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polySUMO2,3-K509-MTA1 [nucleoplasm]
Stable Identifier
R-HSA-3465537
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
polySUMO2,3 N-glycyl-lys509 MTA1, Metastasis-associated protein MTA1
Locations in the PathwayBrowser for interactor UniProt:O14519 CDKA1
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription factors (Homo sapiens)
PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Homo sapiens)
polySUMO2,3-K509-MTA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13330 MTA1
Gene Names
MTA1
Chain
chain:1-715
Reference Genes
BioGPS Gene:9112 MTA1
COSMIC (genes):MTA1 MTA1
CTD Gene:9112 MTA1
dbSNP Gene:9112 MTA1
ENSEMBL:ENSG00000182979 MTA1
HGNC:7410 MTA1
KEGG:hsa:9112 MTA1
Monarch:9112 MTA1
NCBI Gene:9112 MTA1
OMIM:603526 MTA1
UCSC:Q13330 MTA1
Reference Transcript
RefSeq:NM_004689.3 MTA1
RefSeq:NM_001203258.1 MTA1
Other Identifiers
11727668_a_at
11746358_a_at
11757774_x_at
1642_at
1643_g_at
16789681
202247_PM_s_at
202247_s_at
211783_PM_s_at
211783_s_at
3554746
3554747
3554748
3554749
3554759
3554760
3554767
3554768
3554774
3554775
3554776
3554778
3554779
3554780
3554781
3554784
3554785
3554787
3554788
3554789
3554790
3554791
3554792
3554793
3554794
3554795
3554796
3554797
3554798
3554799
3554800
3554801
3554802
3554803
3554804
3554805
3554806
3554807
3554808
3554810
3554811
3554812
3554813
3554815
3554816
3554817
38633_at
7977373
9112
A_14_P105611
A_14_P119329
A_14_P123297
A_14_P123899
A_23_P9513
A_24_P241370
A_24_P241373
A_33_P3359306
GE59104
GO:0000122
GO:0000978
GO:0003677
GO:0003682
GO:0003713
GO:0003714
GO:0005515
GO:0005634
GO:0005635
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005874
GO:0006281
GO:0006302
GO:0006325
GO:0006338
GO:0006355
GO:0007165
GO:0010212
GO:0016581
GO:0030163
GO:0032922
GO:0042659
GO:0042826
GO:0043153
GO:0043161
GO:0043226
GO:0043231
GO:0043565
GO:0045475
GO:0045814
GO:0045892
GO:0045893
GO:0046872
GO:0048511
GO:0060090
GO:0061629
GO:0140110
GO:1902499
GO:2000736
HMNXSV003027770
Hs.101448.0.S1_3p_s_at
ILMN_1671911
PH_hs_0005642
TC14000836.hg
U35113_at
g13544097_3p_s_at
Participates
as an output of
PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Homo sapiens)
Other forms of this molecule
MTA1 [nucleoplasm]
Inferred To
MTA1-like [nucleoplasm]
(Drosophila melanogaster)
polySUMO2,3-K509-MTA1 [nucleoplasm]
(Gallus gallus)
MTA1 [nucleoplasm]
(Bos taurus)
MTA1 [nucleoplasm]
(Sus scrofa)
mybS [nucleoplasm]
(Dictyostelium discoideum)
Mta1 [nucleoplasm]
(Mus musculus)
Mta1 [nucleoplasm]
(Rattus norvegicus)
mta1 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 509
Coordinate
509
Modification
polySUMO2,3 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_001190187.1
,
NP_004680.2
OpenTargets
ENSG00000182979
ENSEMBL
ENST00000331320
,
ENST00000405646
,
ENST00000438610
,
ENSP00000333633
,
ENSP00000393438
,
ENSP00000384180
HPA
ENSG00000182979-MTA1
PRO
Q13330
Pharos - Targets
Q13330
GlyGen
Q13330
PDB
4PBZ
,
7AO9
,
6ZRC
,
4PC0
,
7AOA
,
4PBY
,
5FXY
,
4BKX
,
5ICN
,
7AO8
,
6G16
,
6ZRD
Interactors (36)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.929
16
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.904
14
UniProt:Q92769 HDAC2
2
HDAC2 [nucleoplasm]
(R-HSA-205135)
monoSUMO1-K462-HDAC2 [nucleoplasm]
(R-HSA-4615958)
0.886
7
UniProt:Q16576 RBBP7
1
RBBP7 [nucleoplasm]
(R-HSA-212227)
0.725
6
UniProt:Q13422 IKZF1
0.666
5
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.666
4
UniProt:O00629 KPNA4
2
KPNA4 [cytosol]
(R-HSA-1176066)
KPNA4 [nucleoplasm]
(R-HSA-1176058)
0.666
4
UniProt:O14519 CDKA1
0.643
4
UniProt:O60315 ZEB2
1
ZEB2 [nucleoplasm]
(R-HSA-3108222)
0.612
12
UniProt:O95983 MBD3
1
MBD3 [nucleoplasm]
(R-HSA-4657010)
0.597
3
UniProt:P05412 JUN
4
JUN [nucleoplasm]
(R-HSA-450250)
p-S63,S73-JUN [nucleoplasm]
(R-HSA-450237)
JUN [cytosol]
(R-HSA-168194)
p-S63,S73-JUN [cytosol]
(R-HSA-8868682)
0.59
4
UniProt:Q96KQ7 EHMT2
1
EHMT2 [nucleoplasm]
(R-HSA-212151)
0.577
9
UniProt:Q16665 HIF1A
7
HIF1A [nucleoplasm]
(R-HSA-1234135)
HIF1A [cytosol]
(R-HSA-1234102)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
HN-HIF1A [cytosol]
(R-HSA-1234110)
0.556
6
UniProt:P0DPK4 NOTCH2NLC
1
NOTCH2NLC [extracellular region]
(R-HSA-9908932)
0.556
3
UniProt:Q5VWX1 KHDRBS2
2
KHDRBS2 [nucleoplasm]
(R-HSA-8849028)
p-Y-KHDRBS2 [nucleoplasm]
(R-HSA-8849031)
0.556
3
UniProt:P21673 SAT1
1
SAT1 [cytosol]
(R-HSA-351236)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q15323 KRT31
1
KRT31 [cytosol]
(R-HSA-6809616)
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:O00505 KPNA3
2
KPNA3 [nucleoplasm]
(R-HSA-1176061)
KPNA3 [cytosol]
(R-HSA-1176070)
0.556
3
UniProt:Q99961 SH3GL1
1
SH3GL1 [cytosol]
(R-HSA-8867732)
0.556
3
UniProt:Q7Z3S9 NOTCH2NLA
3
NOTCH2NLA [extracellular region]
(R-HSA-9908935)
NOTCH2NLA(1-?) [extracellular region]
(R-HSA-9911493)
NOTCH2NLA(?-236) [extracellular region]
(R-HSA-9911490)
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:Q58EX7 PLEKHG4
1
PLEKHG4 [cytosol]
(R-HSA-9679579)
0.556
3
UniProt:Q6FGM0 Q6FGM0
0.556
3
UniProt:P43364-2 MAGEA11
0.556
3
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.527
4
UniProt:Q14839 CHD4
1
CHD4 [nucleoplasm]
(R-HSA-3702078)
0.527
3
UniProt:Q8WXI9 GATAD2B
1
GATAD2B [nucleoplasm]
(R-HSA-3702079)
0.527
4
UniProt:Q86YP4 GATAD2A
1
GATAD2A [nucleoplasm]
(R-HSA-3702077)
0.527
3
UniProt:P19784 CSNK2A2
2
CSNK2A2 [cytosol]
(R-HSA-201721)
CSNK2A2 [nucleoplasm]
(R-HSA-6805065)
0.527
2
UniProt:Q9NSY1 BMP2K
0.488
2
UniProt:P68431 HIST1H3G
20
2xAcK-HIST1H3A [nucleoplasm]
(R-HSA-427507)
Me1K5-H3C1 [nucleoplasm]
(R-HSA-9677683)
Ack-Me3K5-HIST1H3A [nucleoplasm]
(R-HSA-4551293)
AcK-Me3K10-HIST1H3A [nucleoplasm]
(R-HSA-4551291)
AcK-Me3K28-HIST1H3A [nucleoplasm]
(R-HSA-4551292)
Me2aR27-HIST1H3A [nucleoplasm]
(R-HSA-5229052)
Me2aR18-HIST1H3A [nucleoplasm]
(R-HSA-5229062)
Me2sR9-HIST1H3A [nucleoplasm]
(R-HSA-5211328)
Me2sR3-HIST1H3A [nucleoplasm]
(R-HSA-5218935)
AcK9,14-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8870893)
AcK14,18,79-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871271)
AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871306)
AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871294)
AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8865596)
AcK14,18-p-S10-HIST1H3A [nucleoplasm]
(R-HSA-8871295)
AcK14,18,79-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871288)
AcK14,18-p-T11-HIST1H3A [nucleoplasm]
(R-HSA-8871299)
AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm]
(R-HSA-8871286)
Me2K28-HIST1H3A [nucleoplasm]
(R-HSA-4754193)
MeK37-HIST1H3A [nucleoplasm]
(R-HSA-4722135)
0.483
2
UniProt:Q9BRD0 BUD13
1
BUD13 [nucleoplasm]
(R-HSA-9769522)
0.483
2
UniProt:A2A935 Prdm16
2
Prdm16 [nucleoplasm]
(R-MMU-9854760)
Prdm16 [cytosol]
(R-MMU-5634812)
0.462
2
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