook-Moreau, J, Rigaud, M

Biochimie 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutathione peroxidase activity of GPX1 tetramer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed