Reactome | Beta-catenin recruits TRRAP/KAT5 HAT components

Beta-catenin recruits TRRAP/KAT5 HAT components

Stable Identifier

R-HSA-3451153

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

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Beta-catenin recruits TRRAP/KAT5 HAT components

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Pulldown experiments in colorectal cancer cells show an interaction between the C-terminal region of beta-catenin (ARM domains 11 and 12 through the C terminal) with a number of TRRAP-KAT5 HAT complex members including TRRAP, TIP49, p400 and KAT5 (TIP60), among others (Sierra et al, 2006; Bauer et al, 1998; Bauer et al, 2000; Feng et al, 2003). KAT5 and TIP49 have been shown to directly regulate WNT target genes in vivo and are associated with increased H4 acetylation (Bauer et al, 2000; Feng et al, 2003; Kim et al, 2005).

Literature References

PubMed ID	Title	Journal	Year
11080158	Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity Bauer, A, Chauvet, S, Huber, O, Usseglio, F, Rothbächer, U, Aragnol, D, Kemler, R, Pradel, J	EMBO J.	2000
14695187	TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling Feng, Y, Lee, N, Fearon, ER	Cancer Res.	2003
16510874	The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes Sierra, J, Yoshida, T, Joazeiro, CA, Jones, KA	Genes Dev.	2006
15829968	Transcriptional regulation of a metastasis suppressor gene by Tip60 and beta-catenin complexes Kim, JH, Kim, B, Cai, L, Choi, HJ, Ohgi, KA, Tran, C, Chen, C, Chung, CH, Huber, O, Rose, DW, Sawyers, CL, Rosenfeld, MG, Baek, SH	Nature	2005
9843967	Pontin52, an interaction partner of beta-catenin, binds to the TATA box binding protein Bauer, A, Huber, O, Kemler, R	Proc. Natl. Acad. Sci. U.S.A.	1998