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Dissociation of cytosolic HSF1:HSP90 complex
Stable Identifier
R-HSA-3371586
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to heat stress (Homo sapiens)
HSF1 activation (Homo sapiens)
Dissociation of cytosolic HSF1:HSP90 complex (Homo sapiens)
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In the absence of stress HSF1 is predominantly monomeric and is thought to be repressed in its inactive monomeric state by the following mechanisms:
interaction with chaperone proteins such as HSP90 (Zou J et al.1998; Guo Y et al. 2001)
intramolecular coiled-coil interactions between a hydrophobic leucine zipper domain in the carboxyl-terminus of the protein and three amino-terminal leucine zippers, which are required for homotrimerization and transcriptional activation (Rabindran SK et al. 1993; Zuo J et al. 1995)
post-translation modifications that include protein acetylation, sumoylation and phosphorylation may also contribute to HSF1 repression (Knauf U et al. 1996; Hietakangas V et al. 2003; Batista-Nascimento L et al. 2011)
The accumulation of misfolded proteins upon proteotoxic stresses leads to the release of HSF1 from the HSP90-containing multichaperone complex and results in HSF1 self-association to form homotrimers (Baler R et al. 1993). There is also evidence showing that HDAC6 senses the accumulation of misfolded, ubiquitinated protein aggregates in cells and induces dissociation of a repressive HDAC6:HSF1:HSP90 complex and subsequent HSF1 activation (Boyault C et al. 2007).
Literature References
PubMed ID
Title
Journal
Year
9727490
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1
Voellmy, R
,
Smith, DF
,
Guettouche, T
,
Guo, Y
,
Zou, J
Cell
1998
Participants
Input
HSF1:HSP90:PTGES3 [cytosol]
(Homo sapiens)
Output
HSF1 [cytosol]
(Homo sapiens)
HSP90:HSP90 [cytosol]
(Homo sapiens)
x 2
PTGES3 [cytosol]
(Homo sapiens)
Participates
as an event of
HSF1 activation (Homo sapiens)
Orthologous Events
Dissociation of cytosolic HSF1:HSP90 complex (Bos taurus)
Dissociation of cytosolic HSF1:HSP90 complex (Caenorhabditis elegans)
Dissociation of cytosolic HSF1:HSP90 complex (Dictyostelium discoideum)
Dissociation of cytosolic HSF1:HSP90 complex (Drosophila melanogaster)
Dissociation of cytosolic HSF1:HSP90 complex (Gallus gallus)
Dissociation of cytosolic HSF1:HSP90 complex (Mus musculus)
Dissociation of cytosolic HSF1:HSP90 complex (Rattus norvegicus)
Dissociation of cytosolic HSF1:HSP90 complex (Saccharomyces cerevisiae)
Dissociation of cytosolic HSF1:HSP90 complex (Schizosaccharomyces pombe)
Dissociation of cytosolic HSF1:HSP90 complex (Sus scrofa)
Authored
Shamovsky, V (2013-10-29)
Reviewed
Pani, B (2014-02-17)
Created
Shamovsky, V (2013-05-13)
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