GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier
R-HSA-3341277
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

GPX2 (located in the gastrointestinal tract, also called GSHPx-GI, GPX-GI, and GI-GPx), like glutathione peroxidase 1 (GPX1, ubiquitous), reduces one molecule of hydrogen peroxide (H2O2) with two molecules of glutathione to yield one molecule of oxidized glutathione (glutathione disulfide, GSSG) and two molecules of water (Chu et al. 1998).

Literature References
PubMed ID Title Journal Year
8428933 Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI

Chu, FF, Doroshow, JH, Esworthy, RS

J Biol Chem 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutathione peroxidase activity of GPX2 tetramer [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed