The ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomeric to trimeric state.

• Regulation of HSF1-mediated heat shock response (Arabidopsis thaliana)
• Regulation of HSF1-mediated heat shock response (Bos taurus)
• Regulation of HSF1-mediated heat shock response (Caenorhabditis elegans)
• Regulation of HSF1-mediated heat shock response (Canis familiaris)
• Regulation of HSF1-mediated heat shock response (Danio rerio)
• Regulation of HSF1-mediated heat shock response (Dictyostelium discoideum)
• Regulation of HSF1-mediated heat shock response (Drosophila melanogaster)
• Regulation of HSF1-mediated heat shock response (Gallus gallus)
• Regulation of HSF1-mediated heat shock response (Mus musculus)
• Regulation of HSF1-mediated heat shock response (Oryza sativa)
• Regulation of HSF1-mediated heat shock response (Plasmodium falciparum)
• Regulation of HSF1-mediated heat shock response (Rattus norvegicus)
• Regulation of HSF1-mediated heat shock response (Saccharomyces cerevisiae)
• Regulation of HSF1-mediated heat shock response (Schizosaccharomyces pombe)
• Regulation of HSF1-mediated heat shock response (Sus scrofa)
• Regulation of HSF1-mediated heat shock response (Taeniopygia guttata)
• Regulation of HSF1-mediated heat shock response (Xenopus tropicalis)