Beta-catenin recruits TRRAP/KAT5 HAT components

Stable Identifier
R-HSA-3451153
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Pulldown experiments in colorectal cancer cells show an interaction between the C-terminal region of beta-catenin (ARM domains 11 and 12 through the C terminal) with a number of TRRAP-KAT5 HAT complex members including TRRAP, TIP49, p400 and KAT5 (TIP60), among others (Sierra et al, 2006; Bauer et al, 1998; Bauer et al, 2000; Feng et al, 2003). KAT5 and TIP49 have been shown to directly regulate WNT target genes in vivo and are associated with increased H4 acetylation (Bauer et al, 2000; Feng et al, 2003; Kim et al, 2005).

Literature References
PubMed ID Title Journal Year
11080158 Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity

Bauer, A, Chauvet, S, Huber, O, Usseglio, F, Rothbächer, U, Aragnol, D, Kemler, R, Pradel, J

EMBO J. 2000
14695187 TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling

Feng, Y, Lee, N, Fearon, ER

Cancer Res. 2003
16510874 The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes

Sierra, J, Yoshida, T, Joazeiro, CA, Jones, KA

Genes Dev. 2006
15829968 Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes

Kim, JH, Kim, B, Cai, L, Choi, HJ, Ohgi, KA, Tran, C, Chen, C, Chung, CH, Huber, O, Rose, DW, Sawyers, CL, Rosenfeld, MG, Baek, SH

Nature 2005
9843967 Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein

Bauer, A, Huber, O, Kemler, R

Proc. Natl. Acad. Sci. U.S.A. 1998
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