DBC1 is phosphorylated by ATM/ART

Stable Identifier
R-HSA-3371567
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The stress-induced DBC1-SIRT1 interaction required the ATM/ATR-dependent phosphorylation of DBC1 at Thr454 (Yuan J et al. 2012; Zannini L et al. 2012).

Literature References
PubMed ID Title Journal Year
22735644 DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage

Zannini, L, Buscemi, G, Kim, JE, Fontanella, E, Delia, D

J Mol Cell Biol 2012
22465953 Regulation of SIRT1 activity by genotoxic stress

Yuan, J, Luo, K, Liu, T, Lou, Z

Genes Dev. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of ATM/ATR kinase [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created