PIAS1,3,4 SUMOylate MTA1 with SUMO2,3

Stable Identifier
R-HSA-3465545
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 at lysine-509 (Cong et al. 2011). SUMOylation increases the repressor activity of MTA1 at the PS2 promoter (Cong et al. 2011).

Literature References
PubMed ID Title Journal Year
21965678 SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function

Cong, L, Pakala, SB, Ohshiro, K, Li, DQ, Kumar, R

J. Biol. Chem. 2011
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
SUMO transferase activity of PIAS1,3,4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created