GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+

Stable Identifier
R-HSA-3323079
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Glutathione reductase (GSR) in the mitochondrial matrix regenerates reduced glutathione from oxidized glutathione and NADPH (Berkholz et al. 2008).

Literature References
PubMed ID Title Journal Year
18638483 Catalytic cycle of human glutathione reductase near 1 A resolution

Berkholz, DS, Faber, HR, Savvides, SN, Karplus, PA

J. Mol. Biol. 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutathione-disulfide reductase activity of GSR dimer [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created