SIRT1 binds to HSF1

Stable Identifier
R-HSA-3371518
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Surtuin 1 (SIRT1) has been shown to bind HSF1 and to function as a regulator of HSF1 DNA binding activity by controling the acetylation status of HSF1 (Westerheide SD et al 2009). SIRT1 mediates NAD(+)-dependent protein deacetylation.

Literature References
PubMed ID Title Journal Year
19229036 Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1

Westerheide, SD, Anckar, J, Stevens, SM, Sistonen, L, Morimoto, RI

Science 2009
23349863 The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response

Raynes, R, Pombier, KM, Nguyen, K, Brunquell, J, Mendez, JE, Westerheide, SD

PLoS ONE 2013
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Orthologous Events
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