Reactome | GPX8 [endoplasmic reticulum lumen]

GPX8 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-3341303

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Probable glutathione peroxidase 8, GPX8_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
21215271	Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation Nguyen, VD, Saaranen, MJ, Karala, AR, Lappi, AK, Wang, L, Raykhel, IB, Alanen, HI, Salo, KE, Wang, CC, Ruddock, LW	J. Mol. Biol.	2011

External Reference Information

External Reference

UniProt:Q8TED1 GPX8

Gene Names

GPX8, UNQ847/PRO1785

Chain

chain:1-209

Reference Genes

BioGPS Gene:493869 GPX8

COSMIC (genes):GPX8 GPX8

CTD Gene:493869 GPX8

dbSNP Gene:493869 GPX8

ENSEMBL:ENSG00000164294 GPX8

HGNC:33100 GPX8

KEGG Gene (Homo sapiens):493869 GPX8

Monarch:493869 GPX8

NCBI Gene:493869 GPX8

UCSC:Q8TED1 GPX8

Reference Transcript

Other Identifiers

0105900725

11729644_a_at

11729645_x_at

16984809

227628_at

228141_at

241120_s_at

2809833

2809834

2809835

2809838

2809839

2809841

2809842

2809843

2809844

2809845

2809846

2809847

2809848

2809849

493869

52123_at

8105348

A_23_P122052

A_23_P404259

A_24_P876522

GE88680

GO:0003674

GO:0004601

GO:0004602

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0006950

GO:0006979

GO:0008150

GO:0016020

GO:0016021

GO:0016491

GO:0034599

GO:0043226

GO:0055114

GO:0098869

Hs.170708.0.A1_3p_at

Hs.252280.2.S1_3p_at

Hs.289044.0.S1_3p_at

ILMN_1767665

ILMN_3242038

PH_hs_0015025

TC05000232.hg

Participant Of

hasMember

GPX7,8 [endoplasmic reticulum lumen]

Inferred To

gpx8 [endoplasmic reticulum lumen] (Danio rerio)

GPX8 [endoplasmic reticulum lumen] (Canis familiaris)

GPX8 [endoplasmic reticulum lumen] (Plasmodium falciparum)

GPX8 [endoplasmic reticulum lumen] (Sus scrofa)

Gpx8 [endoplasmic reticulum lumen] (Mus musculus)

Gpx8 [endoplasmic reticulum lumen] (Rattus norvegicus)

Cross References

RefSeq

NP_001293127.1, NP_001293126.1, NP_001008398.2, NP_001293130.1

OpenTargets

ENSG00000164294

HPA

ENSG00000164294-GPX8

GeneCards

Q8TED1

Ensembl

ENSP00000423822, ENSG00000164294, ENST00000503787

PRO

Q8TED1

PDB

3KIJ, 3CYN

HMDB Protein

HMDBP11754

Interactors (37)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95674 CDS2	1	CDS2 [mitochondrial inner membrane] (R-HSA-1498755)	0.556	3
UniProt:Q9BVK2 ALG8	5	ALG8 T47P [endoplasmic reticulum membrane] (R-HSA-4724334) ALG8 G275D [endoplasmic reticulum membrane] (R-HSA-4724304) ALG8 V133Sfs3 [endoplasmic reticulum membrane] (R-HSA-4724313) ALG8 T138Kfs19 [endoplasmic reticulum membrane] (R-HSA-4724312) ALG8 [endoplasmic reticulum membrane] (R-HSA-449640)	0.556	3
UniProt:O14653 GOSR2	4	GOSR2 [endoplasmic reticulum membrane] (R-HSA-5689451) GOSR2 [Golgi membrane] (R-HSA-6807755) GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-535472) GOSR2 [ER to Golgi transport vesicle membrane] (R-HSA-5689800)	0.556	3
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.556	3
UniProt:O60883 GPR37L1	1	GPR37L1 [plasma membrane] (R-HSA-5336178)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:Q9Y5Q5 CORIN	1	CORIN(802-1042) [plasma membrane] (R-HSA-5490311)	0.556	3
UniProt:O15155 BET1	3	BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743) BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142)	0.556	3
UniProt:Q96E93 KLRG1	1	KLRG1 [plasma membrane] (R-HSA-198006)	0.556	3
UniProt:O95406 CNIH1	3	CNIH1 [ER to Golgi transport vesicle membrane] (R-HSA-5689776) CNIH1 [endoplasmic reticulum membrane] (R-HSA-5689439) CNIH1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689778)	0.556	3
UniProt:Q9Y6X1 SERP1	2	SERP1 [cytosol] (R-HSA-5250574) SERP1 [endoplasmic reticulum membrane] (R-HSA-381045)	0.556	3
UniProt:Q8IY26 PLPP6	1	PLPP6 [plasma membrane] (R-HSA-8952144)	0.556	3
UniProt:P02656 APOC3	2	APOC3 [early endosome] (R-HSA-2429646) APOC3 [extracellular region] (R-HSA-174725)	0.556	3
UniProt:P11686 SFTPC	9	pro-SFTPC P30L [endoplasmic reticulum membrane] (R-HSA-5688365) pro-SFTPC P115L [endoplasmic reticulum membrane] (R-HSA-5688352) pro-SFTPC [endoplasmic reticulum membrane] (R-HSA-5683842) pro-SFTPC [multivesicular body lumen] (R-HSA-5685298) SFTPC [extracellular region] (R-HSA-5683685) SFTPC [clathrin-coated endocytic vesicle] (R-HSA-5686342) SFTPC [lamellar body] (R-HSA-5683717) SFTPC(24-58) [multivesicular body lumen] (R-HSA-5685899) SFTPC(59-197) [multivesicular body lumen] (R-HSA-5685871)	0.556	3
UniProt:P02787 TF	6	TF [secretory granule lumen] (R-HSA-350704) apoTF [clathrin-coated endocytic vesicle membrane] (R-HSA-8869140) p-TF [endoplasmic reticulum lumen] (R-HSA-8957001) TF [endoplasmic reticulum lumen] (R-HSA-8956763) apoTF [extracellular region] (R-HSA-350754) apoTF [endosome membrane] (R-HSA-917974)	0.556	3
UniProt:P78382 SLC35A1	2	SLC35A1 V93Cfs*17 [Golgi membrane] (R-HSA-5651957) SLC35A1 [Golgi membrane] (R-HSA-727812)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:P07204 THBD	1	THBD [plasma membrane] (R-HSA-141030)	0.556	3
UniProt:Q8N130 SLC34A3	6	SLC34A3 R468W [plasma membrane] (R-HSA-5651979) SLC34A3 P303Rfs40 [plasma membrane] (R-HSA-5651944) SLC34A3 C77Afs75 [plasma membrane] (R-HSA-5651981) SLC34A3 G196R [plasma membrane] (R-HSA-5651982) SLC34A3 G191R [plasma membrane] (R-HSA-5651955) SLC34A3 [plasma membrane] (R-HSA-427665)	0.556	3
UniProt:O75379 VAMP4	4	VAMP4 [trans-Golgi network membrane] (R-HSA-6811021) VAMP4 [transport vesicle] (R-HSA-6811023) VAMP4 [plasma membrane] (R-HSA-8864461) VAMP4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869133)	0.556	3
UniProt:Q9UPQ8 DOLK	6	DOLK M1I [endoplasmic reticulum membrane] (R-HSA-4755593) DOLK [endoplasmic reticulum membrane] (R-HSA-449274) DOLK H408D [endoplasmic reticulum membrane] (R-HSA-4755548) DOLK C99S [endoplasmic reticulum membrane] (R-HSA-4755602) DOLK W304C [endoplasmic reticulum membrane] (R-HSA-4755557) DOLK Y441S [endoplasmic reticulum membrane] (R-HSA-4755590)	0.556	3
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.556	3
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.556	3
UniProt:Q969S0 SLC35B4	1	SLC35B4 [Golgi membrane] (R-HSA-742365)	0.556	3
UniProt:Q8N0U8 VKORC1L1	1	VKORC1L1 [endoplasmic reticulum membrane] (R-HSA-2980944)	0.556	3
UniProt:Q14162 SCARF1	2	SCARF1 [endocytic vesicle membrane] (R-HSA-2239453) SCARF1 [plasma membrane] (R-HSA-2197636)	0.556	3
UniProt:P05090 APOD	1	APOD [extracellular region] (R-HSA-5216199)	0.556	3
UniProt:P24593 IGFBP5	5	p-IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956988) IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956738) IGFBP5 [extracellular region] (R-HSA-381414) IGFBP5(21-163) [extracellular region] (R-HSA-381415) IGFBP5(164-272) [extracellular region] (R-HSA-381478)	0.556	3
UniProt:O43916 CHST1	1	CHST1 [Golgi membrane] (R-HSA-1971540)	0.556	3
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.556	3
UniProt:Q7L5A8 FA2H	1	FA2H [endoplasmic reticulum membrane] (R-HSA-5693771)	0.556	3
UniProt:Q8WWT9 SLC13A3	1	SLC13A3 [plasma membrane] (R-HSA-433095)	0.556	3
UniProt:Q8NHU3 SGMS2	1	2xPalmC-SGMS2 [plasma membrane] (R-HSA-429775)	0.556	3
UniProt:Q15836 VAMP3	6	VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.556	3
UniProt:Q9NPL8 TIMMDC1	1	TIMMDC1 [mitochondrial inner membrane] (R-HSA-5689720)	0.556	3
UniProt:Q12982 BNIP2	1	BNIP2 [cytosol] (R-HSA-200792)	0.556	3
UniProt:Q16625 OCLN	4	OCLN(1-320) [plasma membrane] (R-HSA-351854) OCLN [cell junction] (R-HSA-2160944) OCLN(321-522) [plasma membrane] (R-HSA-351873) OCLN [plasma membrane] (R-HSA-351846)	0.556	3

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