beta-catenin is replaced by repression complexes at the promoter

Stable Identifier
R-HSA-3361751
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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beta-catenin is replaced by repression complexes at the promoter
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Displacement of the APC:CTBP:beta-catenin:betaTrCP complex allows subsequent recruitment of TLE:HDAC1 to TCF/LEF, re-establishing a repression complex (Sierra et al, 2006)
Literature References
PubMed ID Title Journal Year
16510874 The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes

Yoshida, T, Jones, KA, Sierra, J, Joazeiro, CA

Genes Dev. 2006
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Orthologous Events
beta-catenin is replaced by repression complexes at the promoter (Bos taurus)
beta-catenin is replaced by repression complexes at the promoter (Caenorhabditis elegans)
beta-catenin is replaced by repression complexes at the promoter (Canis familiaris)
beta-catenin is replaced by repression complexes at the promoter (Drosophila melanogaster)
beta-catenin is replaced by repression complexes at the promoter (Gallus gallus)
beta-catenin is replaced by repression complexes at the promoter (Mus musculus)
beta-catenin is replaced by repression complexes at the promoter (Rattus norvegicus)
beta-catenin is replaced by repression complexes at the promoter (Sus scrofa)
Authored
Rothfels, K  (2013-05-30)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-15)
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2013-05-13)
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