PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O

Stable Identifier
R-HSA-3341343
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Peroxiredoxin 1 (PRDX1), PRDX2, and PRDX5 in the cytosol reduce hydrogen peroxide (H2O2) with thioredoxin yielding oxidized thioredoxin and water (Yamashita et al. 1999, Lee et al. 2007, Nagy et al. 2011).

Literature References
PubMed ID Title Journal Year
10514471 Characterization of human and murine PMP20 peroxisomal proteins that exhibit antioxidant activity in vitro

Yamashita, H, Avraham, S, Jiang, S, London, R, Van Veldhoven, PP, Subramani, S, Rogers, RA, Avraham, H

J. Biol. Chem. 1999
21385867 Model for the exceptional reactivity of peroxiredoxins 2 and 3 with hydrogen peroxide: a kinetic and computational study

Nagy, P, Karton, A, Betz, A, Peskin, AV, Pace, P, O'Reilly, RJ, Hampton, MB, Radom, L, Winterbourn, CC

J. Biol. Chem. 2011
17519234 Human peroxiredoxin 1 and 2 are not duplicate proteins: the unique presence of CYS83 in Prx1 underscores the structural and functional differences between Prx1 and Prx2

Lee, W, Choi, KS, Riddell, J, Ip, C, Ghosh, D, Park, JH, Park, YM

J. Biol. Chem. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thioredoxin peroxidase activity of PRDX1,2,5 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created