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APC [nucleoplasm]
Stable Identifier
R-HSA-3361755
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Adenomatous polyposis coli protein, APC_HUMAN
Icon
Locations in the PathwayBrowser for interactor UniProt:Q15691 MAPRE1
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Deactivation of the beta-catenin transactivating complex (Homo sapiens)
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
APC [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25054 APC
Gene Names
APC, DP2.5
Chain
initiator methionine:, chain:2-2843
Reference Genes
BioGPS Gene:324 APC
COSMIC (genes):APC APC
CTD Gene:324 APC
dbSNP Gene:324 APC
ENSEMBL:ENSG00000134982 APC
ENSEMBL_homo_sapiens_GENE:ENSG00000134982.18 APC
HGNC:583 APC
KEGG Gene (Homo sapiens):324 APC
Monarch:324 APC
NCBI Gene:324 APC
OMIM:611731 APC
UCSC:P25054 APC
Reference Transcript
RefSeq:NM_001127511.2 APC
RefSeq:NM_001127510.2 APC
RefSeq:NM_000038.5 APC
Other Identifiers
11731561_a_at
11731562_s_at
11757692_s_at
16988021
1912_s_at
203525_PM_s_at
203525_s_at
203526_PM_s_at
203526_s_at
203527_PM_s_at
203527_s_at
216933_3p_x_at
216933_PM_x_at
216933_x_at
2824218
2824220
2824225
2824230
2824232
2824233
2824239
2824244
2824245
2824248
2824253
2824256
2824257
2824258
2824266
2824267
2824268
2824272
2824273
2824274
2824275
2824276
2824277
2824279
324
36182_at
8107330
A_14_P106747
A_14_P116796
A_14_P135872
A_23_P70213
A_33_P3408983
GE58061
GO:0000278
GO:0000281
GO:0000776
GO:0000910
GO:0001708
GO:0003170
GO:0003203
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005794
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005874
GO:0005881
GO:0005886
GO:0005912
GO:0005923
GO:0006974
GO:0007010
GO:0007018
GO:0007026
GO:0007059
GO:0007094
GO:0007155
GO:0007389
GO:0007399
GO:0008013
GO:0008017
GO:0008092
GO:0008285
GO:0008286
GO:0012501
GO:0016020
GO:0016043
GO:0016055
GO:0016328
GO:0016342
GO:0016477
GO:0019887
GO:0019901
GO:0023052
GO:0030027
GO:0030154
GO:0030163
GO:0030178
GO:0030335
GO:0030877
GO:0031274
GO:0031625
GO:0032587
GO:0032886
GO:0034330
GO:0036211
GO:0042995
GO:0043065
GO:0043161
GO:0043226
GO:0043229
GO:0045295
GO:0045595
GO:0045732
GO:0045736
GO:0048471
GO:0048856
GO:0048870
GO:0051010
GO:0051988
GO:0060632
GO:0065003
GO:0070161
GO:0070830
GO:0070840
GO:0071944
GO:0090090
GO:0098772
GO:0120162
GO:0140014
GO:1902807
GO:1904781
GO:1990909
GO:2000134
HMNXSV003016363
Hs.75081.0.S2_3p_a_at
Hs.75081.1.S1_3p_a_at
ILMN_1662668
M73548_at
M74088_s_at
PH_hs_0031313
TC05003398.hg
g182396_3p_a_at
g4557318_3p_a_at
Participates
as an input of
APC promotes disassembly of beta-catenin transactivation complex (Homo sapiens)
as a component of
APC:CTBP:CTNNB1:BTRC [nucleoplasm] (Homo sapiens)
TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm] (Homo sapiens)
Other forms of this molecule
APC R213* [cytosol]
APC C1410* [cytosol]
APC K1310* [cytosol]
APC R499* [cytosol]
APC R1450* [cytosol]
APC G1357* [cytosol]
APC L1488* [cytosol]
APC S1400* [cytosol]
APC S1346* [cytosol]
APC R405* [cytosol]
APC S1281* [cytosol]
APC E1573* [cytosol]
APC R805* [cytosol]
APC R1386* [cytosol]
APC S1327* [cytosol]
APC E1209* [cytosol]
APC Q1469* [cytosol]
APC R564* [cytosol]
APC E1536* [cytosol]
APC G1288* [cytosol]
APC G1312* [cytosol]
APC R283* [cytosol]
APC Q1367* [cytosol]
APC E1353* [cytosol]
APC R332* [cytosol]
APC K993* [cytosol]
APC R876* [cytosol]
APC R302* [cytosol]
APC E1309* [cytosol]
APC Y935* [cytosol]
APC E1286* [cytosol]
APC Q1378* [cytosol]
APC R554* [cytosol]
APC S1356* [cytosol]
APC R232* [cytosol]
APC E1379* [cytosol]
APC E984* [cytosol]
APC R1114* [cytosol]
APC S1282* [cytosol]
APC Q1328* [cytosol]
APC E1295* [cytosol]
APC E1151* [cytosol]
APC E1322* [cytosol]
APC E1345* [cytosol]
APC K1308* [cytosol]
APC S1344* [cytosol]
APC E1577* [cytosol]
APC Q1127* [cytosol]
APC E1464* [cytosol]
APC E1317* [cytosol]
APC G1309Dfs*4 [cytosol]
APC W1049* [cytosol]
APC Q1429* [cytosol]
APC L1564* [cytosol]
APC Q1294* [cytosol]
APC K1363* [cytosol]
APC E1408* [cytosol]
APC E1284* [cytosol]
APC E1374* [cytosol]
APC Q767* [cytosol]
APC E941* [cytosol]
APC Q1303* [cytosol]
APC S943* [cytosol]
APC E1306* [cytosol]
APC S895* [cytosol]
APC S1315* [cytosol]
APC G1412* [cytosol]
APC Y1376* [cytosol]
APC Q886* [cytosol]
APC S1392* [cytosol]
APC S1539* [cytosol]
APC E1451* [cytosol]
APC E1397* [cytosol]
APC Q1406* [cytosol]
APC E1544* [cytosol]
APC F1197* [cytosol]
APC Q1338* [cytosol]
APC S811* [cytosol]
APC I1417 fs*2 [cytosol]
APC E1554* [cytosol]
p-ub-APC [cytosol]
K63polyUb-APC [cytosol]
APC(1-777) [cytosol]
APC(778-2843) [cytosol]
APC [cytosol]
Inferred To
Apc [nucleoplasm]
(Drosophila melanogaster)
Apc [nucleoplasm]
(Mus musculus)
Apc [nucleoplasm]
(Rattus norvegicus)
Apc2 [nucleoplasm]
(Drosophila melanogaster)
apr-1 [nucleoplasm]
(Caenorhabditis elegans)
apc [nucleoplasm]
(Xenopus tropicalis)
APC [nucleoplasm]
(Bos taurus)
APC [nucleoplasm]
(Canis familiaris)
APC [nucleoplasm]
(Gallus gallus)
APC [nucleoplasm]
(Sus scrofa)
Homologues of APC [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001120982.1
,
NP_001120983.2
,
NP_000029.2
OpenTargets
ENSG00000134982
HPA
ENSG00000134982-APC
GeneCards
P25054
Ensembl
ENSP00000427089
,
ENSG00000134982
,
ENSP00000257430
,
ENST00000508376
,
ENST00000257430
PRO
P25054
Pharos - Targets
P25054
Orphanet
16443
PDB
4YJL
,
2RQU
,
3QHE
,
1EMU
,
7F7O
,
3RL7
,
3NMW
,
3AU3
,
8X2Q
,
5IZA
,
1M5I
,
3T7U
,
4G69
,
1JPP
,
7F6M
,
4YK6
,
5Z8H
,
5IZ6
,
1DEB
,
8GSJ
,
3NMZ
,
5IZ8
,
4YJE
,
1T08
,
1V18
,
5IZ9
,
7XTY
,
3RL8
,
1TH1
,
5B6G
,
3NMX
Interactors (35)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.962
22
UniProt:O15169 AXIN1
11
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
p-T481,S486,S493-AXIN1 [cytosol]
(R-HSA-206040)
AXIN1 [cytosol]
(R-HSA-195249)
0.845
17
UniProt:Q15691 MAPRE1
1
MAPRE1 [cytosol]
(R-HSA-376240)
0.825
6
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.816
6
UniProt:Q13363 CTBP1
3
monoSUMO1-K428-CTBP1 [nucleoplasm]
(R-HSA-3108200)
polySUMO2,3-K428-CTBP1 [nucleoplasm]
(R-HSA-3108226)
CTBP1 [nucleoplasm]
(R-HSA-212372)
0.802
6
UniProt:P49674 CSNK1E
2
CSNK1E [nucleoplasm]
(R-HSA-421306)
CSNK1E [cytosol]
(R-HSA-205877)
0.738
8
UniProt:Q5JTC6 AMER1
5
AMER1 [cytosol]
(R-HSA-1504189)
AMER1 R353* [cytosol]
(R-HSA-9663939)
AMER1 R358* [cytosol]
(R-HSA-4839640)
AMER1 S210* [cytosol]
(R-HSA-5251492)
AMER1 R497* [cytosol]
(R-HSA-9663943)
0.723
4
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.697
5
UniProt:Q9NSA3 CTNNBIP1
1
CTNNBIP1 [nucleoplasm]
(R-HSA-3772388)
0.669
4
UniProt:P60953 CDC42
3
CDC42 [endoplasmic reticulum membrane]
(R-HSA-5672086)
CDC42 [cytosol]
(R-HSA-442630)
CDC42 [plasma membrane]
(R-HSA-449545)
0.668
9
UniProt:Q96N96 SPATA13
1
SPATA13 [cytosol]
(R-HSA-9690931)
0.667
5
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.667
4
UniProt:Q9NR80-3 ARHGEF4
0.646
5
UniProt:P35221 CTNNA1
2
CTNNA1 [cytosol]
(R-HSA-191697)
CTNNA1 [plasma membrane]
(R-HSA-191735)
0.64
3
UniProt:P14923 JUP
6
JUP [cytosol]
(R-HSA-201598)
JUP [cornified envelope]
(R-HSA-8847739)
JUP [specific granule lumen]
(R-HSA-6799534)
JUP [extracellular region]
(R-HSA-6806309)
JUP [ficolin-1-rich granule lumen]
(R-HSA-6801028)
JUP [plasma membrane]
(R-HSA-437260)
0.64
3
UniProt:Q8N944 AMER3
0.631
8
UniProt:O14640 DVL1
4
pp-DVL1 [cytosol]
(R-HSA-3772396)
p-S-DVL1 [cytosol]
(R-HSA-201700)
DVL1 [cytosol]
(R-HSA-201687)
ub-DVL1 [cytosol]
(R-HSA-4641157)
0.623
6
UniProt:Q12959 DLG1
4
DLG1 [cytosol]
(R-HSA-416332)
DLG1 [endoplasmic reticulum membrane]
(R-HSA-9610593)
DLG1 [transport vesicle membrane]
(R-HSA-9610631)
DLG1 [plasma membrane]
(R-HSA-375977)
0.623
2
UniProt:Q02248 Ctnnb1
14
phospho-Ctnnb1 [cytosol]
(R-MMU-3134933)
phospho-Ctnnb1 [nucleoplasm]
(R-MMU-3134926)
Ctnnb1 [plasma membrane]
(R-MMU-9761458)
Ctnnb1 [plasma membrane]
(R-MMU-9038440)
Ctnnb1 [nucleoplasm]
(R-MMU-3451168)
Ctnnb1 [cytosol]
(R-MMU-448839)
Ctnnb1 [cytosol]
(R-MMU-202930)
Ctnnb1 [cytosol]
(R-MMU-202950)
Ctnnb1 [nucleoplasm]
(R-MMU-9735212)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942374)
beta-catenin [cytosol]
(R-MMU-206225)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942369)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942367)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942363)
0.623
8
UniProt:Q96N96-1 SPATA13
0.619
5
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.615
3
UniProt:O14936 CASK
1
CASK [cytosol]
(R-HSA-373631)
0.59
2
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.564
2
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.564
2
UniProt:Q14114 LRP8
2
p-Y-LRP8 [plasma membrane]
(R-HSA-432136)
LRP8 [plasma membrane]
(R-HSA-432113)
0.558
2
UniProt:Q86T90 K1328
0.547
2
UniProt:O14513 NCKP5
0.547
2
UniProt:Q04695 KRT17
1
KRT17 [cytosol]
(R-HSA-201583)
0.547
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.536
2
UniProt:Q16204 CCDC6
0.527
4
UniProt:Q9NUP9 LIN7C
2
LIN7C [plasma membrane]
(R-HSA-5216165)
LIN7C [transport vesicle membrane]
(R-HSA-9610411)
0.527
2
UniProt:Q9H9D4 ZN408
0.527
2
UniProt:Q9UI47 CTNA3
0.527
3
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.527
3
IntAct:EBI-6876712 CTNB1
0.499
6
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