Reactome | p-Y206,Y519-TEC [cytosol]

p-Y206,Y519-TEC [cytosol]

Stable Identifier

R-HSA-3448741

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fc epsilon receptor (FCERI) signaling (Homo sapiens)
    - FCERI mediated Ca+2 mobilization (Homo sapiens)
      - Autophosphorylation of BTK/ITK (Homo sapiens)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
        
        p-2Y-TEC kinases [cytosol] (Homo sapiens)
        
        p-Y206,Y519-TEC [cytosol] (Homo sapiens)
      - Phosphorylation of PLC-gamma (Homo sapiens)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
        
        p-2Y-TEC kinases [cytosol] (Homo sapiens)
        
        p-Y206,Y519-TEC [cytosol] (Homo sapiens)
        
        p-SYK/p-BTK [plasma membrane] (Homo sapiens)
        
        p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
        
        p-2Y-TEC kinases [cytosol] (Homo sapiens)
        
        p-Y206,Y519-TEC [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P42680 TEC

Gene Names

TEC, PSCTK4

Chain

chain:1-631

Reference Genes

BioGPS Gene:7006 TEC

COSMIC (genes):TEC TEC

CTD Gene:7006 TEC

dbSNP Gene:7006 TEC

ENSEMBL:ENSG00000135605 TEC

ENSEMBL_homo_sapiens_GENE:ENSG00000135605.13 TEC

HGNC:11719 TEC

KEGG Gene (Homo sapiens):7006 TEC

Monarch:7006 TEC

NCBI Gene:7006 TEC

OMIM:600583 TEC

UCSC:P42680 TEC

Reference Transcript

RefSeq:NM_003215.2 TEC

Other Identifiers

11733548_at

11733549_at

16975777

206301_PM_at

206301_at

2768395

2768397

2768398

2768400

2768402

2768405

2768409

2768411

2768412

2768413

2768416

2768420

2768422

2768424

2768425

2768426

2768427

2768428

2768440

2768441

2768445

3393781

37056_at

7006

8100231

A_23_P213114

A_24_P37712

GE81247

GO:0000166

GO:0002250

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005515

GO:0005524

GO:0005543

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0006468

GO:0007229

GO:0008289

GO:0010543

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0035556

GO:0036211

GO:0042060

GO:0042246

GO:0043226

GO:0043621

GO:0046872

GO:0048856

GO:0050852

GO:0050853

GO:0140096

HMNXSV003019418

ILMN_1666969

PH_hs_0023399

TC04001176.hg

U34380_rna1_s_at

g4507428_3p_at

Participates

as a member of

p-2Y-TEC kinases [cytosol] (Homo sapiens)

Other forms of this molecule

TEC [cytosol]

p-Y519-TEC [cytosol]

Inferred To

phospho-TEC [cytosol] (Gallus gallus)

phospho-p-Y206,Y519-TEC [cytosol] (Bos taurus)

phospho-p-Y206,Y519-TEC [cytosol] (Canis familiaris)

phospho-p-Y206,Y519-TEC [cytosol] (Drosophila melanogaster)

phospho-p-Y206,Y519-TEC [cytosol] (Mus musculus)

phospho-p-Y206,Y519-TEC [cytosol] (Rattus norvegicus)

phospho-p-Y206,Y519-TEC [cytosol] (Sus scrofa)

phospho-p-Y206,Y519-TEC [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 519

Coordinate

519

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 206

Coordinate

206

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_003206.2

ZINC - World Drugs

TEC_HUMAN

Guide to Pharmacology - Targets

2238

OpenTargets

ENSG00000135605

ZINC - FDA approved

TEC_HUMAN

ZINC - Substances

TEC_HUMAN

ZINC - Biogenic

TEC_HUMAN

ZINC target

P42680

PRO

P42680

PDB

2LUL

ZINC - Investigational

TEC_HUMAN

HPA

ENSG00000135605-TEC

GeneCards

P42680

Ensembl

ENSP00000370912, ENSG00000135605, ENST00000381501

Pharos - Targets

P42680

ZINC - Predictions - Purchasable

TEC_HUMAN

HMDB Protein

HMDBP01370

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P78325 ADAM8	4	ADAM8 [ficolin-1-rich granule membrane] (R-HSA-6801017) ADAM8 [specific granule membrane] (R-HSA-6799563) ADAM8 [plasma membrane] (R-HSA-708331) ADAM8 [tertiary granule membrane] (R-HSA-6800884)	0.558	2