PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O

Stable Identifier
R-HSA-3343700
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Peroxiredoxin 6 (PRDX6) forms a heterodimer with GSTP1 (Pi Glutathione transferase) and catalyzes the reduction of hydrogen peroxide (H2O2) by glutathione to yield oxidized glutathione and water (Ralat et al. 2006, Ralat et al. 2008, Zhou et al. 2013).

Literature References
PubMed ID Title Journal Year
23164639 Functional interaction of glutathione S-transferase pi and peroxiredoxin 6 in intact cells

Zhou, S, Lien, YC, Shuvaeva, T, DeBolt, K, Feinstein, SI, Fisher, AB

Int. J. Biochem. Cell Biol. 2013
18358825 Characterization of the complex of glutathione S-transferase pi and 1-cysteine peroxiredoxin

Ralat, LA, Misquitta, SA, Manevich, Y, Fisher, AB, Colman, RF

Arch. Biochem. Biophys. 2008
16401067 Direct evidence for the formation of a complex between 1-cysteine peroxiredoxin and glutathione S-transferase pi with activity changes in both enzymes

Ralat, LA, Manevich, Y, Fisher, AB, Colman, RF

Biochemistry 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutathione peroxidase activity of PRDX6:GSTP1 [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed