Reactome | Ub-121-HIST1H2BO [nucleoplasm]

Ub-121-HIST1H2BO [nucleoplasm]

Stable Identifier

R-HSA-3364033

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone H2B.n K121ub

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by WNT (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
      - SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
        
        MYC gene: H2B K121ub nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H2BK121ub [nucleoplasm] (Homo sapiens)
        
        Histone H2B K121ub [nucleoplasm] (Homo sapiens)
        
        Ub-121-HIST1H2BO [nucleoplasm] (Homo sapiens)
        
        MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Homo sapiens)
        
        Nucleosome with H2BK121ub and H3K4me3 [nucleoplasm] (Homo sapiens)
        
        Histone H2B K121ub [nucleoplasm] (Homo sapiens)
        
        Ub-121-HIST1H2BO [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23527 H2BC17

Gene Names

H2BC17, H2BFH, H2BFN, HIST1H2BO

Chain

initiator methionine:1, chain:2-126

Reference Genes

BioGPS Gene:8348 H2BC17

CTD Gene:8348 H2BC17

dbSNP Gene:8348 H2BC17

ENSEMBL:ENSG00000274641 HIST1H2BO

HGNC:4758 H2BC17

KEGG Gene (Homo sapiens):8348 H2BC17

Monarch:8348 H2BC17

NCBI Gene:8348 H2BC17

OMIM:602808 H2BC17

UCSC:P23527 H2BC17

Reference Transcript

RefSeq:NM_003527.4 H2BC17

Other Identifiers

0004480280

11742176_s_at

17005880

214540_at

2900118

2900119

2900120

8117614

8348

ADDON002745.hg

A_23_P59069

GO:0000786

GO:0003674

GO:0003677

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006334

GO:0006464

GO:0008150

GO:0016567

GO:0022607

GO:0032991

GO:0043226

GO:0046982

GO:0051276

GO:0065003

Hs.151506.0.S1_3p_at

Hs.151506.0.S1_3p_x_at

ILMN_1739076

PH_hs_0036083

TC06000270.hg

Participant Of

hasCandidate

Histone H2B K121ub [nucleoplasm]

Other forms of this molecule

HIST1H2BO [extracellular region]

Ub-HIST1H2BO [nucleoplasm]

AcK-HIST1H2BO [nucleoplasm]

AcK13-HIST1H2BO [nucleoplasm]

AcK21-HIST1H2BO [nucleoplasm]

AcK16-HIST1H2BO [nucleoplasm]

AcK6-HIST1H2BO [nucleoplasm]

HIST1H2BO [nucleoplasm]

Inferred To

his-34 [nucleoplasm] (Caenorhabditis elegans)

H2Bv3 [nucleoplasm] (Dictyostelium discoideum)

Homologues of Ub-121-HIST1H2BK [nucleoplasm] (Saccharomyces cerevisiae)

htb1 [nucleoplasm] (Schizosaccharomyces pombe)

Homologues of Ub-121-HIST1H2BB [nucleoplasm] (Caenorhabditis elegans)

hist2h2l [nucleoplasm] (Danio rerio)

HTB1 [nucleoplasm] (Saccharomyces cerevisiae)

hist1h2bj [nucleoplasm] (Xenopus tropicalis)

his-54 [nucleoplasm] (Caenorhabditis elegans)

Ub-121-HIST1H2BK [nucleoplasm] (Plasmodium falciparum)

HTB2 [nucleoplasm] (Saccharomyces cerevisiae)

Ub-121-HIST1H2BO [nucleoplasm] (Canis familiaris)

Ub-121-HIST1H2BO [nucleoplasm] (Sus scrofa)

Modified Residues

Name

ubiquitinylated lysine at 121

Coordinate

121

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_003518.2

OpenTargets

ENSG00000274641

HPA

ENSG00000274641-HIST1H2BO

GeneCards

P23527

Ensembl

ENSG00000274641, ENSP00000477527, ENST00000616182

PRO

P23527

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8NAV1 PRPF38A	1	PRPF38A [nucleoplasm] (R-HSA-8867897)	0.508	2