Superoxide reduces cytochrome c

Stable Identifier
R-HSA-3341294
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Superoxide can reduce cytochrome c in the intermembrane space (Wegerich et al. 2013, and inferred from other mammals in Butler et al. 1975, Koppenol et al. 1976, Butler et al. 1982). Superoxide has been shown in rat and mouse mitochondria to be released into the intermembrane space by the complex III of the respiratory chain (Han et al. 2001, Muller et al. 2004).

Literature References
PubMed ID Title Journal Year
15317809 Complex III releases superoxide to both sides of the inner mitochondrial membrane

Muller, FL, Liu, Y, Van Remmen, H

J. Biol. Chem. 2004
23455484 Mechanistic insights into the superoxide-cytochrome c reaction by lysine surface scanning

Wegerich, F, Giachetti, A, Allegrozzi, M, Lisdat, F, Turano, P

J. Biol. Inorg. Chem. 2013
60 The reaction between the superoxide anion radical and cytochrome c

Butler, J, Jayson, GG, Swallow, AJ

Biochim. Biophys. Acta 1975
6286671 Kinetics and mechanism of the reduction of ferricytochrome c by the superoxide anion

Butler, J, Koppenol, WH, Margoliash, E

J. Biol. Chem. 1982
11139407 Mitochondrial respiratory chain-dependent generation of superoxide anion and its release into the intermembrane space

Han, D, Williams, E, Cadenas, E

Biochem. J. 2001
10982 The kinetics of the reduction of cytochrome c by the superoxide anion radical

Koppenol, WH, van Buuren, KJ, Butler, J, Braams, R

Biochim. Biophys. Acta 1976
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