Reactome | 2xHC-TXN2 [mitochondrial matrix]

2xHC-TXN2 [mitochondrial matrix]

Stable Identifier

R-HSA-3323059

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

TXN2 oxidized, Thioredoxin, mitochondrial, THIOM_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
16195549	Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2 Landtmeters, M, Smeets, A, Marchand, C, Evrard, C, Knoops, B, Declercq, JP	Protein Sci.	2005

External Reference Information

External Reference

UniProt:Q99757 TXN2

Gene Names

TXN2, TRX2

Chain

transit peptide:1-59, chain:60-166

Reference Genes

BioGPS Gene:25828 TXN2

COSMIC (genes):TXN2 TXN2

CTD Gene:25828 TXN2

dbSNP Gene:25828 TXN2

ENSEMBL:ENSG00000100348 TXN2

HGNC:17772 TXN2

KEGG:hsa:25828 TXN2

Monarch:25828 TXN2

NCBI Gene:25828 TXN2

OMIM:609063 TXN2

UCSC:Q99757 TXN2

Reference Transcript

Other Identifiers

11729650_a_at

16934558

209077_PM_at

209077_at

209078_PM_s_at

209078_s_at

25828

32852_at

3959594

3959595

3959597

3959600

3959601

3959602

3959603

3959605

3959606

3959607

3959608

8075778

A_23_P68899

GE59430

GE81803

GO:0001666

GO:0003824

GO:0005515

GO:0005730

GO:0005739

GO:0005759

GO:0006979

GO:0008113

GO:0009410

GO:0009725

GO:0009749

GO:0014070

GO:0015035

GO:0016491

GO:0030425

GO:0031669

GO:0033743

GO:0043025

GO:0043226

GO:0044877

GO:0045454

GO:0048678

GO:0140096

HMNXSV003002424

Hs.211929.0.S2_3p_at

ILMN_1654457

PH_hs_0012289

TC22000709.hg

U78678_at

g9280552_3p_a_at

Participates

as an output of

as an input of

TXNRD2 catalyzes the reduction of TXN2 by NADPH (Homo sapiens)

Other forms of this molecule

TXN2 [mitochondrial matrix]

Inferred To

txn2 [mitochondrial matrix] (Danio rerio)

txn2 [mitochondrial matrix] (Xenopus tropicalis)

Dmel\CG8993 [mitochondrial matrix] (Drosophila melanogaster)

Txn2 [mitochondrial matrix] (Mus musculus)

Txn2 [mitochondrial matrix] (Rattus norvegicus)

2xHC-TXN2 [mitochondrial matrix] (Dictyostelium discoideum)

TXN2 [mitochondrial matrix] (Bos taurus)

TXN2 [mitochondrial matrix] (Gallus gallus)

TXN2 [mitochondrial matrix] (Sus scrofa)

trx-2 [mitochondrial matrix] (Caenorhabditis elegans)

Modified Residues

Name

Intra-chain Crosslink via L-cystine (cross-link) at 90 and 93

Coordinate

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Cross References

OpenTargets

ENSG00000100348

ENSEMBL

ENST00000403313, ENST00000216185, ENSP00000385393, ENSP00000216185

HPA

ENSG00000100348-TXN2

ZINC target

Q99757

PRO

Q99757

Pharos - Targets

Q99757

Orphanet

TXN2

PDB

1UVZ, 1W89, 1W4V

Interactors (79)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19474 TRIM21	1	TRIM21 [cytosol] (R-HSA-976051)	0.718	6
UniProt:P49247 RPIA	2	RPIA [cytosol] (R-HSA-71304) RPIA A61V [cytosol] (R-HSA-5660009)	0.718	6
UniProt:O43805 SSNA1	1	SSNA1 [cytosol] (R-HSA-380255)	0.718	6
UniProt:Q8N1B4 VPS52	1	VPS52 [trans-Golgi network membrane] (R-HSA-6811029)	0.718	6
UniProt:Q96CD2 PPCDC	1	PPCDC [cytosol] (R-HSA-196829)	0.718	6
UniProt:Q9UPY8 MARE3			0.718	6
UniProt:Q15555 MARE2			0.718	6
UniProt:Q96HT8 MR1L1			0.718	6
UniProt:Q8IZE3 PACE1			0.666	4
UniProt:Q96D09 GASP2			0.666	4
UniProt:Q6RW13 AGTRAP	2	AGTRAP(1-159)-BRAF(288-545) fusion [cytosol] (R-HSA-6802262) AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol] (R-HSA-6802511)	0.556	3
UniProt:Q8IZE3-2 SCYL3			0.556	3
UniProt:Q9UJ41 RABGEF1	2	RABGEF1 [early endosome membrane] (R-HSA-2029032) RABGEF1 [cytosol] (R-HSA-8875419)	0.556	3
UniProt:Q9NZQ9 TMOD4	1	TMOD4 [cytosol] (R-HSA-5694030)	0.556	3
UniProt:Q8N2N9-4 ANKRD36B			0.556	3
UniProt:Q99750 MDFI			0.556	3
UniProt:Q8NHQ1 CEP70	1	CEP70 [cytosol] (R-HSA-380257)	0.556	3
UniProt:Q6PI77 GASP3			0.556	3
IntAct:EBI-16434357 CCSB ORF ID			0.556	3
UniProt:Q9Y605 MOFA1			0.556	3
UniProt:Q96M63 ODAD1			0.556	3
UniProt:P01189 POMC	12	POMC(237-241) [extracellular region] (R-HSA-167407) POMC(237-267) [extracellular region] (R-HSA-167405) POMC(138-176) [extracellular region] (R-HSA-388607) POMC(138-150) [extracellular region] (R-HSA-388593) POMC(217-234) [extracellular region] (R-HSA-388617) POMC(77-87) [extracellular region] (R-HSA-388618) POMC(138-176) [cytosol] (R-HSA-1502544) POMC(138-176) K25* [extracellular region] (R-HSA-5623536) POMC(138-176) E79* [extracellular region] (R-HSA-5623539) POMC(138-176) R236G [extracellular region] (R-HSA-5603387) POMC(1-241) [secretory granule lumen] (R-HSA-378943) POMC(138-176) [secretory granule lumen] (R-HSA-378965)	0.556	3
UniProt:Q9H0C1 ZMY12			0.556	3
UniProt:O75934 BCAS2	1	BCAS2 [nucleoplasm] (R-HSA-5420902)	0.556	3
UniProt:Q96CS2 HAUS1	1	HAUS1 [cytosol] (R-HSA-8855199)	0.556	3
UniProt:Q9BXL8 CDCA4			0.556	3
UniProt:P61289 PSME3	1	PSME3 [cytosol] (R-HSA-68816)	0.556	3
UniProt:Q96NT3-2 GUCD1			0.556	3
UniProt:Q7Z3Y8 KRT27	1	KRT27 [cytosol] (R-HSA-6809587)	0.556	3
UniProt:P24844-2 MYL9			0.556	3
UniProt:Q5JR59-3 MTUS2			0.556	3
UniProt:Q96T49 PP16B			0.556	3
UniProt:O95571 ETHE1	1	ETHE1 [mitochondrial matrix] (R-HSA-1614628)	0.556	3
UniProt:Q96CG3 TIFA	2	TIFA [cytosol] (R-HSA-451582) p-T9-TIFA [cytosol] (R-HSA-9645512)	0.556	3
UniProt:P80188 LCN2	2	LCN2 [extracellular region] (R-HSA-5215934) LCN2 [specific granule lumen] (R-HSA-6799614)	0.556	3
UniProt:Q8IUH3-3 RBM45			0.556	3
UniProt:O43829 ZBT14			0.556	3
UniProt:Q5I0X7 TTC32			0.556	3
UniProt:Q8IZU0 FAM9B			0.556	3
UniProt:Q8NCU1 CC197			0.556	3
UniProt:Q5TD97 FHL5			0.556	3
UniProt:P43358 MAGA4			0.556	3
UniProt:P40855 PEX19	1	PEX19 [cytosol] (R-HSA-3009036)	0.556	3
UniProt:Q9UFW8 CGBP1			0.556	3
IntAct:EBI-22314709 CCSB ORF ID			0.556	3
UniProt:P35638 DDIT3	1	DDIT3 [nucleoplasm] (R-HSA-381110)	0.556	3
UniProt:Q8N0S2 SYCE1	1	SYCE1 [nucleoplasm] (R-HSA-912456)	0.556	3
UniProt:Q9H668 STN1	1	STN1 [nucleoplasm] (R-HSA-9668821)	0.556	3
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P21673 SAT1	1	SAT1 [cytosol] (R-HSA-351236)	0.556	3
UniProt:P02549 SPTA1	1	SPTA1 [cytosol] (R-HSA-391563)	0.556	3
UniProt:O15479 MAGB2			0.556	3
UniProt:Q674X7-2 KAZN			0.556	3
UniProt:A6NEM1 GG6L9			0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
UniProt:Q9BT25 HAUS8	1	HAUS8 [cytosol] (R-HSA-8855198)	0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:Q9BRT2 UQCC2	1	UQCC2 [mitochondrial inner membrane] (R-HSA-9865900)	0.556	3
UniProt:Q6ZN96 Q6ZN96			0.556	3
UniProt:A0PJX0 CIB4			0.556	3
UniProt:P32321 DCTD	1	DCTD [cytosol] (R-HSA-73592)	0.556	3
UniProt:Q8IUH3 RBM45			0.556	3
UniProt:Q8N4Y2-3 CRACR2B			0.556	3
UniProt:Q9H6J7-2 CSTPP1			0.556	3
UniProt:Q6RW13-2 AGTRAP			0.556	3
UniProt:Q96HR9-2 REEP6			0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:Q9P2A4 ABI3			0.556	3
UniProt:Q8TD10 MIPO1			0.556	3
UniProt:P43364-2 MAGEA11			0.556	3
UniProt:P63010-2 AP2B1			0.556	3
UniProt:Q9BX10 GTPBP2	2	GTPBP2 [extracellular region] (R-HSA-8863001) GTPBP2 [platelet alpha granule lumen] (R-HSA-8862960)	0.556	5
UniProt:Q96HR9 REEP6			0.556	3
UniProt:P63010 AP2B1	4	AP2B1 [endolysosome membrane] (R-HSA-6784827) AP2B1 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130489) AP2B1 [cytosol] (R-HSA-182166) AP2B1 [plasma membrane] (R-HSA-167690)	0.556	3
UniProt:Q9H3M7 TXNIP	2	TXNIP [cytosol] (R-HSA-1250246) TXNIP [nucleoplasm] (R-HSA-9617747)	0.527	2

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