GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier
R-HSA-3341397
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Glutathione peroxidase 3 (GPX3) in plasma reduces hydrogen peroxide (H2O2) with glutathione to yield oxidized glutathione and water (Maddipati and Marnett 1987, Takahashi et al. 1987, Chung et al. 2009, Ottaviano et al. 2009). Glutathione is synthesized in the liver and exported into the plasma.

Literature References
PubMed ID Title Journal Year
18936159 Glutathione peroxidase 3 mediates the antioxidant effect of peroxisome proliferator-activated receptor gamma in human skeletal muscle cells

Chung, SS, Kim, M, Youn, BS, Lee, NS, Park, JW, Lee, IK, Lee, YS, Kim, JB, Cho, YM, Lee, HK, Park, KS

Mol. Cell. Biol. 2009
3619451 Purification and characterization of human plasma glutathione peroxidase: a selenoglycoprotein distinct from the known cellular enzyme

Takahashi, K, Avissar, N, Whitin, J, Cohen, H

Arch. Biochem. Biophys. 1987
19219623 Regulation of the extracellular antioxidant selenoprotein plasma glutathione peroxidase (GPx-3) in mammalian cells

Ottaviano, FG, Tang, SS, Handy, DE, Loscalzo, J

Mol. Cell. Biochem. 2009
3693360 Characterization of the major hydroperoxide-reducing activity of human plasma. Purification and properties of a selenium-dependent glutathione peroxidase

Maddipati, KR, Marnett, LJ

J. Biol. Chem. 1987
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutathione peroxidase activity of GPX3 tetramer [extracellular region]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created