Reactome: A Curated Pathway Database

beta-catenin is replaced by repression complexes at the promoter

Stable Identifier
R-HSA-3361751
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Displacement of the APC:CTBP:beta-catenin:betaTrCP complex allows subsequent recruitment of TLE:HDAC1 to TCF/LEF, re-establishing a repression complex (Sierra et al, 2006)

Literature References
Participants
Participant Of
Orthologous Events